ACTN2

  • Official Full Name

    actinin, alpha 2
  • Overview

    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
  • Synonyms

    ACTN2;actinin, alpha 2;CMD1AA;alpha-actinin-2;F-actin cross-linking protein;alpha-actinin skeletal muscle

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • MBP
  • DDK
  • Myc
  • GST
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACTN2-31382TH Recombinant Human ACTN2, His-tagged E.coli Human His 261-886 a.a.
ACTN2-361H Recombinant Human ACTN2 protein, His/MBP-tagged E.coli Human His&MBP 1-205 aa
Actn2-539M Recombinant Mouse Actn2 Protein, His-tagged E.coli Mouse His Met1~His254
ACTN2-6875C Recombinant Chicken ACTN2 Mammalian Cells Chicken His
ACTN2-1023H Recombinant Human ACTN2 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
ACTN2-1622H Recombinant Human ACTN2 protein, GST-tagged E.coli Human GST 1-301 aa
ACTN2-271H Recombinant Human ACTN2 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ACTN2-271H-B Recombinant Human ACTN2 Protein Pre-coupled Magnetic Beads HEK293 Human
Actn2-526M Recombinant Mouse Actn2 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
ACTN2-5633H Recombinant Human ACTN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
ACTN2-968HFL Recombinant Full Length Human ACTN2 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    ACTN2 involved in several pathways and played different roles in them. We selected most pathways ACTN2 participated on our site, such as Focal adhesion,Adherens junction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) SGCD,ITGB4,AASS,CACNG7,ITGB5,ACTG1,CACNA2D4,PKP2,SGCG,ITGA5
    Adherens junction PVRL3,SNAI2,IGF1RA,TJP1,MET,CTNNA3,PVRL3B,FYNA,FER,WASLB
    Tight junction PPP2R2C,AKT2L,CTTN,CLDNJ,CLDN19,EPB41L3,YES1,GNAI1,EPB41L1,MYH13
    Amoebiasis SERPINB3C,PRKACA,CD14,COL4A5,TLR4,PIK3R2,PRKACB,PRKCB,TGFB2,COL4A4
    Focal adhesion AKT1,MAPK3,TLN2A,PTEN,TNXB,FIGF,PDPK1,IGF1RA,PAK1,PAK2A
    Regulation of Actin Cytoskeleton FGFR2,ITGB2L,DIAP1,MYL2B,GIT1,INSB,FGF14,FGF20B,DIAP3,MYL5
    Viral carcinogenesis MAD1L1,MRPS18B,HDAC8,PMAIP1,BAX,TRAF1,HIST1H4F,GTF2A1,HIST1H4K,PRKACB
    Systemic lupus erythematosus HIST3H2A,HLA-DMA,HIST1H3H,GM14479,HIST1H4B,C6,HIST1H2BM,HIST1H2BC,H3F3B,HIST1H2BF
    Leukocyte transendothelial migration PIK3CB,NCF4,MMP9,ACTN1,BCAR1,F11R,PTK2B,ACTN4,VAV2,VAV1

    Protein Function

    ACTN2 has several biochemical functions, for example, FATZ binding,LIM domain binding,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN2 itself. We selected most functions ACTN2 had, and list some proteins which have the same functions with ACTN2. You can find most of the proteins on our site.

    Function Related Protein
    titin Z domain binding TCAP
    protein dimerization activity TFAP2A,PEF1,DAO1,AHRRB,MGAA,HER1,HES4,ASCL2,FAP,ID2
    FATZ binding TCAP,MYOZ1
    thyroid hormone receptor coactivator activity NCOA2,MED16,MED1
    protein binding GAPDH,EPB41L3,PFKFB1,DNAI2,RAD9,ANKZF1,RTF1,MITD1,SLC41A3,SCARA5
    integrin binding ILK,KDR,COL16A1,ADAM9,LAMB1,CYR61L1,LAMA5,ECM2,SRC,FBN1
    cytoskeletal protein binding FARP1,EPB41L3B,ALDOA,NF2A,FRMD3,MYLIP,ALDOB,PDLIM3,EPB41L5,FARP2
    actin filament binding TTN,EGFR,VIL1,SYNE1,PLDN,TAGLN3A,TRIOBPB,CORO1A,ADSSL1,FSCN1A
    protein homodimerization activity GRHPR,ADH5,GPD1L,P2RX7,AP1S2,GPD1,SUMF1,AIMP1,PRKG2,EXT1

    Interacting Protein

    ACTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN2.

    TTN

    Resources

    References

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