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ZIC2

Official Full Name

zinc finger protein of the cerebellum 2
Overview

ZIC2 (zinc finger protein of the cerebellum 2) is a transcriptional repressor and may regulate tissue specific expression of the dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.
Synonyms

Zic2; zinc finger protein of the cerebellum 2; Ku; HPE5; zinc finger protein ZIC 2; kumba; GENA 29; OTTMUSP00000022013; odd-paired homolog; Zic family member 2 (odd-paired homolog, Drosophila); Zinc Finger Protein of Cerebellum 2;

Type

Cell & Tissue Lysates
Recombinant Proteins

Species

Human
Mouse

Source

E. coli
E.coli
HEK293
HEK293T

Tag

C
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ZIC2-166HCL	Recombinant Human ZIC2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ZIC2-774H	Recombinant Human ZIC2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	ZIC2-2492H	Recombinant Human ZIC2 protein(271-450 aa), C-His-tagged	E. coli	C-His	271-450 aa	Inquiry
Human	ZIC2-439H	Recombinant Human ZIC2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	ZIC2-1416H	Recombinant Human ZIC2 protein, His-tagged	E.coli	His	100-415aa	Inquiry
Mouse	Zic2-7109M	Recombinant Mouse Zic2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ZIC2 Related Articles

ZIC2 involved in several pathways and played different roles in them. We selected most pathways ZIC2 participated on our site, such as Hedgehog signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hedgehog signaling pathway	Shh;DYRK1A;IHHB;WNT16;WNT11R;GLI2B;CSNK1DA;SHHA;SKI

ZIC2 has several biochemical functions, for example, DNA binding, chromatin DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIC2 itself. We selected most functions ZIC2 had, and list some proteins which have the same functions with ZIC2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ASXL1;DR1;EMX1;ZNF34;ASH2L;SP5;RNF4;RPS15;NKX2-5
chromatin DNA binding	NKAP;SLAMF7;APEX1;THRB;VAX2;EZH2;CLOCK;ATOH1;SRF
metal ion binding	ZNF227;PPARDB;ZNF155;RASA4;GIT2A;RASA3;SLC25A25A;SIRT4;PPM1BA
transcription factor activity, sequence-specific DNA binding	NR2F5;NR1D1;ATF5A;NFIL3-3;ZFP641;FOXC1;ZFP322A;TBX2A;SPIB

ZIC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZIC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZIC2.

PRKDC

Sakuma, K; Kasamatsu, A; et al. Expression status of Zic family member 2 as a prognostic marker for oral squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 136:553-559(2010).

Aruga, J; Nozaki, Y; et al. Expression of ZIC family genes in meningiomas and other brain tumors. BMC CANCER 10:-(2010).