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ACOT11

  • Official Full Name

    acyl-CoA thioesterase 11

  • Overview

    This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants.
  • Synonyms

    ACOT11; acyl-CoA thioesterase 11; THEA, thioesterase, adipose associated; acyl-coenzyme A thioesterase 11; BFIT; BFIT1; KIAA0707; StAR related lipid transfer (START) domain containing 14; STARD14; THEM1; START domain containing 14; acyl-CoA thioester hyd;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BFIT-2436H Recombinant human BFIT, His-tagged E.coli His
Human ACOT11-9296H Recombinant Human ACOT11, GST-tagged E.coli GST 1-221a.a.
Human ACOT11-167H Recombinant Human ACOT11 Protein, GST-Tagged Wheat Germ GST
Human ACOT11-6HCL Recombinant Human ACOT11 lysate HEK293 N/A
Human ACOT11-784HF Recombinant Full Length Human ACOT11 Protein, GST-tagged In Vitro Cell Free System GST 594 amino acids
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACOT11 Related Articles

ACOT11 involved in several pathways and played different roles in them. We selected most pathways ACOT11 participated on our site, such as Fatty Acyl-CoA Biosynthesis, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOT11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty Acyl-CoA BiosynthesisELOVL1A;ACOT6;THEM5;ACOT10;ACOT9.2;ACOT12;ACSF3;ACOT7;ACOT11B
Fatty acid, triacylglycerol, and ketone body metabolismACSF3;MED16;STIL;CYP7A1;PLIN2;HELZ2;DGAT1B;MED25;MED10
MetabolismCYP3A5;CYP4B1;SLC25A15;GC;FAM213B;COX5B;FAM96B;DIO2;CA13
Metabolism of lipids and lipoproteinsPPM1LB;GPAT2;BCHE;MED15;GRHL1;CHAT;AKR1B15;SACM1L;SACM1LA
Triglyceride BiosynthesisACOT11B;ACOT10;ACOT9;ACOT12;ELOVL1A;SLC25A1;ACSF3;ACOT7;ACOT9.2

ACOT11 has several biochemical functions, for example, acyl-CoA hydrolase activity, carboxylic ester hydrolase activity, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOT11 itself. We selected most functions ACOT11 had, and list some proteins which have the same functions with ACOT11. You can find most of the proteins on our site.

Function Related Protein
acyl-CoA hydrolase activityACOT11;ACOT5;ACOT10;ACSBG2;ACOT2;ACOT8;ACOT1
carboxylic ester hydrolase activityAADACL4;ABHD2B;LYPLAL1;LIPI;Aadacl3;ACOT12;ACOT10;ACOT8;ACOT6
lipid bindingFAM123A;PITPNM3;PCYT1A;APOL3;APOA1B;RBP7B;EPN2;SEC14L4;SEC14L3

ACOT11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOT11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOT11.

pi3p; 2_aha_camp

Liu, XP; Yu, HY; et al. Biosynthesis of butenoic acid through fatty acid biosynthesis pathway in Escherichia coli. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 99:1795-1804(2015).
Bi, HK; Yu, YH; et al. Xanthomonas campestris RpfB is a fatty Acyl-CoA ligase required to counteract the thioesterase activity of the RpfF diffusible signal factor (DSF) synthase. MOLECULAR MICROBIOLOGY 93:262-275(2014).
  • Q&As
  • Reviews

Q&As (12)

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Can ACOT11 protein be used in drug development? 08/18/2020

Yes, ACOT11 protein is a potential target for drug development, especially for metabolic disorders and cancer.

Can ACOT11 protein be targeted for drug development? 01/27/2020

Yes, ACOT11 protein is a potential target for drug development in metabolic disorders, cancer research, and other areas. Targeting its activity could have therapeutic benefits for various diseases and conditions.

Is ACOT11 protein used in diagnostic tests? 06/07/2019

ACOT11 protein is not commonly used in diagnostic tests, but changes in its expression or activity may serve as biomarkers for certain diseases or conditions.

What are the potential applications of ACOT11 protein? 03/26/2019

ACOT11 protein may have potential applications in the treatment of metabolic disorders such as obesity and diabetes, as well as in cancer research and sports nutrition.

How is ACOT11 protein different from other fatty acid metabolism enzymes? 08/23/2018

ACOT11 protein is a specific type of enzyme that is involved in the breakdown of long-chain fatty acids. It has a unique structure and function compared to other enzymes involved in fatty acid metabolism, such as lipases and acyl-CoA synthetases.

How can ACOT11 protein be used in cancer research? 06/19/2017

ACOT11 protein may have potential anticancer effects by regulating cancer cell metabolism and inducing cell death in cancer cells.

What applications does ACOT11 protein have in medical research? 05/15/2017

ACOT11 protein may have therapeutic implications for the treatment of metabolic disorders such as obesity and diabetes, as well as certain types of cancer. It may also be a target for drug development to enhance fatty acid oxidation.

How can ACOT11 protein be used to treat metabolic disorders? 02/09/2017

ACOT11 protein can help to regulate lipid metabolism and reduce lipid accumulation in tissues, which can be beneficial in preventing and treating metabolic disorders such as obesity and diabetes.

What research areas are exploring the potential of ACOT11 protein? 01/16/2017

Research areas exploring the potential of ACOT11 protein include metabolic disorders such as diabetes and obesity, as well as cancer research and drug development.

How is ACOT11 protein regulated in the body? 01/27/2016

ACOT11 protein is regulated by various factors, including hormones, nutrients, and metabolic pathways. Its activity can be affected by insulin, glucagon, and other hormones involved in the regulation of lipid metabolism.

What challenges exist in targeting ACOT11 protein for drug development? 02/14/2015

One challenge is understanding the complex role of ACOT11 in lipid metabolism and its potential off-target effects on other metabolic pathways. Developing selective ACOT11 inhibitors or modulators with good pharmacokinetic properties is also a challenge.

Is ACOT11 protein already being used in any treatments or products? 01/31/2015

ACOT11 protein is still being studied and has not yet been approved for specific treatments or products. However, it has been identified as a potential target for drug development in metabolic disorders and cancer research.

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