ABCC12
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
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Overview
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. -
Synonyms
ABCC12; ATP-binding cassette, sub-family C (CFTR/MRP), member 12; multidrug resistance-associated protein 9; MRP9; ATP-binding cassette sub-family C member 12; ATP-binding cassette transporter sub-family C member 12; MGC27071;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Mouse
- Rat
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Mouse | ABCC12-1099M | Recombinant Mouse ABCC12 Protein | Mammalian Cell | His |
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| Mouse | ABCC12-196M | Recombinant Mouse ABCC12 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ABCC12-196M-B | Recombinant Mouse ABCC12 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ABCC12-403R | Recombinant Rat ABCC12 Protein | Mammalian Cell | His |
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| Rat | ABCC12-58R | Recombinant Rat ABCC12 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ABCC12-58R-B | Recombinant Rat ABCC12 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
ABCC12 involved in several pathways and played different roles in them. We selected most pathways ABCC12 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCD3;ABCA1;ABCB4;ABCC5;ABCA3;ABCA8;ABCD4;TAP1;ABCG5 |
ABCC12 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC12 itself. We selected most functions ABCC12 had, and list some proteins which have the same functions with ABCC12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ERBB4;DYRK1B;TARS;CASKB;FGFR1B;GALK1;ATRX;SLFNL1;DDX58 |
| ATPase activity | KIFC3;KIF13B;ABCA1B;ABCC5;CLPX;HSPD1;MYH9;ABCD3A;DYNC1H1 |
| ATPase activity, coupled to transmembrane movement of substances | ABCC8;ABCA3;ABCB6A;ABCA4A;ABCA1B;ABCG8;Abcb1b;ABCC9;ABCB10 |
| nucleotide binding | RBM46;DND1;IFT22;TGFBR1A;WNK2;ZFML;RBMX;RHOU;HRASB |
ABCC12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC12.
- Q&As
- Reviews
Q&As (10)
Ask a questionThe closest homologue of MRP5 is MRP9/ABCC12, which does not exist in Caenorhabditis elegans, improving the possibility that MRP9 may compensate MRP5 genetically. MRP5 and MRP9 play a synergistic role in regulating male reproductive function and mitochondrial adequacy.
Relative to the normal liver tissue, mRNA expression of ABCC1/2/3/4/5/6/10 was significantly upregulated (P < .001), and that of ABCC9/11 significantly downregulated (both P < .001), in LIHC.
It can transport nitrogen, and its expression is up-regulated under low nitrogen conditions
ABCC12 encodes multidrug resistance-associated protein 9 (MRP9) that belongs to the adenosine 5'-triphosphate-binding cassette transporter C family with unknown function and no previous implication in liver disease. But recent study shows that Immunohistochemistry and Western blotting revealed conserved MRP9 protein expression in the bile ducts in human, mouse, and zebrafish. Zebrafish abcc12-null mutants were prone to cholangiocyte apoptosis, which caused progressive bile duct loss during the juvenile stage.
Single-nucleotide polymorphisms in ABCC12, SLC28A1, and PPARD were associated with varied responses, which warrants further investigation to determine their effect on spasticity.
Yes,different variants have different function. Four splicing variants encoding putatively short peptides were predominant in ABCC12 gene transcripts. Those splicing variants may represent diverse biological functions of these ABC transporter genes.
In mouse and boar sperm, Mrp9 localizes to the midpiece, a structure containing all sperm mitochondria. However, immunolocalization microscopy and cell fractionation studies with transfected HEK-293 cells and mouse testis show that MRP9/Mrp9 does not localize to mitochondria. In HEK-293 cells, it is predominantly localized in the endoplasmic reticulum.
The human MRP/ABCC transporters except MRP9/ABCC12 are all able to transport organic anions, such as drugs conjugated to glutathione, sulphate or glucuronate.
Yes,phylogenetic analysis confirmed that ABCC11 and ABCC12 were derived through replication and were most closely related to ABCC5 gene.
The transcripts ABCC12 genes were detected by PCR in various adult human tissues, including liver, lung, and kidney, and also in several fetal tissues.
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