wnt4
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  • Official Full Name
  • wingless-related MMTV integration site 4
  • Background
  • The evolutionarily conserved WNT (Wingless-type MMTV integration site family) signaling pathway has diverse roles in governing cell fate, proliferation, migration, polarity and death. WNT signaling controls development and is important for embryogenesis a
  • Synonyms
  • WNT4; wingless-related MMTV integration site 4; protein Wnt-4; signal molecule; Wnt-4; MGC123964; SERKAL
Cat.#:WNT4-516HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Wingless-Type MMTV Integration Site Family, Member 4
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Cat.#:WNT4-1891HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT4 protein, His-tagged
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Cat.#:WNT4-3740HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT4, GST-tagged
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Cat.#:WNT4-413HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT4 Protein, GST/His-tagged
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Cat.#:WNT4-18572MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WNT4 Protein
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Cat.#:Wnt4-622MTag:
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Wnt4
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Cat.#:WNT4-6599RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat WNT4 Protein
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Cat.#:WNT4-6347CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken WNT4
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Cat.#:WNT4-294HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WNT4 293 Cell Lysate
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Involved Pathway

WNT4 involved in several pathways and played different roles in them. We selected most pathways WNT4 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
CAMK2G1; AXIN2; VANGL1; WNT4; FZD1; BAMBIA; CCND1; RAC1B; WNT9B; PRKACB
Hedgehog signaling pathway
WNT7B; WNT4; PTCH1; CSNK1G3; LRP2A; GSK3AA; DYRK1AA; IHHB; CSNK1A1L; WNT7A
Hippo signaling pathway
YWHAG; FZD5; PPP2R2D; FZD7; CRB1; WNT6; DLG1; BMP8B; APC2; WNT9A
Signaling pathways regulating pluripotency of stem cells
FZD6; KLF4; INHBE; NODAL; BMPR2; WNT2; FGF2; ID3; JARID2; ID4
Melanogenesis
FZD8A; CALM4; FZD7B; CAMK2B1; ADCY1A; HRAS; MAP2K2A; GNAS; WNT3; PRKACBB
Thyroid hormone signaling pathway
EP300; ITGAV; HIF1A; THRA; MED30; AKT1; KAT2A; ATP1A3; WNT4; PRKCA
HTLV-I infection
TNF; HLA-DRB5; TRP53INP1; VCAM1; WNT10B; KAT2A; MSX1; IL15; Il2; ANAPC1
Pathways in cancer
CBLC; WNT9A; FZD8; EGLN3; FN1; FZD1; FH1; STAT3; FIGF; RALBP1
Proteoglycans in cancer
MET; MSN; Casp3; PIK3R3; FLNA; CAV2; PPP1CA; IL12B; WNT8B; DROSHA
Basal cell carcinoma
TP53; LEF1; GLI1; Fzd4; APC; FZD9; FZD3; WNT8B; WNT3; WNT11

Protein Function

WNT4 has several biochemical functions, for example, frizzled binding, receptor agonist activity, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT4 itself. We selected most functions WNT4 had, and list some proteins which have the same functions with WNT4. You can find most of the proteins on our site.
Function
Related Protein
Function frizzled binding
Related Protein WNT1; WNT2; DVL2; DVL1; WNT7AA; SDCBP; WNT8A; WNT6; WNT3; WNT11
Function receptor agonist activity
Related Protein NODAL; VEGFA; WNT5A; WNT3A; SFRP2; WNT1; GAS6; WNT4; WNT2; WNT8A
Function transcription corepressor activity
Related Protein SAP30; JAZF1; DR1; TBL1XR1A; SSX3; NR0B1; HAND1; SETD8; TDP2; CDX2

Interacting Protein

WNT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT4.
P2RX4

WNT4 Related Articles

Morizane, R; Monkawa, T; et al. Kidney Specific Protein-Positive Cells Derived from Embryonic Stem Cells Reproduce Tubular Structures In Vitro and Differentiate into Renal Tubular Cells. PLOS ONE 8:-(2013).
Murugan, S; Shan, JD; et al. WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis. EXPERIMENTAL CELL RESEARCH 318:1134-1145(2012).

WNT4 Related Gene Family

WNT