In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5 exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5 alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene.
ZIM2 involved in several pathways and played different roles in them. We selected most pathways ZIM2 participated on our site, such as Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
ZIM2 has several biochemical functions, for example, DNA binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIM2 itself. We selected most functions ZIM2 had, and list some proteins which have the same functions with ZIM2. You can find most of the proteins on our site.
Function DNA binding
Related Protein ARID5B; PA2G4; WDHD1; AGFG1; TCF25; NR1D2B; ARHGAP35; ZFP507; GSX2; H2AFB2
Function zinc ion binding
Related Protein MMP2; CA5A; TRIM2; NR4A3; DTX4; PMPCB; GATA4; ADAM10A; MMP28; MYLIPB