ABHD1
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Official Full Name
abhydrolase domain containing 1
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Overview
This gene is a member of the AB hydrolase superfamily and encodes a protein with an alpha/beta hydrolase fold. This domain is common to a number of hydrolytic enzymes of widely differing phylogenetic origins and catalytic functions. -
Synonyms
ABHD1; abhydrolase domain containing 1; abhydrolase domain-containing protein 1; FLJ36128; LABH1; ABHD1_HUMAN; Alpha/beta hydrolase domain containing protein 1; Lung alpha/beta hydrolase 1; Lung alpha/beta hydrolase protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ABHD1 Related Articles
ABHD1 involved in several pathways and played different roles in them. We selected most pathways ABHD1 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of collagen fibrils and other multimeric structures | CTSL1;COL1A2;BMP1A;CTSB;COL1A1;COL2A1;MMP13;COL10A1;COL8A2 |
| Collagen formation | LEPRE1;COL15A1B;ADAMTS2;EMID2;LOXL1;COL4A4;PCOLCE;COL13A1;COL5A2 |
| Crosslinking of collagen fibrils | PCOLCE;TLL1;BMP1B;ABHD1;LOXL2;BMP1;LOXL1;BMP1A;LOXL4 |
| Elastic fibre formation | LTBP3;MFAP3;MFAP1B;MFAP5;LTBP2;MFAP4;FBLN2;LTBP4;LOXL3 |
| Extracellular matrix organization | PCOLCEA;MMP11;COL8A1;LTBP4;ADAMTS5;ASPN;COL5A2;MFAP1;COMP |
ABHD1 has several biochemical functions, for example, copper ion binding, protein binding, protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD1 itself. We selected most functions ABHD1 had, and list some proteins which have the same functions with ABHD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | DCT;AOC3;HIST2H3A;TYR;CCS;LOXL3;AOC2;LOXL3B;PRND |
| protein binding | WIPF1;CSNK2A2;NR2F1;MTA2;ANLN;ERN1;C9orf16;DLG1;KLF10 |
| protein-lysine 6-oxidase activity | ABHD1;LOX;LOXL2A;LOXL4;LOXL3;LOXL2;POLR1B;LOXL2B |
| scavenger receptor activity | TMPRSS13B;PRSS7;CD163L1;ENPP2;LGALS3BP;SCART1;PRSS12;VTN;PRG4B |
ABHD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD1.
CCDC155
- Q&As
- Reviews
Q&As (10)
Ask a questionIt indicated that these two genes are co-expressed in a spatial manner, however, their expression may be separated in a temporal manner.
Hirschsprung disease.
Acylglycerol lipase activity. Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
ABHD1 levels were highest in skeletal muscle, testis and liver, but over a thousand-fold lower in spleen and fibroblasts, whereas the level of expression of Sec12 was more constant between tissues and cells types, varying less than a hundred-fold.
It implied that Sec12 and ABHD1 proteins do not share any sequence homology, but it is possible that they could be functionally related.
Cellular lipid metabolic process, medium-chain fatty acid biosynthetic process, and medium-chain fatty acid catabolic process
The ABHD1 gene is existed in chimpanzee, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, etc.
By genomic sequence analysis, mapped the ABHD1 gene to chromosome 2p23.3.
20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
It indicating the crucial role of modifications induced by ABHD1 in the function of mitochondrial transfer RNA for Met (mt‐tRNAMet), and a series of other modifications occur in mt‐tRNAMet.
Customer Reviews (3)
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