ADH1
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Official Full Name
Adh1p -
Overview
Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene. -
Synonyms
ADH1;Adh1p;ADC1;ADH alpha subunit;ADH;ADH1A;Alcohol dehydrogenase 1;Aldehyde reductase;YADH 1;EC 1.1.1.1EC 1.1.1.190Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers;required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADH1-156 |
Active Recombinant Entamoeba histolytica ADH1 protein, His-tagged
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E.coli | Entamoeba Histolytica | His | 360 amino acids |
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| ADH1-1353M | Recombinant Mouse ADH1 Protein | Mammalian Cells | Mouse | His |
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| Adh1-778M | Recombinant Mouse Adh1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Glu25~Asp228 |
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| ADH1-342M | Recombinant Mouse ADH1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ADH1-342M-B | Recombinant Mouse ADH1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Adh1-541M | Recombinant Mouse Adh1 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
ADH1 involved in several pathways and played different roles in them. We selected most pathways ADH1 participated on our site, such as Glycolysis / Gluconeogenesis,Fatty acid degradation,Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Retinol metabolism | PNPLA4,UGT1A1,UGT1A3,RDH10B,UGT1A6B,DHRS4,CYP2C55,RDH8B,CYP2C37,UGT1A6A |
| Metabolism of xenobiotics by cytochrome P | GSTM2,GSTM,ALDH3B1,GSTA,UGT1A9,CYP1A,MGST2,DHDH,UGT1A6,GSTP1 |
| Tyrosine metabolism | FAH,AOC2,GOT2A,ALDH3A1,COMTB,AOX3L1,IL4I1,ALDH3B2,COMTA,AOX4 |
| Metabolic pathways | ST6GAL1,NANS,AKR1C4,PLA2G5,EHHADH,CYP7A1A,NOS2,PLA2G7,MUT,PIK3C2A |
| Fatty acid degradation | CPT1A,GCDH,ALDH2.2,ACSL1,ADH7,ALDH9A1A.1,ACSL3A,ECI2,ACSL5,HADH |
| Glycolysis / Gluconeogenesis | TPI1,PGAM1A,ALDH2.2,ALDOC,PFKM,LDHAL6B,LDHA,TPI1A,ADH2-2,GPI1 |
| Chemical carcinogenesis | ALDH1A3,UGT2A2,GSTO2,CYP2C8,CHRNA7,CCBL2,UGT1A7C,UGT1A7,ADH6,GSTM1 |
| Drug metabolism - cytochrome P | UGT2A3,UGT1A2,MGST1.2,UGT1A6B,UGT2A2,MGST1,AOX3,FMO4,UGT1A6,GSTT2 |
Protein Function
ADH1 has several biochemical functions, for example, NAD binding,alcohol dehydrogenase (NAD) activity,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH1 itself. We selected most functions ADH1 had, and list some proteins which have the same functions with ADH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alcohol dehydrogenase (NAD) activity | ADH8B,ADH5,ADH1A,ADH8A,ADH1C,DHRS9,ADH4,ADH7,ADH6 |
| protein homodimerization activity | ANO6,SLC39A13,BCL2A,JUP,GDF6,EPHX2,ZFP652,GGCT,GNPTG,CEBPE |
| oxidoreductase activity | DHRS3A,CYP2A12,OSGIN1,TRR1,HMGCRA,CYP2K16,IMPDH1B,AKR1A1A,RPS6KL1,CMAH |
| drug binding | PDXK,SRP54A,CHRM2,DRD3,SMO,CYP2D6,CHRNA2,PPP3CA,GPR30,CYP4B1 |
| ethanol binding | ADH7,ADH4,PRKCE |
| retinol dehydrogenase activity | RDH8,SDR16C5,RDH11,ADH7,DHRS9,DHRS3,RDH5,RDH7,RDH1,HSD17B6 |
| zinc ion binding | WHSC1L1,ZBTB32,ZCCHC7,ABP1,CSRP3,TRIM58,SH3RF1,BIRC3,TRIM7,PAPLN |
| NAD binding | UGDH,PHGDH,LDHB,GPD1,HSD11B2,GRHPR,CTBP1,IDH3G,GAPDH,HSD17B10 |
| metal ion binding | CENPT,MPPED2,GIT2A,PLEKHM1,PPM1DA,IMPDH1A,TRIM43C,ZFP689,TRAF4A,POLR3A |
Interacting Protein
ADH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH1.
Ywhae;Ywhaz;Pgls;Hsd3b7
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References
- Ardizzoni, A; Posteraro, B; et al. AN ANTIBODY REACTIVITY-BASED ASSAY FOR DIAGNOSIS OF INVASIVE CANDIDIASIS USING PROTEIN ARRAY. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 27:403-412(2014).
- Chiang, CP; Wu, CW; et al. Expression Pattern, Ethanol-Metabolizing Activities, and Cellular Localization of Alcohol and Aldehyde Dehydrogenases in Human Small Intestine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:2047-2058(2012).
