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ADH1C

  • Official Full Name

    alcohol dehydrogenase 1C (class I), gamma polypeptide

  • Overview

    This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.
  • Synonyms

    ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide; ADH3; alcohol dehydrogenase 1C; Alcohol dehydrogenase 3; Class I alcohol dehydrogenase; ADH gamma subunit; ADH1G_HUMAN; Alcohol dehydrogenase 1C (class I) gamma polypeptide; Alcohol dehydrogenase 1C gamma polypeptide; Alcohol dehydrogenase 3 (class I) gamma polypeptide; Alcohol dehydrogenase subunit gamma; Aldehyde reductase; OTTHUMP00000220209; ADH, gamma subunit; alcohol dehydrogenase 3 (class I), gamma polypeptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADH1C-2480H Recombinant Human Alcohol Dehydrogenase 1C (class I), Gamma Polypeptide, His-tagged E.coli His 1-375aa
Human ADH1C-346H Recombinant Human ADH1C Protein, GST-tagged Wheat Germ GST
Human ADH1C-9418H Recombinant Human ADH1C, His-tagged E.coli His 1-374a.a.
Human ADH1C-9013HCL Recombinant Human ADH1C 293 Cell Lysate HEK293 N/A
Human ADH1C-925HF Recombinant Full Length Human ADH1C Protein, GST-tagged In Vitro Cell Free System GST 375 amino acids
Human ADH1C-0055H Recombinant Human ADH1C Protein (S2-F375), Tag Free E.coli No tag S2-F375
Human ADH1C-100H Recombinant Human ADH1C Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human ADH1C-77H Recombinant Human ADH1C Protein, His&GST-tagged E.coli N-His&GST Ser2-Phe375
Human ADH1C-2487H Recombinant Human ADH1C protein, GST-tagged E.coli GST 1-375aa
Human ADH1C-0056H Recombinant Human ADH1C Protein (S2-F375), His tagged E.coli His S2-F375
Human ADH1C-09HF Recombinant Full Length Human ADH1C Protein In Vitro Cell Free System 375 amino acids
Human ADH1C-27094TH Recombinant Human ADH1C Wheat Germ N/A 375 amino acids
Rat ADH1C-523R Recombinant Rat ADH1C Protein Mammalian Cell His
Rat ADH1C-179R Recombinant Rat ADH1C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADH1C-179R-B Recombinant Rat ADH1C Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADH1C Related Articles

ADH1C involved in several pathways and played different roles in them. We selected most pathways ADH1C participated on our site, such as Biological oxidations, Chemical carcinogenesis, Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsCYP2C9;CYP2D6;SULT2ST2;CYP4B1;DPEP2;ADH8B;SLC35D1A;CYP3A7;CES1
Chemical carcinogenesisUGT2A1;CYP3A7-CYP3AP1;CYP2C8;UGT1A6B;GSTO2;ADH1C;SULT2A1;GSTP2;CYP2E1
Drug metabolism - cytochrome P450ADH1B;ADH2-1;GSTO2;CYP2C8;CYP2C19;CYP3A5;ADH6;ADH1C;CYP2B6
Ethanol oxidationADH1B;ADH4;ADH5;ADH8A;ADH1A;ADH8B;ADH6;ADH7;ADH1C
Fatty Acid Omega OxidationADH1B;ADH1A;CYP4A11;CYP2D6;CYP2A6;CYP2E1;ADH1C;ADH7;ADH4
Fatty acid degradationCYP4A12A;ALDH9A1A.1;HADHAA;ADH1A;ACAA1;ACSL1B;ADH2-1;CPT2;ACSL3A
Glycolysis / GluconeogenesisPGAM1B;PFKMB;PFKL;ALDH9A1B;ALDOC;ALDOAA;LDHC;PKMB;PKMA
Metabolic pathwaysNDUFS3;GCDH;GBA3;AKR1B1L;INPP5L;UGT8A;NFS1;KDSR;SEPHS2

ADH1C has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH1C itself. We selected most functions ADH1C had, and list some proteins which have the same functions with ADH1C. You can find most of the proteins on our site.

