| Description : |
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
54.8 kDa |
| AA Sequence : |
MLLDAGPQFPAIGVGSFARHHHHSA AAAAAAAAEMQDRELSLAAAQNGFV DSAAAHMGAFKLNPGAHELSPGQSS AFTSQGPGAYPGSAAAAAAAAALGP HAAHVGSYSGPPFNSTRDFLFRSRG FGDSAPGGGQHGLFGPGAGGLHHAH SDAQGHLLFPGLPEQHGPHGSQNVL NGQMRLGLPGEVFGRSEQYRQVASP RTDPYSAAQLHNQYGPMNMNMGMNM AAAAAHHHHHHHHHPGAFFRYMRQQ CIKQELICKWIDPEQLSNPKKSCNK TFSTMHELVTHVSVEHVGGPEQSNH VCFWEECPREGKPFKAKYKLVNHIR VHTGEKPFPCPFPGCGKVFARSENL KIHKRTHTGEKPFQCEFEGCDRRFA NSSDRKKHMHVHTSDKPYLCKMCDK SYTHPSSLRKHMKVHESSPQGSESS PAASSGYESSTPPGLVSPSAEPQSS SNLSPAAAAAAAAAAAAAAAVSAVH RGGGSGSGGAGGGSGGGSGSGGGGG GAGGGGGGSSGGGSGTAGGHSGLSS NFNEWYVTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
