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Recombinant Mouse ABCB11 Protein

Cat.No. : ABCB11-1088M
Product Overview : Recombinant Mouse ABCB11 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 [ Mus musculus ]
Official Symbol : ABCB11
Gene ID : 27413
mRNA Refseq : NM_021022.3
Protein Refseq : NP_066302.2
MIM :
UniProt ID : Q9QY30

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (30)

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How many mutants were found in ABCB11? 04/14/2023

About 200 missense mutations in ABCB11 have been reported.

Which mutant most frequently happen in ABCB11? 04/14/2023

The frequencies of ABCB11 mutations differ between Asian and European populations. ABCB11 mutation c.386G>A (p.C129Y) that is most frequently reported in Japan.

If two patients have same ABCB11 mutant genotype, will they have the same phenotype? 04/14/2023

No, The clinical manifestations of ABCB11 deficiency may vary greatly in patients carrying the same genotype, even in siblings.

Dose ABCB11 mutant related with intrahepatic cholestasis? 04/14/2023

The common variant p.Val444Ala in ABCB11 confers increased risk of drug-induced liver injury and intrahepatic cholestasis of pregnancy (ICP).

Where does BSEP most locate? 04/14/2023

Bile salt export pump (BSEP/ABCB11), a member of the family of ATP-binding cassette transporters, is localized on the canalicular membrane of hepatocytes and mediates the efficient biliary excretion of bile acid.

Which proteins are related with Progressive Familial Intrahepatic Cholestasis? 04/14/2023

The major PFIC genes are now described. ATP8B1 encodes FIC1, ABCB11 encodes BSEP, ABCB4 encodes MDR3, TJP2 encodes TJP2, NR1H4 encodes FXR, and MYO5B encodes MYO5B.

Could microRNA inhibit ABCB11? 04/14/2023

Yes, there many inhibitors could inhibit ABCB11. For example, miR-199a-5p would target the 3'-untranslated region (3'-UTR) of ABCB11/Abcb11 mRNA, and inhibits the expression of ABCB11 in obstructive cholestasis

What's the phenotype of ABCB11 deficiency? 04/14/2023

The clinical manifestations of ABCB11 deficiency may vary greatly in patients carrying the same genotype. Patients should be managed in individualized maner.

Does anyone have the Cryo-EM structure of human bile salts exporter ABCB11? 04/14/2023

You could find the result in the Cell Research, https://www.nature.com/articles/s41422-020-0302-0

Do genetic variants of BSEP(ABCB11) and MDR3 play a key role in primary biliary cirrhosis (PBC) and primary sclerosing cholangitis? 04/14/2023

Some studies show that although an impact of rare variants on BSEP and MDR3 function cannot be ruled out, the data do not support a strong role of BSEP and MDR3 genetic variations in the pathogenesis of PBC and PSC.

What is the full meaning of BSEP? 04/14/2023

ABCB11, more commonly referred to as BSEP (Bile Salt Export Pump) is a uni-directional, ATP-dependent efflux transporter that plays an important role in the elimination of bile salts from the hepatocyte into the bile canaliculi for export into the gastrointestinal tract (GIT).

I have a set of mutations in ABCB11 gene and wish to analyse the effect on the BSEP protein that it encodes for. How could I do? 04/14/2023

Homology modelling is useful for you, but you should have a structure of the wild-type protein first.

The ABCC11 gene determines whether you have wet earwax and body odor, or dry earwax and no body odor. Could it possible that I have strong body odor but also dry earwax? 04/14/2023

You can find the cell line in ATCC. Or contact us directly for more information.

What drugs activate ABCB11 to inhibit bile salt transport? 03/11/2022

Rifampicin and glibenclamide inhibit bile salt transport by ABCB11.

What family does ABCB11 belong to? 09/30/2021

ABCB11 belongs to the B subfamily of ABC transporters. It shows high sequence and structural homology to the multidrug transporter P-glycoprotein (P-gp,MDR1,ABCB1); thus, BSEP was originally named sister of P-gp or Spgp.

