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XPA

Official Full Name

xeroderma pigmentosum, complementation group A
Overview

DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene. This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene.
Synonyms

XPA; xeroderma pigmentosum, complementation group A; DNA repair protein complementing XP-A cells; XP1; XPAC; excision repair-controlling; xeroderma pigmentosum group A-complementing protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	XPA-7232H	Recombinant Human XPA, His-tagged	E.coli	His	1-273aa	Inquiry
Human	XPA-3751H	Recombinant Human XPA, His-tagged	E.coli	His	C-term-273aa	$319 / 25ug
Human	XPA-262HCL	Recombinant Human XPA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	XPA-6719H	Recombinant Human XPA Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	XPA-594H	Recombinant Human XPA Protein, His&GST-tagged	E.coli	N-His&GST	Ser23-Glu271	Inquiry
Mouse	XPA-18625M	Recombinant Mouse XPA Protein	Mammalian Cell	His		Inquiry
Mouse	XPA-10232M-B	Recombinant Mouse XPA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	XPA-10232M	Recombinant Mouse XPA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Xpa-7017M	Recombinant Mouse Xpa Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	XPA-10771Z	Recombinant Zebrafish XPA	Mammalian Cell	His		Inquiry
Chicken	XPA-6416C	Recombinant Chicken XPA	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
XPA Related Articles
XPA Related Research Area

XPA involved in several pathways and played different roles in them. We selected most pathways XPA participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Nucleotide excision repair	GTF2H3;RFC3;COPS6;GTF2H5;ERCC8;GTF2H3-2;RAD23AA;ZNF830;COPS7A

XPA has several biochemical functions, for example, damaged DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPA itself. We selected most functions XPA had, and list some proteins which have the same functions with XPA. You can find most of the proteins on our site.

Function	Related Protein
damaged DNA binding	UNG;NEIL3;OGG1;HMGB1;TP53;RAD23AB;NEIL1;DCLRE1A;POLB
metal ion binding	NT5C;CUBN;CIZ1B;MICALL2B;NUDT10;ZNF177;ROR2;CYP3C4;SKINT8
protein binding	ECD;TAF7L;CDC42EP1;RALY;TMEM171;MAP2K1;CD63;MFN2;CEP72
protein domain specific binding	HOMER2;TADA3;DDX20;KPNB1;ARFIP2B;CSNK2B;CALM;CNTROB;YWHAQA
protein homodimerization activity	NR4A2;CHMP1A;ACOT7;OXCT1;USH1G;Flt3l;EIF2AK3;ADH5;TIGIT

XPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPA here. Most of them are supplied by our site. Hope this information will be useful for your research of XPA.

RPA2; SIRT1; ERCC1; TRIM27; NDEL1

Ahmad, I; Simanyi, E; et al. Toll-Like Receptor-4 Deficiency Enhances Repair of UVR-Induced Cutaneous DNA Damage by Nucleotide Excision Repair Mechanism. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:1710-1717(2014).

Aufderklamm, S; Hennenlotter, J; et al. XPA-210: a new proliferation marker determines locally advanced prostate cancer and is a predictor of biochemical recurrence. WORLD JOURNAL OF UROLOGY 30:547-552(2012).

Nucleotide Excision Repair/Transcription Coupled Repair

DNA Damage and Repair