actn2

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actn2

Official Full Name actinin, alpha 2
Background Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Synonyms ACTN2; actinin, alpha 2; CMD1AA; alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • MBP
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ACTN2-1023H Recombinant Human ACTN2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ACTN2-31382TH Recombinant Human ACTN2, His-tagged E.coli His
    Human ACTN2-361H Recombinant Human ACTN2 protein, His/MBP-tagged E.coli His/MBP
    Mouse Actn2-539M Recombinant Mouse Actn2 Protein, His-tagged E.coli His
    Chicken ACTN2-6875C Recombinant Chicken ACTN2 Mammalian Cell His

    actn2 involved in several pathways and played different roles in them. We selected most pathways actn2 participated on our site, such as Focal adhesion, Adherens junction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with actn2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Focal adhesion CCND1; VAV3B; SHC1; STYK1; IGF1; ITGA3; PAK1; TESK2; COL27A1B; PIP5K1C
    Adherens junction PTPN6; EGFRA; WASF3; NLK; TCF7L1A; VCL; INSR; MAPK3; PVRL4; ACTN1
    Tight junction TJP1; PPP2R1A; MYH10; EXOC4; ACTG1; PRKCDA; CLDND; MRAS; CLDN11B; MYLPFA
    Leukocyte transendothelial migration RAP1B; PIK3R1; MAPK12; CLDN20; VAV2; TXK; CYBB; ICAM1; ITGAL; BCAR1
    Regulation of actin cytoskeleton ACTN3B; BRAF; RHOAB; CFL2L; MYL12.1; FGF8A; PFN3; ARHGEF6; MYLK; INS2
    Amoebiasis PIK3R5; COL4A6; COL3A1; CD14; C8B; IL1R1; TGFB2; C9; TLR4; PRKACG
    Viral carcinogenesis CDC42; HDAC11; HIST1H2BQ; UBR4; KRAS; TRAF3; SND1; PIK3R2; ACTN1; MAD1L1
    Systemic lupus erythematosus H3F3B; CD40LG; SNRPD1; SSB; H2AFB1; GM14482; HLA-DRB3; CD40; H2AFB3; C6
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) LMNA; CTNNA3; ACTB; EMD; ATP2A2; CACNA2D2; ACTN2; CACNG7; ITGB7; DSG2

    actn2 has several biochemical functions, for example, FATZ binding, LIM domain binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by actn2 itself. We selected most functions actn2 had, and list some proteins which have the same functions with actn2. You can find most of the proteins on our site.

    Function Related Protein
    FATZ binding MYOZ1; ACTN2; TCAP
    LIM domain binding ACTN2; LDB2; RPH3AL; LDB1; LDB2A; RIPK2; CSRP2BP; LDB2B; TLN1; LDB1A
    actin filament binding TTN; PPP1R9A; EZR; WIPF2; WIPF1A; CTNNAL1; ADD2; PLDN; WIPF2B; TNNC1
    calcium ion binding FKBP9; ESYT2; PCDH10B; MGP; LCP1; SYT11A; SYTL1; CABP7; JAG1B; ICN2
    cytoskeletal protein binding EZRA; RPH3AL; MYLIP; FABP3; PTPN4A; CORO1A; ALDOB; EPB41B; MSNA; EPB41L4A
    identical protein binding S100B; TPRG1L; RASSF3; ATXN10; SLC22A1; TTN; C10orf88; CALHM1; MUL1; CLDN23
    integrin binding Tcam1; ITGB1; COL3A1; WISP1; FN1; THY1; GPNMB; TSPAN8; GFAP; TGFBI
    ion channel binding KCNIP1; SNTA1; CALM; PACS2; AKAP9; FYN; ACTN1; ACTN4; NOS1; RNF207
    phosphatidylinositol-4,5-bisphosphate binding VIL1; RPH3A; SYT1; TULP1; KCNQ1; D6WSU116E; ANXA8; RAG2; AMER2; RS1
    protein binding USH1G; KCNJ9; SPI1B; CD6; FAM13C; CSNK1G2; C2orf62; EGLN1; MAP1B; INHA
    protein dimerization activity MYCA; SOHLH2; HIF1AB; TWIST1B; ASCL4; TCF3B; FIGLA; NHLH1; ATOH1B; ID2B
    protein domain specific binding NFASC; MRPS31; ZBTB16; ARFIP2B; TWIST2; MTOR; CASKIN1; PRKCZ; XPO1; HIST1H4K
    protein homodimerization activity ASCL1; SLC30A8; PVR; ADH1; SEPHS1; USF1; FAM109B; ABAT; PRKG2; RRAGA
    structural constituent of muscle MYLPF; TPM1; TPM2; MYBPC3; DMD; MYOT; MYL5; SORBS2; TTN; MYBPC2
    thyroid hormone receptor coactivator activity NCOA2; MED1; MED16; ACTN2
    titin Z domain binding ACTN2; TCAP
    titin binding ANKRD1B; CAPN3; TRIM63; ANKRD1; TCAP; ACTN2; CALM1; CALM2; MYBPC3; OBSCN

    actn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with actn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of actn2.

    TTN

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