Function Related Protein
alcohol dehydrogenase (NAD) activityADH7;ADH8B;ADH1;ADH4;ADH5;ADH6;ADH1A;ADH8A;DHRS9
zinc ion bindingADAM33;BRD1B;MT1E;LHX4;MORC2B;CPA6;MAN2B1;NR5A1;MARCH1

ADH1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH1C here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH1C.

Chiang, CP; Wu, CW; et al. Expression Pattern, Ethanol-Metabolizing Activities, and Cellular Localization of Alcohol and Aldehyde Dehydrogenases in Human Small Intestine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:2047-2058(2012).
Chiang, CP; Jao, SW; et al. Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer. ALCOHOL 46:37-49(2012).
  • Q&As
  • Reviews

Q&As (10)

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What are the structural features of ADH1C, and how do they relate to its enzymatic activity and substrate binding? 06/23/2022

The structural features of ADH1C, such as its active site and binding domains, are critical for its enzymatic activity and substrate recognition, enabling efficient alcohol oxidation.

How does the expression or activity of ADH1C change in response to pharmacological agents or environmental factors, and what are the implications for alcohol metabolism or therapy? 02/18/2021

Pharmacological agents or environmental factors can modulate ADH1C expression or activity, potentially influencing alcohol metabolism and providing avenues for therapeutic interventions or personalized medicine.

Can ADH1C metabolize other substrates apart from alcohol, and what are the implications for its broader metabolic role? 05/31/2020

ADH1C has the capacity to metabolize other substrates beyond alcohol, suggesting its involvement in broader metabolic pathways and potential metabolic interactions.

Are there any known genetic variations or polymorphisms in the ADH1C gene associated with differences in alcohol metabolism or susceptibility to alcohol-related disorders? 04/23/2020

Genetic variations or polymorphisms in the ADH1C gene have been associated with differences in alcohol metabolism and susceptibility to alcohol-related disorders, highlighting the impact of genotype on phenotype.

How does ADH1C expression or activity vary in different species or populations, and what are the underlying genetic and environmental factors influencing these variations? 04/07/2020

ADH1C expression or activity may vary among different species or populations, influenced by genetic and environmental factors, contributing to inter-individual or inter-species differences in alcohol metabolism and tolerance.

What is the tissue-specific expression pattern of ADH1C, and how does it differ from other ADH isoforms in terms of its expression levels and distribution across organs and cell types? 10/13/2019

ADH1C exhibits a tissue-specific expression pattern, with higher expression levels in certain organs such as the liver, and its distribution may differ from other ADH isoforms, reflecting functional specialization.

How does ADH1C contribute to alcohol metabolism, and what is its catalytic efficiency and substrate specificity compared to other ADH isoforms? 07/13/2018

ADH1C plays a significant role in alcohol metabolism, showing specific catalytic efficiency and substrate specificity for the conversion of alcohol to acetaldehyde.

What are the regulatory mechanisms controlling ADH1C expression, and how do they respond to alcohol exposure or other metabolic factors? 12/29/2017

The expression of ADH1C is regulated by specific mechanisms, including transcriptional and post-transcriptional regulation, which can respond to alcohol exposure or metabolic factors such as hormonal signaling.

Are there any interacting proteins or partners of ADH1C that influence its function or localization? 12/17/2017

There may be interacting proteins or partners of ADH1C that influence its function or localization, potentially modulating its enzymatic activity or cellular processes.

What are the consequences of ADH1C deficiency or knockout in experimental models, and how does it affect alcohol metabolism and related phenotypes? 12/12/2017

ADH1C deficiency or knockout in experimental models leads to altered alcohol metabolism and related phenotypes, such as decreased alcohol clearance and increased sensitivity to alcohol-induced effects.

Customer Reviews (2)

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Reviews
04/03/2020

    Highly specific in recognizing and cleaving target substrates in protease assays.

    12/20/2018

      Provides efficient and accurate quantification of post-translational modifications in PTM studies.

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