yy1
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  • Official Full Name
  • YY1 transcription factor
  • Background
  • YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
  • Synonyms
  • YY1; YY1 transcription factor; DELTA; NF-E1; UCRBP; INO80S; YIN-YANG-1; transcriptional repressor protein YY1; YY-1; Yin and Yang 1 protein; INO80 complex subunit S; delta transcription factor;
Cat.#:YY1-16HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1, His-tagged
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Cat.#:YY1-2674HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1, His-tagged
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Cat.#:YY1-31565THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human YY1
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Cat.#:YY1-599HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1, FLAG-tagged
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Cat.#:YY1-630HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1 Protein, His-tagged
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Cat.#:YY1-632HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1 transcription factor, His-tagged
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Cat.#:YY1-18688MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse YY1 Protein
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Cat.#:YY1-2873CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken YY1
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Cat.#:YY1-228HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human YY1 293 Cell Lysate
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Involved Pathway

YY1 involved in several pathways and played different roles in them. We selected most pathways YY1 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YY1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA Damage Recognition in GG-NER
PARP2; MCRS1; PARP1; COPS6; CETN2; COPS7B; DDB2; COPS3; INO80; INO80C
DNA Repair
USP43; EYA2; THRSP; YY1A; ALKBH2; PAXIP1; PPIE; ASCC2; USP10; TOPBP1
Delta-Notch Signaling Pathway
HES6; SAP30; HEY1; JAG2; ASCL1; WDR12; HEY2; APPA; YY1; ASCL1A
E2F transcription factor network
RYBP; UXT; CDKN2C; CBX5; HBP1; PRMT5; CES1; TRIM28; CES5A; SMARCA2
Global Genome Nucleotide Excision Repair (GG-NER)
PARP2; COPS2; INO80E; YY1A; COPS4; TFPT; CHD1L; YY1; COPS8; COPS3
Notch signaling pathway
ADAM17A; CIR1; JAG1B; KAT2A; HER15.1; CNTN6; PSEN2; PSEN1; ADAM17; JAG1A
Notch-mediated HES/HEY network
ASCL1; BGLAP; GATA6; HES6; MYOD1; YY1; RCAN1; CTBP1; GATA1; MYB
Nucleotide Excision Repair
ERCC6; COPS8; GTF2H2C; YY1A; PPIE; COPS2; RAD23AB; NFRKB; ERCC8; INO80B

Protein Function

YY1 has several biochemical functions, for example, DNA binding, RNA binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YY1 itself. We selected most functions YY1 had, and list some proteins which have the same functions with YY1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein TP53; PRDM4; HOXC12A; TRIM28; OTX1A; POU3F3; ZNF333; PTF1A; SP100; ARID3C
Function RNA binding
Related Protein SRSF12; EXOSC9; PRPF6; HNRNPA1; RBM4.1; RPS9; RBMY1F; ZNF74; NCBP1; UBR5
Function SMAD binding
Related Protein TGFBRAP1; FKBP1A; TCF12; TGFBR2; COL1A2; SKOR1; PRDM16; STUB1; TGFBR1; BMPR1A
Function enhancer sequence-specific DNA binding
Related Protein XBP1; KLF7B; MYT1; KLF6A; FOXN4; TFAP2B; ISL1; LMO4; GATA3; HMGB2
Function four-way junction DNA binding
Related Protein YY1; HMGB2; HMGB3; MEN1; RAD51; HMGB1; RAD51L1; RAD51L3; DMC1
Function histone deacetylase binding
Related Protein HIST1H1B; WDTC1; BCOR; FOXP3; USF1; NCOR1; BRMS1LA; PKN1; SP1; TCF21
Function protein binding
Related Protein RNF149; RASL11A; KRTAP4-12; SRF; TJAP1; HTR3A; IRF2; TMEM120B; RPS2; CUL1
Function transcription coactivator activity
Related Protein TFDP1; PML; SRA1; KMT2E; ACTL6A; SUPT3H; TFAP2A; TUBB3; JUND; MAML2
Function transcription corepressor activity
Related Protein KCNA3; NAB2; SAP30; ZHX1; SUFU; TBL1Y; RUNX1T1; TOB1; TSG101; SAP18
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZSCAN20; FOXP3A; FOXA2; NFIXB; ZFP110; ZFP42; ESR2; HOXB4; SIM1; PRRXL1
Function transcription regulatory region DNA binding
Related Protein IKZF1; GATA5; SMAD4; HNRNPL; ZNF821; TP63; TBX21; SALL4; SMAD7; Ar
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NFIL3-4; ATF3; HINFP; NFIL3; ZBTB7A; KCNIP3; NKX6; SALL1; BATF3; KLF17
Function zinc ion binding
Related Protein LIMD1; ADAMTSL1; MIB2; RFPL3; NR1D2; MARCH5; LMO7B; KDM7AB; FBXO30A; CPN1

Interacting Protein

YY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YY1.
ACTL6A; E1A; ARRB1; INO80; RUVBL2

YY1 Related Articles

Hasanali, ZS; Epner, EM; et al. Vorinostat Downregulates CD30 and Decreases Brentuximab Vedotin Efficacy in Human Lymphocytes. MOLECULAR CANCER THERAPEUTICS 13:2784-2792(2014).
Kang, W; Tong, JHM; et al. Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).