Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ADH1

  • Official Full Name

    Adh1p

  • Overview

    Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene.
  • Synonyms

    ADH1; Adh1p; ADC1; ADH alpha subunit; ADH; ADH1A; Alcohol dehydrogenase 1; Aldehyde reductase; YADH 1; EC 1.1.1.1EC 1.1.1.190Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Entamoeba Histolytica
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|T7
  • MYC
  • DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse Adh1-778M Recombinant Mouse Adh1 protein, His & T7-tagged E.coli His/T7 Glu25~Asp228 (Accession # P00329)
Mouse ADH1-1353M Recombinant Mouse ADH1 Protein Mammalian Cell His
Mouse Adh1-541M Recombinant Mouse Adh1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ADH1-342M-B Recombinant Mouse ADH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ADH1-342M Recombinant Mouse ADH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Entamoeba Histolytica ADH1-156 Active Recombinant Entamoeba histolytica ADH1 protein, His-tagged E.coli His 360 amino acids
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADH1 Related Articles

ADH1 involved in several pathways and played different roles in them. We selected most pathways ADH1 participated on our site, such as Glycolysis / Gluconeogenesis, Fatty acid degradation, Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisENO3;PDHA1B;AKR1A1;PCK2;HK3;ALDOCB;ADH6;ALDH9A1B;GPI
Fatty acid degradationACADS;ALDH9A1B;ACAT1;ALDH2.1;ALDH1B1;ALDH9A1;ADH1C;HADHAB;HADHB
Tyrosine metabolismGOT2B;COMTB;MIF;COMTA;FAHD1;TYRP1;TH;AOX2P;GOT2
Retinol metabolismCYP3A41A;UGT1A6A;ALDH1A2;UGT1A6B;RDH8A;SDR16C5;UGT1A7;DHRS4;UGT1A3
Metabolism of xenobiotics by cytochrome PUGT1A6A;UGT1A1;CYP1A;GSTA1;UGT1A3;GSTM6;SULT2A1;UGT1A7C;DHDHL
Drug metabolism - cytochrome PMGST1.1;MGST1;FMO3;UGT2B7;ADH1;FMO4;GSTM7;ALDH3B1;FMO6P
Metabolic pathwaysGLUD1A;MPI;Atp5g2;Atp5k;ATP5F1;DCXR;PAH;DEGS2;NMNAT3
Chemical carcinogenesisCYP2B19;GSTA2;GSTO2;CYP2C54;UGT1A6B;ADH1;GSTM3;UGT2B7;GSTP2

ADH1 has several biochemical functions, for example, NAD binding, alcohol dehydrogenase (NAD) activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH1 itself. We selected most functions ADH1 had, and list some proteins which have the same functions with ADH1. You can find most of the proteins on our site.

Function Related Protein
NAD bindingCTBP2A;NDUFV1;GPD1A;IDH2;CTBP1;GRHPRB;HSD3B5;HIBADHA;HPGD
alcohol dehydrogenase (NAD) activityADH5;ADH8A;ADH7;ADH1C;ADH1A;ADH8B;DHRS9;ADH6;ADH1
drug bindingFSCN1;DHFR;HMGCS1;CHRNA7;PYGM;PDE4C;GABRA1;PNP;SLC6A4A
ethanol bindingADH7;PRKCE;ADH1;ADH4
metal ion bindingRASA3;CYB5R4;GFI1B;PDSS1;NCALDB;MORC2A;NPTXR;RHEBL1;PITPNM1
oxidoreductase activityAKR1B8;RDH14A;Akr1b3;LOXL2A;DHRS7CB;SDR42E1;SCCPDHB;PYROXD2;HSD17B6
protein homodimerization activityCRYM;FLT3LG;PDGFA;QPRT;MYH9;GNPTG;KLHL7;STUB1;MAPK4
retinol dehydrogenase activityDHRS3;RDH1;RDH10;RDH12;RDH11;DHRS7C;ADH7;BMP2;AKR1C3
zinc ion bindingMT1F;PARK2;WT1;TRIM67;TRIM27;ING1;SRSF7A;XRN2;PDLIM5

ADH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH1.

