ACOX2
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Official Full Name
acyl-CoA oxidase 2, branched chain -
Overview
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. -
Synonyms
ACOX2;acyl-CoA oxidase 2, branched chain;acyl Coenzyme A oxidase 2, branched chain;peroxisomal acyl-coenzyme A oxidase 2;BRCACOX;BRCOX;3 alpha 7 alpha 12 alpha trihydroxy 5 beta cholestanoyl CoA oxidase;3 alpha 7 alpha12 alpha trihydroxy 5 beta cholestanoyl CoA 24 hydroxylase;ACOX 2;Acyl Coenzyme A oxidase 2;Acyl Coenzyme A oxidase 2 branched chain;Acyl coenzyme A oxidase 2 peroxisomal;BCOX;Peroxisomal branched chain acyl CoA oxidase;THCA CoA oxidase;THCCox;Trihydroxycoprostanoyl CoA oxidase;THCA-CoA oxidase;OTTHUMP00000214196;OTTHUMP00000214197;trihydroxycoprostanoyl-CoA oxidase;acyl-Coenzyme A oxidase 2, branched chain;peroxisomal branched chain acyl-CoA oxidase;3-alpha,7-alpha,12-alpha-trihydroxy-5-bet
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- T7
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
ACOX2 involved in several pathways and played different roles in them. We selected most pathways ACOX2 participated on our site, such as Primary bile acid biosynthesis,Metabolic pathways,PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | PEX12,MPV17,AGXTB,PEX19,PRDX5,ACSL3B,PEX13,ACSL3A,NUDT7,AGPS |
| Metabolic pathways | PNLIP,UGT1A4,RDH11,UCKL1,ST6GALNAC1,NDUFC2,AGXT2L2,COX10,MOCS1,ATP5G1 |
| Primary bile acid biosynthesis | HSD17B4,CH25H,BAAT,CYP46A1.1,CH25HL2,HSD3B7,CYP46A1.2,AMACR,CYP46A1,CYP39A1 |
| PPAR signaling pathway | CYP4A10,UBC,RXRB,APOA1,ACAA1,CD36,ADIPOQB,PDPK1B,FABP6,RXRG |
Protein Function
ACOX2 has several biochemical functions, for example, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity,acyl-CoA dehydrogenase activity,acyl-CoA oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOX2 itself. We selected most functions ACOX2 had, and list some proteins which have the same functions with ACOX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acyl-CoA oxidase activity | ACOX1,ACOXL |
| fatty-acyl-CoA binding | IVD,ACADVL,ACOX1,ACBD5B,ACBD5A,ACAD9,DBIL5,GCDHB,ACAD11,ACOT7 |
| pristanoyl-CoA oxidase activity | ACOX3,ACOXL |
| electron carrier activity | ALDH4A1,TXNRD3,AIFM1,AKR7A3,GLDC,GSR,GRX2,CYCSB,GRXCR1,AKR1A1 |
| fatty acid binding | FABP10A,FABP4,FABP1B.1,NDUFAB1,PMP2,O3far1,FABP1,Alb,HNF4A,LBFABP |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ACOX1,ACADSB,IVD,ETFA,ACADVL,ACOX3,ACADL,ACAD8,GCDH,ACOXL |
| acyl-CoA dehydrogenase activity | ACADM,ACADSB,ACADL,ACOXL,ACAD8,ACOX1,ETFA,ACAD9,GCDHA,ACOX3 |
| flavin adenine dinucleotide binding | NOX5,MAOA,NOS3,TXNRD2,NOX4,AOX3,KDM1B,GULO,XDH,AOX1 |
| receptor binding | JAK2,CAV1,NPPB,PTPRD,TRIM24,PIPOX,CX3CL1,PTK6,VTCN1,CRTAM |
Interacting Protein
ACOX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOX2.
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