ABT1
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Official Full Name
activator of basal transcription 1
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Overview
Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. -
Synonyms
activator of basal transcription 1; Basal transcriptional activator; hABT1; TATA-binding protein-binding protein; ABT1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ABT1 involved in several pathways and played different roles in them. We selected most pathways ABT1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ABT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ABT1 has several biochemical functions, for example, DNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABT1 itself. We selected most functions ABT1 had, and list some proteins which have the same functions with ABT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | RECQL;HIST1H101;POLR2J3;MEIS2A;ZNF524;RYBPA;CREM;NEUROD4;ARNTL1B |
| nucleotide binding | DHRS3;PKZ;EEF2A.1;MAT2AA;TUBA8L;RHOAE;RBM14B;UCK2B;RBM24A |
| poly(A) RNA binding | SNIP1;DNTTIP2;POLDIP3;RRP9;PTBP2;RRP36;RPS16;RPS19BP1;PUS7 |
| protein binding | TRAPPC4;NUDT21;SPRED1;COL10A1;ATRNL1;PIP5K1A;SIRT4;CXXC5;PSMC2 |
| transcription coactivator activity | EDF1;USP22;VGLL2;MED7;TADA3;ARL2BP;SUB1;RIPK3;YAF2 |
ABT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABT1.
EMD; FAM9B; SYNE4; CEP70; CDCA7L; CCDC136; LZTS2
- Q&As
- Reviews
Q&As (10)
Ask a questionABT1 protein structure contains a DNA-binding domain, an activation domain, and a dimerization domain with specific functions.
ABT1 is essential for embryonic development, and its knockout results in embryonic lethality in mice. It plays a role in the differentiation of various embryonic cell types.
ABT1 has been shown to play a crucial role in cell differentiation by regulating the expression of genes involved in this process.
ABT1 protein crystal structure is not experimentally determined yet, but computational modeling studies have predicted it based on homology to other transcription factors.
ABT1 has been shown to be involved in the development and function of the nervous system, with studies suggesting that it may play a role in synaptic plasticity and learning and memory.
ABT1 has been shown to regulate the expression of genes involved in the immune response and plays a role in the development and function of immune cells.
ABT1 knockdown or overexpression has been shown to have various effects on cellular processes, including cell proliferation, differentiation, and apoptosis.
The expression of the ABT1 gene is regulated by several factors, including transcription factors and epigenetic modifications such as DNA methylation and histone modifications.
Yes, ABT1 has been implicated in cancer development, with studies showing that its expression is dysregulated in various types of cancer.
There are currently no known mutations in the ABT1 gene that affect protein structure or function. Further studies are needed to investigate potential mutations and their effects.
Customer Reviews (3)
Write a reviewPerforms excellently in ELISA experiments.
Very stable and reliable in Western Blot experiments.
Shows outstanding performance in immunohistochemistry experiments.
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