YY1
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Official Full Name
YY1 transcription factor -
Overview
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008] -
Synonyms
YY1;YY1 transcription factor;DELTA;NF-E1;UCRBP;INO80S;YIN-YANG-1;transcriptional repressor protein YY1;YY-1;Yin and Yang 1 protein;INO80 complex subunit S;delta transcription factor
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Insect cells
- His
- Non
- Flag
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| YY1-16H | Recombinant Human YY1, His-tagged | E.coli | Human | His | 1-414aa |
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| YY1-18688M | Recombinant Mouse YY1 Protein | Mammalian Cells | Mouse | His |
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| YY1-2674H | Recombinant Human YY1, His-tagged | E.coli | Human | His |
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| YY1-2873C | Recombinant Chicken YY1 | Mammalian Cells | Chicken | His |
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| YY1-31565TH | Recombinant Human YY1 | Wheat Germ | Human | Non | 100 amino acids |
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| YY1-599H | Recombinant Human YY1, FLAG-tagged | E.coli | Human | Flag |
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| YY1-630H | Recombinant Human YY1 Protein, His-tagged | E.coli | Human | His |
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| YY1-632H | Recombinant Human YY1 transcription factor, His-tagged | E.coli | Human | His | 1-414 a.a. |
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| YY1-228HCL | Recombinant Human YY1 293 Cell Lysate | HEK293 | Human | Non |
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| YY1-10272M | Recombinant Mouse YY1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| YY1-10272M-B | Recombinant Mouse YY1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| YY1-12HFL | Recombinant Full Length Human YY1 Protein, N-Flag-tagged | Insect cells | Human | Flag | Full L. |
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Involved Pathway
YY1 involved in several pathways and played different roles in them. We selected most pathways YY1 participated on our site, such as DNA Damage Recognition in GG-NER,DNA Repair,Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | HER9,PSEN2,DLA,HER12,MAML2,DVL1B,RBPJL,HES1,RFNG,JAG2B |
| Global Genome Nucleotide Excision Repair (GG-NER) | INO80,COPS5,USP45,MCRS1,ACTL6A,TFPT,COPS7A,COPS3,PIAS3,PARP2 |
| Delta-Notch Signaling Pathway | SMAD3B,HEY1,ADAM10A,HES6,ASCL1A,MAGEA1,ZFPM1,SAP30,CNTFR,TUBB3 |
| DNA Damage Recognition in GG-NER | PARP2,INO80B,ACTR5,INO80,INO80E,DDB2,COPS7A,COPS4,TFPT,INO80C |
| Nucleotide Excision Repair | COPS3,GTF2H4,TFPT,COPS5,COPS2,COPS4,COPS6,RAD23A,RFC3,ACTR5 |
| DNA Repair | ZFP830,ACTR5,USP43A,MAD2L2,USP10,ELL,UIMC1,TP53BP1,COPS7A,BARD1 |
| Notch-mediated HES/HEY network | CTBP1,GATA1,RCAN1,MYB,MYOD1,HES6,BGLAP,GATA6,ASCL1,HEY1 |
| E2F transcription factor network | CBX5,E2F6,CES1,SMARCA2,CES3,PRMT5,CDKN2C,E2F4,HBP1,CEBPA |
Protein Function
YY1 has several biochemical functions, for example, DNA binding,RNA binding,SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YY1 itself. We selected most functions YY1 had, and list some proteins which have the same functions with YY1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enhancer sequence-specific DNA binding | GATA1,GATA2,GATA4,KLF7B,FOXN4,LDB1,ISL1,SOX11,TWIST1B,LMO4 |
| histone deacetylase binding | RAD9,HDAC10,HDAC3,MYOCD,HOXA10,CEBPA,CEBPB,HDAC6,WDTC1,NIPBL |
| transcription regulatory region DNA binding | SALL3,TCF7L1A,XRCC5,TCF7L1B,SERPINB1A,BCOR,GABPA,WNT11,SOX17,FOXC2 |
| RNA binding | EIF3K,SETD1B,YTHDC1,EIF2S1B,PCBP4,PABPC1A,RNASEH2A,CSTF2,EIF4E1B,MBNL1 |
| four-way junction DNA binding | RAD51,DMC1,RAD51L1,HMGB2,RAD51L3,HMGB3,HMGB1,MEN1 |
| transcription corepressor activity | SSX5,KCTD1,IRF2BP2,ZMYND11,YWHAB,WNT4,LDB1,ANKRD1,TMEM38A,BCOR |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | NKX6-2,ZFPM2A,AEBP2,SPI1,HINFP,RCOR1,ZFP90,GZF1,TFAP2C,BCL11AB |
| DNA binding | ZNF692,TLR8,MKXB,PDCD2,HOXD4A,GCM2,ZNF225,PIAS1,NKX2.3,HOXD13A |
| transcription factor activity, sequence-specific DNA binding | NKX2,SLAMF7,DMRT2,GATA2B,SOX9,CRX,TP73,TLX2,HIVEP2A,THRAA |
Interacting Protein
YY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YY1.
ACTL6A;E1A;ARRB1;INO80;RUVBL2
Resources
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References
- Kang, W; Tong, JHM; et al. Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
