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Recombinant Human ABT1 Protein, GST-Tagged

Cat.No. : ABT1-119H
Product Overview : Human ABT1 full-length ORF ( NP_037507.1, 1 a.a. - 272 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 57.5 kDa
AA Sequence : MEAEESEKAATEQEPLEGTEQTLDA EEEQEESEEAACGSKKRVVPGIVYL GHIPPRFRPLHVRNLLSAYGEVGRV FFQAEDRFVRRKKKAAAAAGGKKRS YTKDYTEGWVEFRDKRIAKRVAASL HNTPMGARRRSPFRYDLWNLKYLHR FTWSHLSEHLAFERQVRRQRLRAEV AQAKRETDFYLQSVERGQRFLAADG DPARPDGSWTFAQRPTEQELRARKA ARPGGRERARLATAQDKARSNKGLL ARIFGAPPPSESMEGPSLVRDS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ABT1 activator of basal transcription 1 [ Homo sapiens ]
Official Symbol : ABT1
Synonyms : hABT1
Gene ID : 29777
mRNA Refseq : NM_013375
Protein Refseq : NP_037507
UniProt ID : Q9ULW3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What is the function of the domains in the ABT1 protein structure? 07/07/2021

ABT1 protein structure contains a DNA-binding domain, an activation domain, and a dimerization domain with specific functions.

What is the effect of ABT1 on embryonic development? 01/13/2021

ABT1 is essential for embryonic development, and its knockout results in embryonic lethality in mice. It plays a role in the differentiation of various embryonic cell types.

What is the role of ABT1 in cell differentiation? 08/24/2019

ABT1 has been shown to play a crucial role in cell differentiation by regulating the expression of genes involved in this process.

What is the crystal structure of the Activator of Basal Transcription 1 (ABT1) protein? 12/10/2018

ABT1 protein crystal structure is not experimentally determined yet, but computational modeling studies have predicted it based on homology to other transcription factors.

What is the role of ABT1 in the nervous system? 08/04/2018

ABT1 has been shown to be involved in the development and function of the nervous system, with studies suggesting that it may play a role in synaptic plasticity and learning and memory.

What is the function of ABT1 in the immune system? 10/13/2016

ABT1 has been shown to regulate the expression of genes involved in the immune response and plays a role in the development and function of immune cells.

What is the effect of ABT1 knockdown or overexpression on cellular processes? 06/20/2016

ABT1 knockdown or overexpression has been shown to have various effects on cellular processes, including cell proliferation, differentiation, and apoptosis.

How is the expression of the Activator of Basal Transcription 1 (ABT1) gene regulated? 07/27/2015

The expression of the ABT1 gene is regulated by several factors, including transcription factors and epigenetic modifications such as DNA methylation and histone modifications.

Does ABT1 play a role in cancer development? 07/18/2015

Yes, ABT1 has been implicated in cancer development, with studies showing that its expression is dysregulated in various types of cancer.

Are there any known mutations in the ABT1 gene that affect protein structure or function? 04/22/2015

There are currently no known mutations in the ABT1 gene that affect protein structure or function. Further studies are needed to investigate potential mutations and their effects.

Customer Reviews (3)

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Reviews
03/09/2019

    Performs excellently in ELISA experiments.

    07/04/2017

      Very stable and reliable in Western Blot experiments.

      11/19/2016

        Shows outstanding performance in immunohistochemistry experiments.

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