xpc
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  • Official Full Name
  • xeroderma pigmentosum, complementation group C
  • Background
  • XPC is a component of the nucleotide excision repair (NER) pathway. XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age.
  • Synonyms
  • XPC; xeroderma pigmentosum, complementation group C; DNA repair protein complementing XP-C cells; RAD4; xeroderma pigmentosum group C protein; XPCC; p125; mutant xeroderma pigmentosum group C; XP3
Cat.#:XPC-18626MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse XPC Protein
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Cat.#:XPC-4231ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish XPC
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Involved Pathway

XPC involved in several pathways and played different roles in them. We selected most pathways XPC participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPC were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nucleotide excision repair
COPS7B; POLE2; POLE4; GTF2H2C; KIAA1530; POLD2; YY1; COPS8; CHD1L; COPS5

Protein Function

XPC has several biochemical functions, for example, DNA binding, damaged DNA binding, single-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPC itself. We selected most functions XPC had, and list some proteins which have the same functions with XPC. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF684; ZZZ3; FOXQ2; FOXP1B; IER2; HNRPK; ORC1L; CREMB; NKX2.4A; RUNX1T1
Function damaged DNA binding
Related Protein MPG; RAD52; TRP53; EP300; GTF2H3; XPA; CRY-DASH; RAD23B; OGG1; DCLRE1A
Function single-stranded DNA binding
Related Protein RPA2; PCBP1; NCL; NABP2; XPC; NUP35; MLH3; RAD23A; SSBP1; RAD23B

Interacting Protein

XPC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPC here. Most of them are supplied by our site. Hope this information will be useful for your research of XPC.
Pou5f1; Rad23b; Ywhae

XPC Related Articles

Dreze, M; Calkins, AS; et al. Monitoring Repair of UV-Induced 6-4-Photoproducts with a Purified DDB2 Protein Complex. PLOS ONE 9:-(2014).
Bai, XF; Jin, F; et al. Clinicopathological significance and prognostic value of Xeroderma pigmentosum complementary group C (XPC) expression in sporadic breast cancer patients. MEDICAL ONCOLOGY 29:1543-1553(2012).