ADRA2C
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Official Full Name
adrenergic, alpha-2C-, receptor
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Overview
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. -
Synonyms
ADRA2C; adrenergic, alpha-2C-, receptor; ADRA2L2, ADRA2RL2; alpha-2C adrenergic receptor; ADRARL2; alpha-2CAR; alpha2-AR-C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; alpha-2 adrenergic receptor subtype C4; ADRA2L2; ADR;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cavia porcellus (Guinea pig)
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli expression system
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ADRA2C Related Articles
- ADRA2C Related Research Area
ADRA2C involved in several pathways and played different roles in them. We selected most pathways ADRA2C participated on our site, such as Adrenaline signalling through Alpha-2 adrenergic receptor, Adrenaline,noradrenaline inhibits insulin secretion, Adrenoceptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRA2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adrenaline signalling through Alpha-2 adrenergic receptor | ADRA2B;ADRA2C;ADRA2A |
Adrenaline,noradrenaline inhibits insulin secretion | ADRA2C;GNB3A;GNB5A;GNB3B;GNB5;ADCY6;GNB5B;ADRA2A |
Adrenoceptors | ADRB3;ADRB1;ADRA2B;ADRA1B;ADRA2A;ADRB2;ADRa1A;ADRA1D;ADRA2C |
Amine ligand-binding receptors | ADRA2A;ADRB1;ADRa1A;DRD2;CHRM3;ADRA1D;ADRA1B;ADRB2;CHRM1 |
Class A/1 (Rhodopsin-like receptors) | CCR9;OPN5;PROKR2;SSTR5;ADORA1;CYSLTR1;EDN2;ADRB3;PROKR1A |
G alpha (i) signalling events | CCR3;RGS4;RLN3;ADRA2C;PMCH;CXCL11.8;CASR;OXGR1A.1;TAS2R13 |
G alpha (z) signalling events | RGS19;ADRA2C;ADRA2A;RGS20;RGS4;RGS17;ADRA2B |
GPCR downstream signaling | VIP;LPAR5A;PROK1;SSTR4;DRD4;PLEKHG2;CXCR7B;GPR4;ADRB3 |
ADRA2C has several biochemical functions, for example, alpha-2A adrenergic receptor binding, alpha2-adrenergic receptor activity, epinephrine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRA2C itself. We selected most functions ADRA2C had, and list some proteins which have the same functions with ADRA2C. You can find most of the proteins on our site.
Function | Related Protein |
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alpha-2A adrenergic receptor binding | ADRBK1;ADRB1;UCHL1;ADRA2C;APLP1 |
alpha2-adrenergic receptor activity | ADRA2DA;ADRA2A;ADRA2DB;ADRA2B;ADRA2C |
epinephrine binding | ADRB2B;ADRA2C;ADRA2A;ADRB2A;ADRA2B;ADRB2;ADRB3A;ADRB3;ADRB3B |
protein binding | ZBTB2;SMYD2;TTC19;DOCK10;LURAP1;PHF15;KCTD15;ORMDL3;C1orf216 |
protein heterodimerization activity | JDP2;Defa-rs7;GABPB2;ATF1;CEBPA;BMP2B;RAB3GAP2;HER11;EFHA1 |
protein homodimerization activity | TARBP2;ATF3;STK25;PEX11B;SYNE1;FLNA;TENM3;SLC9A7;ZHX3 |
ADRA2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRA2C here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRA2C.
- Q&As
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Q&As (18)
Ask a questionGenetic variations in the ADRA2C gene can affect the function of ADRA2C receptors and contribute to the development of various medical conditions. Identifying these variations can help clinicians develop more personalized treatments for patients with these conditions, and may also improve our understanding of the underlying mechanisms involved in adrenergic signaling.
Yes, ADRA2C dysfunction can affect children and adolescents, particularly in the case of ADHD. However, children and adolescents may require different treatment strategies than adults. It is important for healthcare providers to carefully evaluate and monitor children and adolescents with ADRA2C dysfunction to ensure proper management and appropriate medication dosing.
ADRA2C-targeted treatments may be used in combination with other therapies to improve patient outcomes. For example, they could be used alongside traditional antidepressant medications to improve treatment response in patients with depression. In patients with hypertension, ADRA2C-targeted treatments may be used in combination with other antihypertensive drugs to achieve better blood pressure control.
