ACOT11
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Official Full Name
acyl-CoA thioesterase 11
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Overview
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. -
Synonyms
ACOT11; acyl-CoA thioesterase 11; THEA, thioesterase, adipose associated; acyl-coenzyme A thioesterase 11; BFIT; BFIT1; KIAA0707; StAR related lipid transfer (START) domain containing 14; STARD14; THEM1; START domain containing 14; acyl-CoA thioester hyd;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | BFIT-2436H | Recombinant human BFIT, His-tagged | E.coli | His | ||
Human | ACOT11-9296H | Recombinant Human ACOT11, GST-tagged | E.coli | GST | 1-221a.a. | |
Human | ACOT11-167H | Recombinant Human ACOT11 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | ACOT11-6HCL | Recombinant Human ACOT11 lysate | HEK293 | N/A | ||
Human | ACOT11-784HF | Recombinant Full Length Human ACOT11 Protein, GST-tagged | In Vitro Cell Free System | GST | 594 amino acids |
- Involved Pathway
- Protein Function
- Interacting Protein
- ACOT11 Related Articles
ACOT11 involved in several pathways and played different roles in them. We selected most pathways ACOT11 participated on our site, such as Fatty Acyl-CoA Biosynthesis, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOT11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty Acyl-CoA Biosynthesis | ELOVL1A;ACOT6;THEM5;ACOT10;ACOT9.2;ACOT12;ACSF3;ACOT7;ACOT11B |
Fatty acid, triacylglycerol, and ketone body metabolism | ACSF3;MED16;STIL;CYP7A1;PLIN2;HELZ2;DGAT1B;MED25;MED10 |
Metabolism | CYP3A5;CYP4B1;SLC25A15;GC;FAM213B;COX5B;FAM96B;DIO2;CA13 |
Metabolism of lipids and lipoproteins | PPM1LB;GPAT2;BCHE;MED15;GRHL1;CHAT;AKR1B15;SACM1L;SACM1LA |
Triglyceride Biosynthesis | ACOT11B;ACOT10;ACOT9;ACOT12;ELOVL1A;SLC25A1;ACSF3;ACOT7;ACOT9.2 |
ACOT11 has several biochemical functions, for example, acyl-CoA hydrolase activity, carboxylic ester hydrolase activity, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOT11 itself. We selected most functions ACOT11 had, and list some proteins which have the same functions with ACOT11. You can find most of the proteins on our site.
Function | Related Protein |
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acyl-CoA hydrolase activity | ACOT11;ACOT5;ACOT10;ACSBG2;ACOT2;ACOT8;ACOT1 |
carboxylic ester hydrolase activity | AADACL4;ABHD2B;LYPLAL1;LIPI;Aadacl3;ACOT12;ACOT10;ACOT8;ACOT6 |
lipid binding | FAM123A;PITPNM3;PCYT1A;APOL3;APOA1B;RBP7B;EPN2;SEC14L4;SEC14L3 |
ACOT11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOT11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOT11.
pi3p; 2_aha_camp
- Q&As
- Reviews
Q&As (12)
Ask a questionYes, ACOT11 protein is a potential target for drug development, especially for metabolic disorders and cancer.
Yes, ACOT11 protein is a potential target for drug development in metabolic disorders, cancer research, and other areas. Targeting its activity could have therapeutic benefits for various diseases and conditions.
ACOT11 protein is not commonly used in diagnostic tests, but changes in its expression or activity may serve as biomarkers for certain diseases or conditions.
ACOT11 protein may have potential applications in the treatment of metabolic disorders such as obesity and diabetes, as well as in cancer research and sports nutrition.
ACOT11 protein is a specific type of enzyme that is involved in the breakdown of long-chain fatty acids. It has a unique structure and function compared to other enzymes involved in fatty acid metabolism, such as lipases and acyl-CoA synthetases.
ACOT11 protein may have potential anticancer effects by regulating cancer cell metabolism and inducing cell death in cancer cells.
ACOT11 protein may have therapeutic implications for the treatment of metabolic disorders such as obesity and diabetes, as well as certain types of cancer. It may also be a target for drug development to enhance fatty acid oxidation.
ACOT11 protein can help to regulate lipid metabolism and reduce lipid accumulation in tissues, which can be beneficial in preventing and treating metabolic disorders such as obesity and diabetes.
Research areas exploring the potential of ACOT11 protein include metabolic disorders such as diabetes and obesity, as well as cancer research and drug development.
ACOT11 protein is regulated by various factors, including hormones, nutrients, and metabolic pathways. Its activity can be affected by insulin, glucagon, and other hormones involved in the regulation of lipid metabolism.
One challenge is understanding the complex role of ACOT11 in lipid metabolism and its potential off-target effects on other metabolic pathways. Developing selective ACOT11 inhibitors or modulators with good pharmacokinetic properties is also a challenge.
ACOT11 protein is still being studied and has not yet been approved for specific treatments or products. However, it has been identified as a potential target for drug development in metabolic disorders and cancer research.
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