ACTN3

  • Official Full Name

    actinin, alpha 3
  • Overview

    This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed;in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in;crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and;non-coding variants. The reference genome contains the non-coding allele. The non-functional allele of this gene is;associated with elite athlete status.
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACTN3-9343H Recombinant Human ACTN3 protein, His/T7-tagged E.coli Human His&T7 Glu162ca.Lys416
ACTN3-9341H Recombinant Human ACTN3 protein, GST-tagged E.coli Human GST 577-624 aa
Actn3-3335M Recombinant Mouse Actn3, His-tagged E.Coli/Yeast Mouse His 900
ACTN3-9342H Recombinant Human ACTN3 protein E.coli Human Non 325 to 608
ACTN3-3280C Native Chicken ACTN3 Chicken Gizzard Chicken Non

    Involved Pathway

    ACTN3 involved in several pathways and played different roles in them. We selected most pathways ACTN3 participated on our site, such as Focal adhesion,Adherens junction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Tight junction PPP2CA,LLGL2,CLDN6,MYH7,PPP2R2C,VMHC,CLDNK,CTTN,MYHZ1.1,MYL9B
    Leukocyte transendothelial migration Itgam&Itgb2,ARHGAP35,ESAM,NIPAL1,CLDN3,ITGB2,MYLPF,TXK,CLDN1,NCF2
    Systemic lupus erythematosus HIST1H3F,HIST1H2AH,HLA-DRA,HIST1H2BC,H2AFJ,GM5077,ACTN2,TRIM21,HIST1H4L,HIST2H2BB
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ATP2A2,ITGA2,RYR2,ACTN4,ITGA3,CACNG6,CDH2,TCF7,ITGA2B,CACNA2D2
    Regulation of Actin Cytoskeleton PIP5K1A,PIP4K2B,SRC,MSN,INSB,PIP4K2C,MYL9A,FGF21,FGFR3,PAK2B
    Focal adhesion RHOAB,ITGA10,MYLK4,RAF1,MYLPFA,PIK3R3A,PDGFA,ITGA4,PGF,RAC3A
    Adherens junction ERBB2,TGFBR2,IGF1R,SNAI1,PTBP3,SRC,SMAD4,RAC1B,PTPN1,PTPRJA
    Viral carcinogenesis RBL2,ATP6V0D2,SCIN,RBPJL,HIST1H4D,HIST1H2BP,HIST1H2BG,HIST1H2BO,HIST1H4J,HLA-A
    Amoebiasis COL4A6,PLCB2,PTK2,LAMC2,LAMA1,CXCL8,COL1A1,IL12B,RAB7,RAB5C

    Protein Function

    ACTN3 has several biochemical functions, for example, actin binding,calcium ion binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN3 itself. We selected most functions ACTN3 had, and list some proteins which have the same functions with ACTN3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding IGFBP5,DEDD2,TESC,CCDC50,EIF4EBP2,BIRC3,ZKSCAN17,CCDC47,DNAJB1,MUTED
    structural constituent of muscle ANKRD2,TPM2,MYL6,MYBPC1,PLEC,DMD,MYL5,NEBL,MYLPF,MYBPC2
    protein homodimerization activity PDCD10,INHBB,MTERFD3,TIMM10,CBX5,S100B,RPE,CIB2,VOX,BCL11A
    calcium ion binding FBLN7,DGKB,GM5077,PCDH1,DSC2,DSG2,NDUFAB1,KCNIP3A,PCDH2G29,PCDHB10
    ion channel binding PDE4B,SRC,CIB1,PANX1,DIAP1,RNF207,ARRB1,PHPT1,TRAPPC2,HSP90AB1
    integrin binding VTN,MMP14,ANXA7,ACTN2,CTGFB,FBLN1,ITGB6,ADAM9,CYR61,ADAM2
    actin binding FHL3,EPS8L1,TMSB,STK38L,KLHL20,MYH10,MICAL2B,GMFB,KLHL3,NRAP

    Interacting Protein

    ACTN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN3.

    FBP1;TTN;15-deoxy-delta(12,14;YWHAZ;ESR2

    Resources

    References

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