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Official Full Name ATP-binding cassette, sub-family B (MDR/TAP), member 11
Background The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
Synonyms ABCB11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; bile salt export pump , BSEP, PFIC2, progressive familial intrahepatic cholestasis 2; bile salt export pump; ABC member 16; MDR/TAP subfamily; ABC16; PFIC 2; PGY4; SPGP; sister p-glycoprote
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABCB11-2532H Recombinant Human ABCB11 Sf9 Insect Cell N/A
    Human ABCB11-8135H Recombinant Human ABCB11 protein, His & T7-tagged E.coli His/T7
    Mouse ABCB11-1088M Recombinant Mouse ABCB11 Protein Mammalian Cell His
    Mouse Abcb11-8136M Recombinant Mouse Abcb11 protein, His & T7-tagged E.coli His/T7
    Rat ABCB11-396R Recombinant Rat ABCB11 Protein Mammalian Cell His

    abcb11 involved in several pathways and played different roles in them. We selected most pathways abcb11 participated on our site, such as ABC transporters, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with abcb11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC transporters ABCB7; ABCC6; ABCC1; ABCB1A; ABCA3; CFTR; ABCC9; ABCA4; ABCA1B; ABCA13
    Bile secretion BAAT; ABCG2; ATP1A1; SLCO1A4; PRKACA; SLC9A1; ABCC2; NR1H4; FAM84B; OSTB

    abcb11 has several biochemical functions, for example, ATP binding, bile acid-exporting ATPase activity, canalicular bile acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by abcb11 itself. We selected most functions abcb11 had, and list some proteins which have the same functions with abcb11. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MYH10; CDK19; ABCC10; MAPK3; AURKA; UCKL1; THRAP3; NLRP14; KCNJ8; PRKD3
    bile acid-exporting ATPase activity ABCB11
    canalicular bile acid transmembrane transporter activity ABCB11
    sodium-exporting ATPase activity, phosphorylative mechanism ABCB11
    transporter activity TTPA; ABCA5; CPNE6; STEAP1; AQP9B; SLCO1A6; SLC51A; SLC2A13B; LCN2; OSTB

    abcb11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with abcb11 here. Most of them are supplied by our site. Hope this information will be useful for your research of abcb11.

    NR4A1; LY6D

    Jungst, C; Lammert, F; et al. Cholestatic Liver Disease. DIGESTIVE DISEASES 31:152-154(2013).

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