ACAP1
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Official Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
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Overview
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ACAP1 gene. -
Synonyms
ACAP1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; centaurin, beta 1 , CENTB1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; KIAA0050; ANK repeat and PH domain-containing protein 1; ACAP 1; ACAP1_HUMAN; Arf GAP with coiled coil ANK repeat and PH domains 1; Arf GAP with coiled coil, ankyrin repeat, and pleckstrin homology domains 1; Arf-GAP with coiled-coil; CENT B1; Centaurin beta 1; Centaurin-beta-1; CENTB 1; Cnt b1; Cnt-b1; Cntb1; centaurin, beta 1; OTTHUMP00000128386; Arf GAP with coiled coil, ANK repeat and PH domains 1; CENTB1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Human
- Mouse
- Zebrafish
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ACAP1-0001H | Recombinant Human ACAP1 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | ACAP1-9110HCL | Recombinant Human ACAP1 293 Cell Lysate | HEK293 | N/A | ||
Human | ACAP1-2572HF | Recombinant Full Length Human ACAP1 Protein, GST-tagged | In Vitro Cell Free System | GST | 740 amino acids | |
Mouse | ACAP1-1168M | Recombinant Mouse ACAP1 Protein | Mammalian Cell | His | ||
Mouse | Acap1-1487M | Recombinant Mouse Acap1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | ACAP1-242M | Recombinant Mouse ACAP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ACAP1-242M-B | Recombinant Mouse ACAP1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Bovine | ACAP1-3614B | Recombinant Bovine ACAP1, His-tagged | E.Coli or Yeast | His | 745 | |
Zebrafish | ACAP1-5076Z | Recombinant Zebrafish ACAP1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ACAP1 involved in several pathways and played different roles in them. We selected most pathways ACAP1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocytosis | VPS37A;CLTCB;KDRL;IL2RGA;CHMP6;SRC;RAB11BA;RAB35B;SNX1 |
ACAP1 has several biochemical functions, for example, GTPase activator activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAP1 itself. We selected most functions ACAP1 had, and list some proteins which have the same functions with ACAP1. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | RGS3;STARD8;ACAP3B;RGS2;SH3BGRL3;RACGAP1;ALDH1A2;FAM13B;VPS9D1 |
metal ion binding | SP8B;ZBTB37;ABO;GUCA1E;ZBTB7B;B3GAT2;NKD2A;ZNF684;HDAC9 |
protein binding | UBASH3B;ERAP1;LAGE3;PPP2R5D;RAB9A;UBE2IB;DHX58;WAC;ZC4H2 |
ACAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAP1.
GRB2; RABGAP1L; ABL1; SRC; NCK1; IFFO1; glgX
- Q&As
- Reviews
Q&As (10)
Ask a questionRecombinant ACAP1 protein can be suitable for in vitro studies, such as biochemical assays or protein-protein interaction studies. However, it may not be suitable for in vivo studies, such as animal experiments, without appropriate modifications.
ACAP1 regulates actin cytoskeleton remodeling by interacting with Rho family GTPases, which are key regulators of the actin cytoskeleton. ACAP1 binds to the RhoA GTPase and promotes its activation, which leads to the formation of stress fibers and focal adhesions. ACAP1 also interacts with the Cdc42 GTPase and promotes the formation of filopodia and lamellipodia.
Creative BioMart offers customization options, such as the addition of tags or mutations. It is recommended to inquire with our scientist regarding customization options and the process involved. The addition of tags or mutations may affect the protein's function or analysis, and it is important to consider these factors when customizing the protein.
Recombinant ACAP1 protein is primarily used as a research tool and is not approved for diagnostic or therapeutic purposes. However, research on the function of ACAP1 may lead to the development of new diagnostic or therapeutic agents in the future.
It is often used as a positive control in Western blotting, ELISA, or other assays, or as a tool for studying the function of ACAP1.
ACAP1 has been shown to play a role in endocytic trafficking by regulating the formation of clathrin-coated vesicles. ACAP1 binds to the adaptor protein complex AP-2 and helps to recruit it to the plasma membrane. This promotes the formation of clathrin-coated vesicles, which are involved in the internalization of transmembrane receptors and other cargo molecules.
The expression system used for producing recombinant ACAP1 protein can vary depending on the specific product. Commonly used expression systems include E. coli, yeast, insect cells, and mammalian cells.
The specific buffer conditions or additives used when working with recombinant ACAN protein may depend on the specific experimental conditions and applications used. It is recommended to use buffers or media that are compatible with the protein's stability and solubility, and to avoid additives that may interfere with the protein's function or analysis. It is also important to consider the purity and endotoxin level of the protein, as these factors may affect its suitability for certain applications.
Yes, we can customize protein expression to meet your research requirements. Tagged versions can include histidine tags, GST tags, or other fusion partners that facilitate purification or detection of the protein.
Targeting ACAP1 may have potential clinical applications in cancer therapy. Inhibition of ACAP1 has been shown to reduce cancer cell migration and invasion in vitro and in vivo, suggesting that ACAP1 may be a promising target for the development of anti-cancer drugs. Additionally, ACAP1 may be a potential therapeutic target for other diseases that involve abnormal endocytic trafficking or actin cytoskeleton remodeling, such as neurodegenerative diseases and cardiovascular disorders.
Customer Reviews (3)
Write a reviewCreative BioMart's ability to customize recombinant proteins to meet my specific needs has been a game-changer for my research. I am grateful for their expertise and professionalism.
Creative BioMart's customer service is top-notch. They are always willing to go the extra mile to ensure that their customers are satisfied with their products.
I appreciate the collaboration I had with your scientists. They were able to create a custom recombinant protein that perfectly suited my needs.
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