Yes, ongoing research continues to explore the role of ADRA2C in the development and progression of medical conditions such as hypertension, depression, and ADHD. Additionally, researchers are exploring the potential use of ADRA2C-targeted medications for the treatment of these conditions, and the development of more targeted and effective therapies is ongoing.
ADRA2C proteins are a subtype of adrenergic receptors found in various tissues throughout the body. These receptors play a crucial role in regulating the activity of the sympathetic nervous system, which controls many vital bodily processes, including the regulation of blood pressure and heart rate.
There are several different approaches to targeting ADRA2C proteins for medical treatments, including the development of drugs that can selectively bind to and activate or inhibit these receptors. These drugs can be used to regulate the activity of the sympathetic nervous system and potentially treat a range of conditions associated with dysregulation of adrenergic signaling.
While some cases of ADRA2C dysfunction may be due to inherited genetic variations or medical conditions that cannot be prevented, certain lifestyle choices may help reduce the risk of adrenergic dysfunction. For example, maintaining a healthy diet, getting regular exercise, reducing stress, and avoiding tobacco and excessive alcohol consumption may help regulate ADRA2C function and prevent related medical conditions such as hypertension and depression.
ADRA2C dysfunction can be evaluated and diagnosed through various physiological and psychiatric tests and assessments, including blood pressure monitoring, electrocardiogram (ECG) tests, attention tests, and psychological evaluations. Genetic testing may also be performed to identify any genetic variations that may impact ADRA2C function.
Developing ADRA2C-targeted treatments presents several challenges. For example, it can be difficult to develop drugs that selectively target ADRA2C without affecting other adrenergic receptors. Additionally, genetic variations that influence ADRA2C function can make it difficult to predict patient response to treatments. Finally, the complex interactions between the adrenergic system and other physiological systems pose a challenge when trying to develop effective treatments.
ADRA2C proteins differ from other types of adrenergic receptors in terms of their structure, function, and distribution throughout the body. Unlike other adrenergic receptors, ADRA2C proteins primarily bind to the neurotransmitter norepinephrine, and they are found in a relatively small number of tissues.
While there is limited research on natural supplements or herbs specifically targeting ADRA2C function, some natural remedies may have indirect effects on the adrenergic system. For example, certain herbal remedies such as ashwagandha, ginseng, and rhodiola have been shown to reduce stress and improve mood, potentially impacting the adrenergic system. However, it is important to discuss the use of natural supplements with a healthcare provider to ensure they are safe and appropriate for individual use.
Like all medications, ADRA2C-targeted treatments can have side effects. Some of the potential side effects associated with these treatments include changes in heart rate and blood pressure, sleep disturbances, gastrointestinal issues, and changes in mood or behavior. The specific side effects will depend on the type of treatment and the individual patient.
Like any medication, there is the potential for side effects with ADRA2C-targeted treatments. Common side effects may include dizziness, headaches, constipation, and dry mouth. Some patients may also experience changes in heart rate or blood pressure, particularly if they are taking other medications that impact the adrenergic system.
While medication is often necessary for patients with adrenergic dysfunction, there are also lifestyle changes that can help regulate ADRA2C function and improve overall health. For example, maintaining a healthy diet, getting regular exercise, reducing stress, and avoiding tobacco and excessive alcohol consumption may all have a positive impact on the adrenergic system. Additionally, regular sleep patterns and good sleep hygiene may improve overall adrenergic regulation.
ADRA2C dysfunction has been linked to several mental health conditions, including depression, anxiety, and attention-deficit/hyperactivity disorder (ADHD). Research suggests that alterations in adrenergic function, including changes in ADRA2C levels and activity, may play a role in the development and progression of these conditions. Targeting ADRA2C with medication may therefore be a promising treatment approach for individuals with these conditions.
Many researchers are currently studying ADRA2C proteins and their potential role in various medical conditions. Some studies are focused on developing new drugs that can selectively target and regulate ADRA2C function, while others are exploring the genetic and environmental factors that influence ADRA2C regulation and function.
Adrenergic dysfunction has been associated with several medical conditions, including hypertension, anxiety disorders, depression, and attention deficit hyperactivity disorder (ADHD). The precise role that ADRA2C proteins play in these conditions can vary, and more research is needed to fully understand their function.
Lifestyle changes, such as regular exercise, stress reduction techniques, and a healthy diet, may help regulate ADRA2C function by reducing stress and promoting overall physical and mental health. Natural remedies, such as herbal supplements, may also be beneficial in some cases. However, more research is needed to fully understand the effects of these practices on ADRA2C function.
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