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ACTN2

Official Full Name

actinin, alpha 2
Overview

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Synonyms

ACTN2; actinin, alpha 2; CMD1AA; alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
His|MBP
Myc
DDK
MYC
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ACTN2-31382TH	Recombinant Human ACTN2, His-tagged	E.coli	His		Inquiry
Human	ACTN2-361H	Recombinant Human ACTN2 protein, His/MBP-tagged	E.coli	His/MBP	1-205 aa	Inquiry
Human	ACTN2-968HFL	Recombinant Full Length Human ACTN2 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	ACTN2-5633H	Recombinant Human ACTN2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	ACTN2-1023H	Recombinant Human ACTN2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	ACTN2-271H	Recombinant Human ACTN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	ACTN2-271H-B	Recombinant Human ACTN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Actn2-539M	Recombinant Mouse Actn2 Protein, His-tagged	E.coli	His	Met1~His254	Inquiry
Mouse	Actn2-526M	Recombinant Mouse Actn2 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Chicken	ACTN2-6875C	Recombinant Chicken ACTN2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ACTN2 Related Research Area

ACTN2 involved in several pathways and played different roles in them. We selected most pathways ACTN2 participated on our site, such as Focal adhesion, Adherens junction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Focal adhesion	CAV3;PPP1CB;VCLA;PPP1CAB;HGF;IGF1;COL6A6;RHOAD;VASPA
Adherens junction	PTPRFB;TCF7L2;RHOAA;SNAI2;SNAI1;WASLB;WASB;CSNK2B;EGFR
Tight junction	MPP5A;CLDNB;PPP2R1B;OCLNB;MYH1;TJP2A;CLDN1;PTENA;RRAS
Leukocyte transendothelial migration	PLCG1;MAPK12;PRKCA;NIPAL1;Itgam&Itgb2;ITGB1;ITGB2;PIK3CD;CDH5
Regulation of actin cytoskeleton	VCL;F2R;MAP2K2A;FGF13;SCINLB;FGFR4;FGD1;ITGB4;ACTB2
Amoebiasis	LAMA4;IL-8;GNA15;PIK3R5;PIK3R2;LAMC1;FN1;ACTN4;TGFB2
Viral carcinogenesis	PKM2;C3;TBPL1;RELA;CCNE1;HRAS;DNAJA3;PIK3R5;ACTN3
Systemic lupus erythematosus	HIST1H2AP;ELANE;IFNG;HIST1H2BF;CD86;HIST1H2AB;GM14476;H2AFB1;C8B
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	LAMA2;ITGA2;CACNG6;EMD;TCF7L2;PKP2;CACNG1;ITGA8;DES

ACTN2 has several biochemical functions, for example, FATZ binding, LIM domain binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN2 itself. We selected most functions ACTN2 had, and list some proteins which have the same functions with ACTN2. You can find most of the proteins on our site.

Function	Related Protein
FATZ binding	TCAP;ACTN2;MYOZ1
LIM domain binding	RPH3AL;LDB2A;ACTN2;RIPK2;CSRP2BP;LDB1A;LDB1B;TLN1;LDB2
actin filament binding	MYO18A;MYO10;WIPF3;CORO1A;SYNE1;FMNL1;FSCN1A;MYO1A;PICK1
calcium ion binding	MYL2;CAPSLB;PLCB3;LTBP2;CAPN2L;COMP;ANXA9;PVALB5;ANXA6
cytoskeletal protein binding	PACSIN1A;ALDOC;FLNC;FARP2;PKD2L1;FRMD5;ALDOB;SLC8A1;MYLIP
identical protein binding	TOPBP1;ALDH4A1;SERPINA1A;JMJD6;FUS;AIRE;TK1;RELA;PITX2
integrin binding	CALR;JAM3;ECM2;FN1A;ADAM23;LAMB1;ACTN2;FERMT3;ACTN4
ion channel binding	AP2M1;FGF12;TCAP;ACTN2;SNTA1;KCNIP2;LRRK2;DIAPH1;FYN
phosphatidylinositol-4,5-bisphosphate binding	ANXA2;ALOX15;MYO1G;EXOC1;PFN1;FCHO2;PHLDA3;TIRAP;SYTL2
protein binding	PPP4R2;RABGAP1;TEX11;CCDC28B;ZNF131;VTI1B;SMIM3;UNC13A;CEP85
protein dimerization activity	TFAP2B;FBXW11B;HER4.3;ZBED6;EBF1;MXD1;SMG1;TCF3B;ANO7
protein domain specific binding	YWHAQA;HAND2;IST1;MED12;MYO7A;MECP2;HIST1H4N;CALM1;LIN7B
protein homodimerization activity	MYH7;SNF8;LRRC41;LGALS1;DGCR8;CHMP4C;LHPP;ABCB10;CORO1A
structural constituent of muscle	MYLPF;MYBPH;MYOT;MYOM1;MYL5;MYL6B;MYL2;MYL9;CAPN3
thyroid hormone receptor coactivator activity	NCOA2;ACTN2;MED1;MED16
titin Z domain binding	TCAP;ACTN2
titin binding	SLC14A2;TRIM63;OBSCN;TCAP;CALM;CAMK2D;ANKRD2;ANKRD1B;ANKRD23

ACTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN2.

TTN

Actin Cytoskeleton and Stress Fiber Molecules