ADH1C
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Official Full Name
alcohol dehydrogenase 1C (class I), gamma polypeptide
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Overview
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. -
Synonyms
ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide; ADH3; alcohol dehydrogenase 1C; Alcohol dehydrogenase 3; Class I alcohol dehydrogenase; ADH gamma subunit; ADH1G_HUMAN; Alcohol dehydrogenase 1C (class I) gamma polypeptide; Alcohol dehydrogenase 1C gamma polypeptide; Alcohol dehydrogenase 3 (class I) gamma polypeptide; Alcohol dehydrogenase subunit gamma; Aldehyde reductase; OTTHUMP00000220209; ADH, gamma subunit; alcohol dehydrogenase 3 (class I), gamma polypeptide;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- Myc
- DDK
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- ADH1C Related Articles
ADH1C involved in several pathways and played different roles in them. We selected most pathways ADH1C participated on our site, such as Biological oxidations, Chemical carcinogenesis, Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Biological oxidations | CYP2C9;CYP2D6;SULT2ST2;CYP4B1;DPEP2;ADH8B;SLC35D1A;CYP3A7;CES1 |
Chemical carcinogenesis | UGT2A1;CYP3A7-CYP3AP1;CYP2C8;UGT1A6B;GSTO2;ADH1C;SULT2A1;GSTP2;CYP2E1 |
Drug metabolism - cytochrome P450 | ADH1B;ADH2-1;GSTO2;CYP2C8;CYP2C19;CYP3A5;ADH6;ADH1C;CYP2B6 |
Ethanol oxidation | ADH1B;ADH4;ADH5;ADH8A;ADH1A;ADH8B;ADH6;ADH7;ADH1C |
Fatty Acid Omega Oxidation | ADH1B;ADH1A;CYP4A11;CYP2D6;CYP2A6;CYP2E1;ADH1C;ADH7;ADH4 |
Fatty acid degradation | CYP4A12A;ALDH9A1A.1;HADHAA;ADH1A;ACAA1;ACSL1B;ADH2-1;CPT2;ACSL3A |
Glycolysis / Gluconeogenesis | PGAM1B;PFKMB;PFKL;ALDH9A1B;ALDOC;ALDOAA;LDHC;PKMB;PKMA |
Metabolic pathways | NDUFS3;GCDH;GBA3;AKR1B1L;INPP5L;UGT8A;NFS1;KDSR;SEPHS2 |
ADH1C has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH1C itself. We selected most functions ADH1C had, and list some proteins which have the same functions with ADH1C. You can find most of the proteins on our site.
Function | Related Protein |
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alcohol dehydrogenase (NAD) activity | ADH7;ADH8B;ADH1;ADH4;ADH5;ADH6;ADH1A;ADH8A;DHRS9 |
zinc ion binding | ADAM33;BRD1B;MT1E;LHX4;MORC2B;CPA6;MAN2B1;NR5A1;MARCH1 |
ADH1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH1C here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH1C.
- Q&As
- Reviews
Q&As (10)
Ask a questionThe structural features of ADH1C, such as its active site and binding domains, are critical for its enzymatic activity and substrate recognition, enabling efficient alcohol oxidation.
Pharmacological agents or environmental factors can modulate ADH1C expression or activity, potentially influencing alcohol metabolism and providing avenues for therapeutic interventions or personalized medicine.
ADH1C has the capacity to metabolize other substrates beyond alcohol, suggesting its involvement in broader metabolic pathways and potential metabolic interactions.
Genetic variations or polymorphisms in the ADH1C gene have been associated with differences in alcohol metabolism and susceptibility to alcohol-related disorders, highlighting the impact of genotype on phenotype.
ADH1C expression or activity may vary among different species or populations, influenced by genetic and environmental factors, contributing to inter-individual or inter-species differences in alcohol metabolism and tolerance.
ADH1C exhibits a tissue-specific expression pattern, with higher expression levels in certain organs such as the liver, and its distribution may differ from other ADH isoforms, reflecting functional specialization.
ADH1C plays a significant role in alcohol metabolism, showing specific catalytic efficiency and substrate specificity for the conversion of alcohol to acetaldehyde.
The expression of ADH1C is regulated by specific mechanisms, including transcriptional and post-transcriptional regulation, which can respond to alcohol exposure or metabolic factors such as hormonal signaling.
There may be interacting proteins or partners of ADH1C that influence its function or localization, potentially modulating its enzymatic activity or cellular processes.
ADH1C deficiency or knockout in experimental models leads to altered alcohol metabolism and related phenotypes, such as decreased alcohol clearance and increased sensitivity to alcohol-induced effects.
Customer Reviews (2)
Write a reviewHighly specific in recognizing and cleaving target substrates in protease assays.
Provides efficient and accurate quantification of post-translational modifications in PTM studies.
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