WNT3 Protein, wingless-related MMTV integration site 3


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Official Full Name wingless-related MMTV integration site 3
Background Defects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA). Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects.
Synonyms WNT3; wingless-related MMTV integration site 3; Int-4; Wnt-3; proto-oncogene Wnt-3; proto-oncogene Int-4; proto-oncogene protein Wnt-3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • DDK
    • GST
    • His
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WNT3-3739H Recombinant Human WNT3 Protein, DDK-tagged CHO DDK
    Human WNT3-205H Recombinant Human WNT3, StrepII-tagged Human Cell Strep II
    Human WNT3-296HCL Recombinant Human WNT3 293 Cell Lysate HEK293 N/A
    Human WNT3-3738H Recombinant Human WNT3, His-tagged E.coli His
    Human WNT3-5161H Recombinant Human WNT3, GST-tagged Wheat Germ GST
    Mouse WNT3-5160M Recombinant Mouse WNT3 N/A
    Chicken WNT3-3658C Recombinant Chicken WNT3 Mammalian Cell His
    Zebrafish WNT3-6430Z Recombinant Zebrafish WNT3 Mammalian Cell His

    WNT3 involved in several pathways and played different roles in them. We selected most pathways WNT3 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway TCF7; WNT2B; LRP5; SOST; CAMK2D; RAC3; CACYBP; NLK2; PRKCB; PLCB4
    Hedgehog signaling pathway GAS1; PRKACAA; IHHB; Shh; GLI2B; PRKACAB; SMO; WNT9A; ZIC2A; IHH
    Hippo signaling pathway WNT4; PPP2R2D; WNT1; TCF7; AXIN2; LEF1; WWC1; BMPR1B; WNT8B; GDF7
    Signaling pathways regulating pluripotency of stem cells PIK3CG; WNT7B; SKIL; ZFHX3; LIF; MAPK11; WNT9A; FZD7; PAX6; WNT16
    HTLV-I infection TLN1; HLA-DOB; PIK3CG; NFATC3; FZD7; PIK3R5; DLG1; PTTG1; SPI1; HLA-E
    Pathways in cancer WNT5A; MSH2; AKT1; LAMB1; CTNNA3; RET; TPR; MAPK9; BAD; FGF1
    Proteoglycans in cancer FZD3; PRKCG; WNT4; CAMK2A; Fzd4; ITGB1; MMP2; MAP2K1; PLCG1; VTN
    MicroRNAs in cancer PLCG2; TGFB2; ST14; TNC; CCNG1; MMP9; DNMT3B; MDM4; Abcb1b; NOTCH2
    Basal cell carcinoma GLI2; TCF7; WNT16; DVL3; BMP4; WNT6; HHIP; SUFU; FZD2; APC

    WNT3 has several biochemical functions, for example, frizzled binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT3 itself. We selected most functions WNT3 had, and list some proteins which have the same functions with WNT3. You can find most of the proteins on our site.

    Function Related Protein
    frizzled binding NDP; WNT7AA; WNT5A; WNT16; WNT5B; WNT3A; WNT9A; ZNRF3; WNT4A; WNT11
    protein binding ABI3; Fzd4; PPIE; HAPLN2; ARMC7; PPAP2B; MAGEE1; SHOC2; LHX9; KRTAP10-11
    protein domain specific binding MED12; YWHABA; IST1; CNTROB; YWHAE2; PHRF1; GABRR1; RARA; TWIST2; WNT3A
    receptor agonist activity GAS6; VEGFA; WNT4; SFRP2; WNT7A; WNT3; WNT2; NODAL; WNT8A; WNT10B

    WNT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT3.


    Lighthouse, JK; Zhang, L; et al. MESD Is Essential for Apical Localization of Megalin/LRP2 in the Visceral Endoderm. DEVELOPMENTAL DYNAMICS 240:577-588(2011).
    Ettenberg, SA; Charlat, O; et al. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:15473-15478(2010).


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