Which substrate has the highest affinity for ABCB11? 08/12/2021

The substrate with the highest affinity for human BSEP is taurocholic acid (TC), and the substrate with the highest affinity for mouse BSEP is taurochenodeoxycholic acid (TCDC).

By whom is ABCB11 expression regulated during and after transcription? 03/07/2021

When activated by bile salts, FXR forms a heterodimer with the retinoid X receptor (RXR). The FXR–RXR complex enhances transcription from the ABCB11 promoter.

what are the ABCB11 structural characteristics? 07/14/2020

Similar to P-glycoprotein, BSEP possesses a canonical ABC transporter membrane topology, having a domain order of TMD1-NBD1-TMD2-NBD2, as well as containing a large, heavily glycosylated extracellular loop in the first TMD, between TMH1 and TMH2.

What the protein of ABCB11 mainly transports? 06/05/2020

It mainly transports primary conjugated bile acids, including glycocholic acid(GC), taurocholic acid(TC), glycochenodeoxycholic acid(GCDC), and taurochenodeoxycholic acid(TCDC).

Which drugs up-regulate mRNA and protein levels of ABCB11? 05/10/2020

Drugs such as Corilagin, Emodin, Geniposidic acid, Auraptene.

Why is ABCB11 a target for many drugs to treat cholestasis? 03/31/2020

Because FXR controls the synthesis, transport, and metabolism of BAs, and upregulates ABCB11 and multidrug resistance-associated protein 2(MRP2) to promote the secretion of BAs.

Why the ABCB11 is the only protein in the liver that has bile salt transport function? 01/13/2019

The fact that mutations in the ABCB11 gene in PFIC2 patients lead to extremely low biliary bile salt concentrations (<1% of normal).

When the bile salt level in hepatocytes increases, can ABCB11 level be adjusted to restore the normal bile salt level? 01/03/2019

When bile salt levels become elevated in hepatocytes, upregulating ABCB11 expression increases the eff lux of bile salts from hepatocytes to normalize cellular levels of bile salts.

What are the regulatory mechanisms of ABCB11 expression and function? 08/14/2018

The regulatory mechanism of BSEP expression and function can be briefly divided into two categories: transcriptional and post-transcriptional BSEP regulation.

What happens if the ABCB11 structure is modified or its function is suppressed? 04/19/2018

If the ABCB11 structure is modified or its function is inhibited; the liver can accumulate excessive bile. This affects the regeneration of liver tissue and glucose homeostasis, leads to atherosclerosis, and even causes cancer.

To what gene is jaundice in infants commonly thought to be related and to have persistent and worsening liver disease? 03/11/2018

Infants with jaundice associated with ABCB11 mutations are thought generally to have liver disease that persists and worsens.

What diseases might be caused by the defect in ABCB11? 01/25/2018

Defects in ABCB11,cause progressive familial intrahepatic cholestasis (PFIC), a heterogeneous group of rare, autosomal recessive liver diseases of childhood.

What type of protein is ABCB11 and what does it do? 09/14/2017

The bile salt export pump (BSEP/ABCB11) is a liver-resident transporter protein,which plays an essential role in the enterohepatic circulation of the bile salts.

How does bile salt enter liver cells and then be secreted out of the cell? 04/08/2017

The bile acid(BA) that is exported to the intestine can be reabsorbed in the terminal ileum and returned to the liver through the portal vein system and enter the liver cells via the Na+ dependent taurocholic cotransporting polypeptide (NTCP) on the hepatocyte basolateral plasma membrane.They are subsequently secreted into the bile canaliculi through the bile salt export pump (BSEP) on the apical membrane of hepatocytes.

Who is the only protein in the liver with bile salt transport function? 11/07/2016

Secretion of bile salts by ABCB11 is essential for bile flow and for absorption of lipids and fat-soluble vitamins.

Customer Reviews (3)

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Reviews
01/11/2021

    Good for western blot control.

    01/09/2018

      The quality of protein is very good

      01/02/2017

        Used in protein electron microscopy structure analysis.Great.

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