ZIC2 Protein, zinc finger protein of the cerebellum 2


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Official Full Name zinc finger protein of the cerebellum 2
Background ZIC2 (zinc finger protein of the cerebellum 2) is a transcriptional repressor and may regulate tissue specific expression of the dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.
Synonyms Zic2; zinc finger protein of the cerebellum 2; Ku; HPE5; zinc finger protein ZIC 2; kumba; GENA 29; OTTMUSP00000022013; odd-paired homolog; Zic family member 2 (odd-paired homolog, Drosophila); Zinc Finger Protein of Cerebellum 2
    • Species :
    • Human
    • Source :
    • HEK293
    • Tag :
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ZIC2-166HCL Recombinant Human ZIC2 293 Cell Lysate HEK293 N/A
    Human ZIC2-439H Recombinant Human ZIC2 Protein, MYC/DDK-tagged HEK293 Myc/DDK

    ZIC2 involved in several pathways and played different roles in them. We selected most pathways ZIC2 participated on our site, such as Hedgehog signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog signaling pathway WNT9B; CSNK1G2B; PRKACB; WNT16; PRKACA; Shh; SHHA; GSK3AA; SHHB; WNT3A

    ZIC2 has several biochemical functions, for example, DNA binding, chromatin DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIC2 itself. We selected most functions ZIC2 had, and list some proteins which have the same functions with ZIC2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding SOX15; ZBTB18; POLR2J; FOXB1A; LEMD3; EXO5; IRX3A; POLE; ZNF10; KLF3
    chromatin DNA binding ZIC2; MED1; BCL6; WBP2; RXRA; VAX1; EP300; THRB; ATOH1; HIST1H1C
    metal ion binding Alb; ZC3H7A; ZSCAN4C; RPS27A; JMJD5; GUCA1D; ZNF691; MICALL2B; PPM1LA; ZNF460
    transcription factor activity, sequence-specific DNA binding HIF1A; DLX6; INSM1A; RFX8; SMAD7; MLXIPL; TAF1B; SP1; POU2F1; EOMES

    ZIC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZIC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZIC2.


    Sakuma, K; Kasamatsu, A; et al. Expression status of Zic family member 2 as a prognostic marker for oral squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 136:553-559(2010).
    Aruga, J; Nozaki, Y; et al. Expression of ZIC family genes in meningiomas and other brain tumors. BMC CANCER 10:-(2010).

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