ACTN2

  • Official Full Name

    actinin, alpha 2
  • Overview

    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
  • Synonyms

    ACTN2;actinin, alpha 2;CMD1AA;alpha-actinin-2;F-actin cross-linking protein;alpha-actinin skeletal muscle

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • MBP
  • DDK
  • Myc
  • GST
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACTN2-31382TH Recombinant Human ACTN2, His-tagged E.coli Human His 261-886 a.a.
ACTN2-361H Recombinant Human ACTN2 protein, His/MBP-tagged E.coli Human His&MBP 1-205 aa
Actn2-539M Recombinant Mouse Actn2 Protein, His-tagged E.coli Mouse His Met1~His254
ACTN2-6875C Recombinant Chicken ACTN2 Mammalian Cells Chicken His
ACTN2-1023H Recombinant Human ACTN2 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
ACTN2-1622H Recombinant Human ACTN2 protein, GST-tagged E.coli Human GST 1-301 aa
ACTN2-271H Recombinant Human ACTN2 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ACTN2-271H-B Recombinant Human ACTN2 Protein Pre-coupled Magnetic Beads HEK293 Human
Actn2-526M Recombinant Mouse Actn2 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
ACTN2-5633H Recombinant Human ACTN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
ACTN2-968HFL Recombinant Full Length Human ACTN2 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    ACTN2 involved in several pathways and played different roles in them. We selected most pathways ACTN2 participated on our site, such as Focal adhesion,Adherens junction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Systemic lupus erythematosus SSB,GM14478,HIST1H4G,TROVE2,FCGR1A,HIST1H2AC,HIST1H2AN,HIST1H4K,C5,HLA-DMB
    Regulation of Actin Cytoskeleton PAK2,MYL12.2,ACTB,DIAP3,MSN,PIP5K1AB,LIMK1A,PIK3R3B,FGF2,BRK1
    Tight junction ZAK,PRKCH,MAGI3,EPB41L3A,ACTN4,RHOAA,PRKCD,MYH13,MAGI1B,CLDN14
    Amoebiasis LAMA2,PIK3R2,LAMB4,GNA15,IL1B,PIK3CG,PLCB4,SERPINB1B,ACTN1,PRKACA
    Focal adhesion CCND2,FN1,SHC4,PGF,PARVAA,RAP1B,ACTG1,RHOAC,TNXB,LAMB2
    Adherens junction PARD3,TJP1,CDC42,ACTB,YES1,EGFRA,CTNNA3,IGF1RB,SSX2IP,CTNNB1
    Leukocyte transendothelial migration NOX1,CLDN4,PIK3CB,ITGAL,VAV3,ITGB2,MAPK11,PRKCA,VCL,CLDN5
    Viral carcinogenesis HDAC7,IRF3,TRADD,BAD,NFKB1,HIST1H2BO,C3,VAC14,HIST1H2BC,STAT5A
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ACTN3,ITGA1,CACNG2,EMD,CACNB4,ACTN4,AASS,DMD,CACNB3,ITGB8

    Protein Function

    ACTN2 has several biochemical functions, for example, FATZ binding,LIM domain binding,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN2 itself. We selected most functions ACTN2 had, and list some proteins which have the same functions with ACTN2. You can find most of the proteins on our site.

    Function Related Protein
    cytoskeletal protein binding EPB41L4A,EPB41L3B,ALDOA,FABP3,PACSIN1,NEBL,PTPN4A,CAPN2,TPM1,EPB41B
    integrin binding ANXA7,WISP1A,SEMA7A,CTGFA,Npnt,TGFBI,Tcam1,ITGB5,ESM1,EDIL3
    structural constituent of muscle COX4I2,TPM1,SYNM,CSRP3,ANKRD2,MYL9,MYL3,MYL6,PLEC,NEBL
    identical protein binding RNF4,DIAPH1,CLDN14,ALAD,KHDRBS1,COMMD1,TRIM23,ATL1,ECI1,NONO
    protein binding SCG5,PNMA1,PAEP,ZCCHC12,PSME3,HMG20A,G0S2,ATF7IP,SERPINC1,PGF
    phosphatidylinositol-4,5-bisphosphate binding FAM123B,SNX20,TULP1,KCNQ1,TWF1,SYTL2,TIRAP,ASAP1,ALOX15,SNX18
    protein homodimerization activity ANO6,CADM1A,PLD6,GHR,IGJ,HELT,TPD52L1,ZFP423,CR2,CTBP2A
    FATZ binding TCAP,MYOZ1
    protein domain specific binding NF2,SERPINB1A,CBX3,YWHABL,CALM,POU2F2,NCK1,HIST4H4,HIST1H4K,HIST1H4A

    Interacting Protein

    ACTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN2.

    TTN

    Resources

    References

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