ACTN3
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Official Full Name
actinin, alpha 3 -
Overview
This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed;in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in;crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and;non-coding variants. The reference genome contains the non-coding allele. The non-functional allele of this gene is;associated with elite athlete status.
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ACTN3-9343H | Recombinant Human ACTN3 protein, His/T7-tagged | E.coli | Human | His&T7 | Glu162ca.Lys416 | |
| ACTN3-9341H | Recombinant Human ACTN3 protein, GST-tagged | E.coli | Human | GST | 577-624 aa | |
| Actn3-3335M | Recombinant Mouse Actn3, His-tagged | E.Coli/Yeast | Mouse | His | 900 |
|
| ACTN3-9342H | Recombinant Human ACTN3 protein | E.coli | Human | Non | 325 to 608 |
|
| ACTN3-3280C | Native Chicken ACTN3 | Chicken Gizzard | Chicken | Non |
|
Involved Pathway
ACTN3 involved in several pathways and played different roles in them. We selected most pathways ACTN3 participated on our site, such as Focal adhesion,Adherens junction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tight junction | PPP2CA,LLGL2,CLDN6,MYH7,PPP2R2C,VMHC,CLDNK,CTTN,MYHZ1.1,MYL9B |
| Leukocyte transendothelial migration | Itgam&Itgb2,ARHGAP35,ESAM,NIPAL1,CLDN3,ITGB2,MYLPF,TXK,CLDN1,NCF2 |
| Systemic lupus erythematosus | HIST1H3F,HIST1H2AH,HLA-DRA,HIST1H2BC,H2AFJ,GM5077,ACTN2,TRIM21,HIST1H4L,HIST2H2BB |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ATP2A2,ITGA2,RYR2,ACTN4,ITGA3,CACNG6,CDH2,TCF7,ITGA2B,CACNA2D2 |
| Regulation of Actin Cytoskeleton | PIP5K1A,PIP4K2B,SRC,MSN,INSB,PIP4K2C,MYL9A,FGF21,FGFR3,PAK2B |
| Focal adhesion | RHOAB,ITGA10,MYLK4,RAF1,MYLPFA,PIK3R3A,PDGFA,ITGA4,PGF,RAC3A |
| Adherens junction | ERBB2,TGFBR2,IGF1R,SNAI1,PTBP3,SRC,SMAD4,RAC1B,PTPN1,PTPRJA |
| Viral carcinogenesis | RBL2,ATP6V0D2,SCIN,RBPJL,HIST1H4D,HIST1H2BP,HIST1H2BG,HIST1H2BO,HIST1H4J,HLA-A |
| Amoebiasis | COL4A6,PLCB2,PTK2,LAMC2,LAMA1,CXCL8,COL1A1,IL12B,RAB7,RAB5C |
Protein Function
ACTN3 has several biochemical functions, for example, actin binding,calcium ion binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN3 itself. We selected most functions ACTN3 had, and list some proteins which have the same functions with ACTN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IGFBP5,DEDD2,TESC,CCDC50,EIF4EBP2,BIRC3,ZKSCAN17,CCDC47,DNAJB1,MUTED |
| structural constituent of muscle | ANKRD2,TPM2,MYL6,MYBPC1,PLEC,DMD,MYL5,NEBL,MYLPF,MYBPC2 |
| protein homodimerization activity | PDCD10,INHBB,MTERFD3,TIMM10,CBX5,S100B,RPE,CIB2,VOX,BCL11A |
| calcium ion binding | FBLN7,DGKB,GM5077,PCDH1,DSC2,DSG2,NDUFAB1,KCNIP3A,PCDH2G29,PCDHB10 |
| ion channel binding | PDE4B,SRC,CIB1,PANX1,DIAP1,RNF207,ARRB1,PHPT1,TRAPPC2,HSP90AB1 |
| integrin binding | VTN,MMP14,ANXA7,ACTN2,CTGFB,FBLN1,ITGB6,ADAM9,CYR61,ADAM2 |
| actin binding | FHL3,EPS8L1,TMSB,STK38L,KLHL20,MYH10,MICAL2B,GMFB,KLHL3,NRAP |
Interacting Protein
ACTN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN3.
FBP1;TTN;15-deoxy-delta(12,14;YWHAZ;ESR2
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