ZEB1
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Official Full Name
zinc finger E-box binding homeobox 1
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Overview
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
ZEB1; zinc finger E-box binding homeobox 1; posterior polymorphous corneal dystrophy 3 , PPCD3, TCF8, transcription factor 8 (represses interleukin 2 expression); zinc finger E-box-binding homeobox 1; AREB6; BZP; NIL 2 A; ZEB; Zfhep; Zfhx1a; AREB 6; DELTA EF1; MGC133261; Negative regulator of IL 2; Negative regulator of IL2; NIL 2 A zinc finger protein; NIL 2A; NIL-2-A zinc finger protein; NIL2A; Represses interleukin 2 expression; TCF 8; TCF-8; TCF8; Transcription factor 8 (represses interleukin 2 expression); Transcription factor 8; ZEB 1; ZEB1_HUMAN; ZFHX 1A; Zinc finger E box binding homeobox 1; Zinc finger homeodomain enhancer binding protein; OTTHUMP00000019404; OTTHUMP00000019405; OTTHUMP00000019406; delta-crystallin enhancer binding factor 1; posterior polymorphous corneal dystrophy 3; zinc finger homeodomain enhancer-binding protein; FECD6; PPCD3; DELTAEF1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ZEB1-3796H | Recombinant Human ZEB1, GST-tagged | E.coli | GST | 391-740aa | |
| Human | ZEB1-22H | Recombinant Human ZEB1 Protein, GST-tagged | Wheat Germ | GST | 801 a.a. - 900 a.a. |
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| Human | ZEB1-190HCL | Recombinant Human ZEB1 293 Cell Lysate | HEK293 | N/A |
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| Human | ZEB1-604H | Recombinant Human ZEB1 Protein, His-tagged | E.coli | N-His | Tyr904-Ala1124 |
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| Mouse | ZEB1-18798M | Recombinant Mouse ZEB1 Protein | Mammalian Cell | His |
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| Mouse | ZEB1-10324M | Recombinant Mouse ZEB1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ZEB1-10324M-B | Recombinant Mouse ZEB1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | ZEB1-6688C | Recombinant Chicken ZEB1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ZEB1 Related Articles
- ZEB1 Related Research Area
ZEB1 involved in several pathways and played different roles in them. We selected most pathways ZEB1 participated on our site, such as Transcriptional misregulation in cancer, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZEB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | HOXA9;ETV1;RXRG;BCL6;DDX5;RELA;Pdgfa&Pdgfb;ETV7;NFKB1 |
| MicroRNAs in cancer | SLC7A1;SIRT1;HMOX1;APC;KIF23;WNT3A;PRKCA;TRP53;STAT3 |
ZEB1 has several biochemical functions, for example, E-box binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZEB1 itself. We selected most functions ZEB1 had, and list some proteins which have the same functions with ZEB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| E-box binding | ATOH8;NEUROD1;GATA3;ARNTL2;NEUROD2;ZEB1;TAL1;MYC;TCF3 |
| chromatin binding | SMARCD1;NEUROD1;BRD2;SOX10;RNF168;GPR30;KLHDC3;STAG2;GATA6 |
| protein binding | FBXL12;DLG4;CLEC16A;CD82;RBM39;HSF1;CHID1;HTRA3;KHDC1A |
| transcription coactivator activity | CDK7;CALCOCO1;CITED4;MYOCD;ATF6;CTBP2;NFATC4;VGLL1;ARNT |
| transcription corepressor activity | HEYL;ZHX1;HDAC3;SSX5;NPAT;WNT4;TFAP2B;E4F1;MXD1 |
| transcription factor activity, sequence-specific DNA binding | ZFP14;RXRB;REST;SALL4;GATA5;HSFY1;E2F5;BHLHE40;ZNF202 |
| transcription factor binding | FOXF2;ARID5A;MYC;SRY;HTT;NBN;ERCC3;MYOD1;KEAP1B |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | KLF6A;FOXO3;ISX;HIST2H3A;ZNF350;HMX1;SATB1;ZC3H8;E2F7 |
| zinc ion binding | SEC24C;RNF169;BHMT;ZCCHC3;BRF1;NR2E3;SMAD3;RNF26;TCEA1 |
ZEB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZEB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZEB1.
CDK6; CTBP1; yscH; ifnl1_human_gene; SYNCRIP
- Q&As
- Reviews
Q&As (5)
Ask a questionClinical studies have indicated a correlation between high ZEB1 expression and reduced overall survival rates in cancer patients.
Some research is focused on developing inhibitors targeting ZEB1 as potential therapeutic agents, although this area is still in the early stages.
ZEB1 promotes the invasion and metastasis of cancer cells by inducing EMT, allowing cells to acquire a more migratory and invasive phenotype.
Targeting ZEB1 for personalized medicine approaches is an area of active research, exploring its potential as a specific therapeutic target based on individual patient profiles.
Emerging evidence suggests that assessing ZEB1 expression levels may have diagnostic potential, especially in identifying early stages of certain cancers.
Customer Reviews (3)
Write a reviewThey provide comprehensive assistance, ensuring that any queries or concerns I have regarding the ZEB1 protein are promptly addressed.
One of the standout advantages offered by the manufacturer is their excellent technical support.
They continuously stay up-to-date with the latest scientific advancements and customer feedback, allowing them to refine the ZEB1 protein based on emerging trends.
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