xpa
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  • Official Full Name
  • xeroderma pigmentosum, complementation group A
  • Background
  • DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene. This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene.
  • Synonyms
  • XPA; xeroderma pigmentosum, complementation group A; DNA repair protein complementing XP-A cells; XP1; XPAC; excision repair-controlling; xeroderma pigmentosum group A-complementing protein
Cat.#:XPA-3751HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XPA, His-tagged
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Cat.#:XPA-7232HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XPA, His-tagged
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Cat.#:XPA-18625MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse XPA Protein
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Cat.#:XPA-6416CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken XPA
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Cat.#:XPA-10771ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish XPA
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Cat.#:XPA-262HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human XPA 293 Cell Lysate
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Involved Pathway

XPA involved in several pathways and played different roles in them. We selected most pathways XPA participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nucleotide excision repair
INO80C; POLD4; YY1A; COPS7B; COPS7A; PPIE; XPC; GTF2H1; POLE4; XPA

Protein Function

XPA has several biochemical functions, for example, damaged DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPA itself. We selected most functions XPA had, and list some proteins which have the same functions with XPA. You can find most of the proteins on our site.
Function
Related Protein
Function damaged DNA binding
Related Protein RPA3; RAD23A; DCLRE1A; RAD23AA; BRCA1; CRY2; OGG1; ERCC4; HMGB1; NEIL1
Function metal ion binding
Related Protein TRIM43B; ARID2; PPM1F; ZNF497; HE1B; ANTXRL; YBEY; IRF2BP2B; CPXCR1; NPTXR
Function protein binding
Related Protein TCEB1; PTPN13; CTNNA2; PARD6B; FAM83A; OCA2; SPRED1; SETX; PLAT; NDOR1
Function protein domain specific binding
Related Protein STXBP1; YWHABB; YWHAE; WNT5A; NEFL; HIST1H4C; CENPJ; YWHABA; ERCC1; STMN3
Function protein homodimerization activity
Related Protein LRRC41; XDH; CAT; HSP90AA1; NR6A1; PLEK; ATF3; CDA; DGAT2; WWTR1

Interacting Protein

XPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPA here. Most of them are supplied by our site. Hope this information will be useful for your research of XPA.
RPA2; SIRT1; ERCC1; TRIM27; NDEL1

XPA Related Articles

Ahmad, I; Simanyi, E; et al. Toll-Like Receptor-4 Deficiency Enhances Repair of UVR-Induced Cutaneous DNA Damage by Nucleotide Excision Repair Mechanism. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:1710-1717(2014).
Aufderklamm, S; Hennenlotter, J; et al. XPA-210: a new proliferation marker determines locally advanced prostate cancer and is a predictor of biochemical recurrence. WORLD JOURNAL OF UROLOGY 30:547-552(2012).