yy1
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  • Official Full Name
  • YY1 transcription factor
  • Background
  • YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
  • Synonyms
  • YY1; YY1 transcription factor; DELTA; NF-E1; UCRBP; INO80S; YIN-YANG-1; transcriptional repressor protein YY1; YY-1; Yin and Yang 1 protein; INO80 complex subunit S; delta transcription factor;
Cat.#:YY1-16HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1, His-tagged
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Cat.#:YY1-2674HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1, His-tagged
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Cat.#:YY1-31565THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human YY1
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Cat.#:YY1-599HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1, FLAG-tagged
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Cat.#:YY1-630HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1 Protein, His-tagged
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Cat.#:YY1-632HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YY1 transcription factor, His-tagged
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Cat.#:YY1-18688MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse YY1 Protein
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Cat.#:YY1-2873CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken YY1
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Cat.#:YY1-228HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human YY1 293 Cell Lysate
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Involved Pathway

YY1 involved in several pathways and played different roles in them. We selected most pathways YY1 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YY1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA Damage Recognition in GG-NER
INO80E; DDB1; ACTL6A; INO80; PARP1; COPS3; INO80C; ACTR5; TFPT; DDB2
DNA Repair
TDP2; RIF1; INO80E; SMARCA5; APITD1; PPP4CA; RAD9A; PPIE; COPS7B; CHEK1
Delta-Notch Signaling Pathway
YY1; CNTN1; YY1A; SAP30; HIVEP3; NOV; ZFPM1; CNTN1B; RING1; WDR12
E2F transcription factor network
SMARCA2; CEBPA; E2F6; CES1; DHFR; RYBP; TRIM28; RBBP8; CES3; HBP1
Global Genome Nucleotide Excision Repair (GG-NER)
COPS7B; INO80; GPS1; COPS4; USP45; YY1; TFPT; PARP2; COPS7A; MCRS1
Notch signaling pathway
APH1C; TUBB3; NOTCH3; PSENEN; ADAM12; DTX4; HER12; KAT2A; RBPJL; JAG1B
Notch-mediated HES/HEY network
ASCL1; YY1; MYB; HES6; TLE1; MYOD1; HEY1; CTBP1; GATA1; GATA6
Nucleotide Excision Repair
GTF2H2; INO80B; COPS7A; BIVM-ERCC5; INO80C; GTF2H3; POLD4; RAD23AB; LIG1; CHD1L

Protein Function

YY1 has several biochemical functions, for example, DNA binding, RNA binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YY1 itself. We selected most functions YY1 had, and list some proteins which have the same functions with YY1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NKX6-1; ALX3; ESRRGA; ZNF280B; ZNF84; ERCC2; MECP2; DHX58; MYCS; HOMEZA
Function RNA binding
Related Protein ZNF638; KHDC1C; RNMTL1B; UPF1; PPP5C; OAS1B; RPL31; DDX25; PKZ; LIN28A
Function SMAD binding
Related Protein MEF2A; FOXH1; TGFBRAP1; FKBP1A; PML; EID2; TGFBR1; SKIB; ACVR1B; SKIA
Function enhancer sequence-specific DNA binding
Related Protein TFAP2B; YY1; TBX19; XBP1; TWIST1B; ISL1; SOX9; GATA4; LDB1; KLF7B
Function four-way junction DNA binding
Related Protein HMGB2; YY1; HMGB3; RAD51L3; RAD51; RAD51L1; DMC1; MEN1; HMGB1
Function histone deacetylase binding
Related Protein TAL1; PKN1; ZNF703; USF1; KLF4; KAT2B; ZFP932; YY1; HDAC9; MAPK8
Function protein binding
Related Protein SMU1; TOR1A; BRD8; CCPG1; CBX3; RUNX3; HTR3E; GSS; CLK2; PRKD1
Function transcription coactivator activity
Related Protein SCAND1; PSMD9; GTF2F1; MED20; CRSP7; HTATIP2; NCOA4; RNF14; NPAT; LPIN3
Function transcription corepressor activity
Related Protein HOXC6; CBX4; CIR1; CCND1; E2F7; PBXIP1; RUNX1T1; KDM5B; KCNIP3; LIMD1
Function transcription factor activity, sequence-specific DNA binding
Related Protein SOX11B; TAF13; SMAD1; ZNF613; TSC22D2; TWIST2; KLF9; SLAMF7; CREB3L3A; ZNF480
Function transcription regulatory region DNA binding
Related Protein POU5F1; SALL1; TCF7L1B; HINFP; MEN1; ZFHX3; HNRNPL; TCF7; FOXH1; SOX17
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein POU4F2; SREBF2; SNAI2; BCL11AA; ATF3; BCL11AB; ZKSCAN3; TCF3; NEUROG3; CTCF
Function zinc ion binding
Related Protein MMP26; ZDHHC15B; VPS8; TRIM8A; GTF2H2C_2; ZNF84; GATA4; CAHZ; FHL5; MEP1A

Interacting Protein

YY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YY1.
ACTL6A; E1A; ARRB1; INO80; RUVBL2

YY1 Related Articles

Hasanali, ZS; Epner, EM; et al. Vorinostat Downregulates CD30 and Decreases Brentuximab Vedotin Efficacy in Human Lymphocytes. MOLECULAR CANCER THERAPEUTICS 13:2784-2792(2014).
Kang, W; Tong, JHM; et al. Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).