ADH1B
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Official Full Name
alcohol dehydrogenase 1B (class I), beta polypeptide
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Overview
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. -
Synonyms
ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide; ADH2; alcohol dehydrogenase 1B; ADH beta subunit; ADH1B_HUMAN; alcohol dehydrogenase 2 (class I), beta polypeptide; Alcohol dehydrogenase 2; Alcohol dehydrogenase subunit beta; Aldehyde reductase; DKFZp686C06125; OTTHUMP00000220192; ADH, beta subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Antibody
- Cynomolgus Monkey
- Human
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- ADH1B Related Articles
ADH1B involved in several pathways and played different roles in them. We selected most pathways ADH1B participated on our site, such as Biological oxidations, Chemical carcinogenesis, Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | CYP1A2;FDXR;CYP2J2;MTRR;CYP46A1;ADH8A;CYP7A1;CYP2N13;ADH4 |
| Chemical carcinogenesis | GSTM5;ADH7;CYP3A7-CYP3AP1;GSTA4;GSTM3;ADH2-1;GSTM1;CYP2C38;ARNT |
| Drug metabolism - cytochrome P450 | GSTK1;ADH6;CYP2C9;CYP2C19;ADH1C;CYP3A5;CYP2C8;ADH4;CYP2E1 |
| Ethanol oxidation | ADH5;ADH6;ADH1C;ADH7;ADH1A;ADH1B;ADH8A;ADH4;ADH8B |
| Fatty Acid Omega Oxidation | CYP2E1;ADH1C;ADH6;CYP2D6;CYP2A6;ADH7;ADH1B;ADH1A;CYP1A1 |
| Fatty acid degradation | CYP4A12A;ADH1C;ADH6;HADHAB;ACSL1B;CPT1C;ACSL1A;ADH2-1;ALDH2 |
| Glycolysis / Gluconeogenesis | ENO3;ADH2-2;ADH6;LDHC;LDHAL6A;pykF;PFKMA;PCK2;LDHB |
| Metabolic pathways | ALG10B;AK5;MAT2AL;ACSS1;PIGN;UCK1;CYP11C1;AK4;SRM |
ADH1B has several biochemical functions, for example, alcohol dehydrogenase activity, zinc-dependent, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH1B itself. We selected most functions ADH1B had, and list some proteins which have the same functions with ADH1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alcohol dehydrogenase activity, zinc-dependent | ADH7;ADH1B;ADH1A;ADH4 |
| zinc ion binding | EHMT1;ZRANB2;CXXC1;ATXN7L3;ADAMTS18;ZNF331;RNF175;EWSR1B;ZBBX |
ADH1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH1B.
SERPINA3; PML; GNB2L1; PDE4DIP; yvcN; ykwC; IRAK3
- Q&As
- Reviews
Q&As (10)
Ask a questionADH1B deficiency or knockout in experimental models leads to altered alcohol metabolism and related phenotypes, such as decreased alcohol clearance and increased sensitivity to alcohol-induced effects.
ADH1B plays a significant role in alcohol metabolism, showing specific catalytic efficiency and substrate specificity for the conversion of alcohol to acetaldehyde.
Pharmacological agents or environmental factors can modulate ADH1B expression or activity, potentially influencing alcohol metabolism and providing avenues for therapeutic interventions or personalized medicine.
Genetic variations or polymorphisms in the ADH1B gene have been associated with differences in alcohol metabolism and susceptibility to alcohol-related disorders, highlighting the impact of genotype on phenotype.
ADH1B has the capacity to metabolize other substrates beyond alcohol, suggesting its involvement in broader metabolic pathways and potential metabolic interactions.
ADH1B expression or activity may vary among different species or populations, influenced by genetic and environmental factors, contributing to inter-individual or inter-species differences in alcohol metabolism and tolerance.
ADH1B exhibits a tissue-specific expression pattern, with higher expression levels in certain organs such as the liver, and its distribution may differ from other ADH isoforms, reflecting functional specialization.
The structural features of ADH1B, such as its active site and binding domains, are critical for its enzymatic activity and substrate recognition, enabling efficient alcohol oxidation.
There may be interacting proteins or partners of ADH1B that influence its function or localization, potentially modulating its enzymatic activity or cellular processes.
The expression of ADH1B is regulated by specific mechanisms, including transcriptional and post-transcriptional regulation, which can respond to alcohol exposure or metabolic factors such as hormonal signaling.
Customer Reviews (2)
Write a reviewShows outstanding biocompatibility and low cytotoxicity in cell culture experiments.
Displays excellent resistance to denaturation by chaotropic agents in stability assays.
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