Description : |
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. |
Source : |
Mammalian cells |
Species : |
Human |
Tag : |
Flag |
Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : |
39.7 kDa |
AA Sequence : |
MSTAGKVIKCKAAVLWEVKKPFSIE DVEVAPPKAYEVRIKMVAVGICRTD DHVVSGNLVTPLPVILGHEA AGIVESVGEGVTTVKPGDKVIPLFT PQCGKCRVCKNPESNYCLKNDLGNP RGTLQDGTRRFTCRGKPIHH FLGTSTFSQYTVVDENAVAKIDAAS PLEKVCLIGCGFSTGYGSAVNVAKV TPGSTCAVFGLGGVGLSAVM GCKAAGAARIIAVDINKDKFAKAKE LGATECINPQDYKKPIQEVLKEMTD GGVDFSFEVIGRLDTMMASL LCCHEACGTSVIVGVPPASQNLSIN PMLLLTGRTWKGAVYGGFKSKEGIP KLVADFMAKKFSLDALITHV LPFEKINEGFDLLHSGKSIRTVLTF TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : |
Store at -80 centigrade. |
Concentration : |
>50 ug/mL as determined by microplate BCA method. |
Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : |
Druggable Genome |
Protein Pathways : |
Drug metabolism - cytochrome P450, Fatty acid metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism, Tyrosine metabolism |