Ywhae; Ywhaz; Pgls; Hsd3b7

Ardizzoni, A; Posteraro, B; et al. AN ANTIBODY REACTIVITY-BASED ASSAY FOR DIAGNOSIS OF INVASIVE CANDIDIASIS USING PROTEIN ARRAY. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 27:403-412(2014).
Chiang, CP; Wu, CW; et al. Expression Pattern, Ethanol-Metabolizing Activities, and Cellular Localization of Alcohol and Aldehyde Dehydrogenases in Human Small Intestine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:2047-2058(2012).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How does Adh1 contribute to alcohol metabolism, and what is its catalytic efficiency and substrate specificity compared to other ADH isoforms? 06/13/2022

Adh1 plays a significant role in alcohol metabolism, showing specific catalytic efficiency and substrate specificity for the conversion of alcohol to acetaldehyde.

How does the expression or activity of Adh1 change in response to pharmacological agents or environmental factors, and what are the implications for alcohol metabolism or therapy? 08/21/2021

Pharmacological agents or environmental factors can modulate Adh1 expression or activity, potentially influencing alcohol metabolism and providing avenues for therapeutic interventions or personalized medicine.

What are the regulatory mechanisms controlling Adh1 expression, and how do they respond to alcohol exposure or other metabolic factors? 07/30/2020

The expression of Adh1 is regulated by specific mechanisms, including transcriptional and post-transcriptional regulation, which can respond to alcohol exposure or metabolic factors such as hormonal signaling.

Are there any cofactors or coenzymes required for Adh1 activity, and how do they influence its catalytic function? 07/31/2019

Adh1 requires specific cofactors or coenzymes, such as NAD+ or NADH, for its activity, serving as electron carriers and modulators of Adh1 function.

What are the consequences of Adh1 deficiency or knockout in experimental models, and how does it affect alcohol metabolism and related phenotypes? 01/16/2019

Adh1 deficiency or knockout in experimental models leads to altered alcohol metabolism and related phenotypes, such as decreased alcohol clearance and increased sensitivity to alcohol-induced effects.

How does Adh1 expression or activity vary in different species or populations, and what are the underlying genetic and environmental factors influencing these variations? 12/29/2018

Adh1 expression or activity may vary among different species or populations, influenced by genetic and environmental factors, contributing to inter-individual or inter-species differences in alcohol metabolism and tolerance.

What are the structural features of Adh1, and how do they relate to its enzymatic activity and substrate binding? 12/27/2018

The structural features of Adh1, such as its active site and binding domains, are critical for its enzymatic activity and substrate recognition, enabling efficient alcohol oxidation.

Can Adh1 metabolize other substrates apart from alcohol, and what are the implications for its broader metabolic role? 04/23/2018

Adh1 has the capacity to metabolize other substrates beyond alcohol, suggesting its involvement in broader metabolic pathways and potential metabolic interactions.

Are there any genetic variations or polymorphisms in the Adh1 gene associated with differences in alcohol metabolism or susceptibility to alcohol-related disorders? 07/23/2017

Genetic variations or polymorphisms in the Adh1 gene have been associated with differences in alcohol metabolism and susceptibility to alcohol-related disorders, highlighting the impact of genotype on phenotype.

What is the tissue-specific expression pattern of Adh1, and how does it differ from other ADH isoforms in terms of its expression levels and distribution across organs and cell types? 12/19/2016

Adh1 exhibits a tissue-specific expression pattern, with higher expression levels in certain organs such as the liver, and its distribution may differ from other ADH isoforms, reflecting functional specialization.

Customer Reviews (2)

Write a review
Reviews
09/26/2021

    Highly effective in blocking protein-protein interactions in competition assays.

    11/14/2018

      Shows excellent target engagement and modulation in drug discovery studies.

      Ask a Question for All ADH1 Products

      Required fields are marked with *

      My Review for All ADH1 Products

      Required fields are marked with *

      logo

      FOLLOW US

      Terms and Conditions        Privacy Policy

      Copyright © 2024 Creative BioMart. All Rights Reserved.

      Contact Us

      • /

      Stay Updated on the Latest Bioscience Trends