ADH1
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Official Full Name
Adh1p
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Overview
Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene. -
Synonyms
ADH1; Adh1p; ADC1; ADH alpha subunit; ADH; ADH1A; Alcohol dehydrogenase 1; Aldehyde reductase; YADH 1; EC 1.1.1.1EC 1.1.1.190Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Entamoeba Histolytica
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|T7
- MYC
- DDK
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Mouse | Adh1-778M | Recombinant Mouse Adh1 protein, His & T7-tagged | E.coli | His/T7 | Glu25~Asp228 (Accession # P00329) | |
Mouse | ADH1-1353M | Recombinant Mouse ADH1 Protein | Mammalian Cell | His | ||
Mouse | Adh1-541M | Recombinant Mouse Adh1 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Mouse | ADH1-342M-B | Recombinant Mouse ADH1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ADH1-342M | Recombinant Mouse ADH1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Entamoeba Histolytica | ADH1-156 | Active Recombinant Entamoeba histolytica ADH1 protein, His-tagged | E.coli | His | 360 amino acids |
- Involved Pathway
- Protein Function
- Interacting Protein
- ADH1 Related Articles
ADH1 involved in several pathways and played different roles in them. We selected most pathways ADH1 participated on our site, such as Glycolysis / Gluconeogenesis, Fatty acid degradation, Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycolysis / Gluconeogenesis | ENO3;PDHA1B;AKR1A1;PCK2;HK3;ALDOCB;ADH6;ALDH9A1B;GPI |
Fatty acid degradation | ACADS;ALDH9A1B;ACAT1;ALDH2.1;ALDH1B1;ALDH9A1;ADH1C;HADHAB;HADHB |
Tyrosine metabolism | GOT2B;COMTB;MIF;COMTA;FAHD1;TYRP1;TH;AOX2P;GOT2 |
Retinol metabolism | CYP3A41A;UGT1A6A;ALDH1A2;UGT1A6B;RDH8A;SDR16C5;UGT1A7;DHRS4;UGT1A3 |
Metabolism of xenobiotics by cytochrome P | UGT1A6A;UGT1A1;CYP1A;GSTA1;UGT1A3;GSTM6;SULT2A1;UGT1A7C;DHDHL |
Drug metabolism - cytochrome P | MGST1.1;MGST1;FMO3;UGT2B7;ADH1;FMO4;GSTM7;ALDH3B1;FMO6P |
Metabolic pathways | GLUD1A;MPI;Atp5g2;Atp5k;ATP5F1;DCXR;PAH;DEGS2;NMNAT3 |
Chemical carcinogenesis | CYP2B19;GSTA2;GSTO2;CYP2C54;UGT1A6B;ADH1;GSTM3;UGT2B7;GSTP2 |
ADH1 has several biochemical functions, for example, NAD binding, alcohol dehydrogenase (NAD) activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH1 itself. We selected most functions ADH1 had, and list some proteins which have the same functions with ADH1. You can find most of the proteins on our site.
Function | Related Protein |
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NAD binding | CTBP2A;NDUFV1;GPD1A;IDH2;CTBP1;GRHPRB;HSD3B5;HIBADHA;HPGD |
alcohol dehydrogenase (NAD) activity | ADH5;ADH8A;ADH7;ADH1C;ADH1A;ADH8B;DHRS9;ADH6;ADH1 |
drug binding | FSCN1;DHFR;HMGCS1;CHRNA7;PYGM;PDE4C;GABRA1;PNP;SLC6A4A |
ethanol binding | ADH7;PRKCE;ADH1;ADH4 |
metal ion binding | RASA3;CYB5R4;GFI1B;PDSS1;NCALDB;MORC2A;NPTXR;RHEBL1;PITPNM1 |
oxidoreductase activity | AKR1B8;RDH14A;Akr1b3;LOXL2A;DHRS7CB;SDR42E1;SCCPDHB;PYROXD2;HSD17B6 |
protein homodimerization activity | CRYM;FLT3LG;PDGFA;QPRT;MYH9;GNPTG;KLHL7;STUB1;MAPK4 |
retinol dehydrogenase activity | DHRS3;RDH1;RDH10;RDH12;RDH11;DHRS7C;ADH7;BMP2;AKR1C3 |
zinc ion binding | MT1F;PARK2;WT1;TRIM67;TRIM27;ING1;SRSF7A;XRN2;PDLIM5 |
ADH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH1.
Ywhae; Ywhaz; Pgls; Hsd3b7
- Q&As
- Reviews
Q&As (10)
Ask a questionAdh1 plays a significant role in alcohol metabolism, showing specific catalytic efficiency and substrate specificity for the conversion of alcohol to acetaldehyde.
Pharmacological agents or environmental factors can modulate Adh1 expression or activity, potentially influencing alcohol metabolism and providing avenues for therapeutic interventions or personalized medicine.
The expression of Adh1 is regulated by specific mechanisms, including transcriptional and post-transcriptional regulation, which can respond to alcohol exposure or metabolic factors such as hormonal signaling.
Adh1 requires specific cofactors or coenzymes, such as NAD+ or NADH, for its activity, serving as electron carriers and modulators of Adh1 function.
Adh1 deficiency or knockout in experimental models leads to altered alcohol metabolism and related phenotypes, such as decreased alcohol clearance and increased sensitivity to alcohol-induced effects.
Adh1 expression or activity may vary among different species or populations, influenced by genetic and environmental factors, contributing to inter-individual or inter-species differences in alcohol metabolism and tolerance.
The structural features of Adh1, such as its active site and binding domains, are critical for its enzymatic activity and substrate recognition, enabling efficient alcohol oxidation.
Adh1 has the capacity to metabolize other substrates beyond alcohol, suggesting its involvement in broader metabolic pathways and potential metabolic interactions.
Genetic variations or polymorphisms in the Adh1 gene have been associated with differences in alcohol metabolism and susceptibility to alcohol-related disorders, highlighting the impact of genotype on phenotype.
Adh1 exhibits a tissue-specific expression pattern, with higher expression levels in certain organs such as the liver, and its distribution may differ from other ADH isoforms, reflecting functional specialization.
Customer Reviews (2)
Write a reviewHighly effective in blocking protein-protein interactions in competition assays.
Shows excellent target engagement and modulation in drug discovery studies.
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