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ADRA2C

  • Official Full Name

    adrenergic, alpha-2C-, receptor

  • Overview

    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
  • Synonyms

    ADRA2C; adrenergic, alpha-2C-, receptor; ADRA2L2, ADRA2RL2; alpha-2C adrenergic receptor; ADRARL2; alpha-2CAR; alpha2-AR-C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; alpha-2 adrenergic receptor subtype C4; ADRA2L2; ADR;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Cavia porcellus (Guinea pig)
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADRA2C-8999HCL Recombinant Human ADRA2C 293 Cell Lysate HEK293 N/A
Mouse ADRA2C-1384M Recombinant Mouse ADRA2C Protein Mammalian Cell His
Mouse ADRA2C-364M Recombinant Mouse ADRA2C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADRA2C-364M-B Recombinant Mouse ADRA2C Protein Pre-coupled Magnetic Beads HEK293
Rat Adra2c-3334R Recombinant Rat Adra2c, His-tagged E.Coli or Yeast His 458
Rat ADRA2C-543R Recombinant Rat ADRA2C Protein Mammalian Cell His
Rat ADRA2C-199R-B Recombinant Rat ADRA2C Protein Pre-coupled Magnetic Beads HEK293
Rat ADRA2C-199R Recombinant Rat ADRA2C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cavia porcellus (Guinea pig) RFL8429CF Recombinant Full Length Guinea Pig Alpha-2C Adrenergic Receptor(Adra2C) Protein, His-Tagged E.coli expression system His Full Length (1-455)
Danio rerio (Zebrafish) (Brachydanio rerio) RFL815DF Recombinant Full Length Danio Rerio Alpha-2C Adrenergic Receptor(Adra2C) Protein, His-Tagged E.coli expression system His Full Length (1-432)
Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) RFL-15883DF Recombinant Full Length Didelphis Marsupialis Virginiana Alpha-2C Adrenergic Receptor(Adra2C) Protein, His-Tagged E.coli expression system His Full Length (1-469)
Homo sapiens (Human) RFL-8574HF Recombinant Full Length Human Alpha-2C Adrenergic Receptor(Adra2C) Protein, His-Tagged E.coli expression system His Full Length (1-462)
Rattus norvegicus (Rat) RFL-33709RF Recombinant Full Length Rat Alpha-2C Adrenergic Receptor(Adra2C) Protein, His-Tagged E.coli expression system His Full Length (1-458)
Zebrafish ADRA2C-11834Z Recombinant Zebrafish ADRA2C Mammalian Cell His
Kit-2182 cAMP ADRA2C CHO-K1 GPCR Assay Kit N/A
Kit-1111 Lipolysis (Adipocyte) Colorimetric/Fluorometric Assay Kit N/A
Kit-1039 Lysozyme Activity Assay Kit (Fluorometric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADRA2C Related Articles
  • ADRA2C Related Research Area

ADRA2C involved in several pathways and played different roles in them. We selected most pathways ADRA2C participated on our site, such as Adrenaline signalling through Alpha-2 adrenergic receptor, Adrenaline,noradrenaline inhibits insulin secretion, Adrenoceptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRA2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adrenaline signalling through Alpha-2 adrenergic receptorADRA2B;ADRA2C;ADRA2A
Adrenaline,noradrenaline inhibits insulin secretionADRA2C;GNB3A;GNB5A;GNB3B;GNB5;ADCY6;GNB5B;ADRA2A
AdrenoceptorsADRB3;ADRB1;ADRA2B;ADRA1B;ADRA2A;ADRB2;ADRa1A;ADRA1D;ADRA2C
Amine ligand-binding receptorsADRA2A;ADRB1;ADRa1A;DRD2;CHRM3;ADRA1D;ADRA1B;ADRB2;CHRM1
Class A/1 (Rhodopsin-like receptors)CCR9;OPN5;PROKR2;SSTR5;ADORA1;CYSLTR1;EDN2;ADRB3;PROKR1A
G alpha (i) signalling eventsCCR3;RGS4;RLN3;ADRA2C;PMCH;CXCL11.8;CASR;OXGR1A.1;TAS2R13
G alpha (z) signalling eventsRGS19;ADRA2C;ADRA2A;RGS20;RGS4;RGS17;ADRA2B
GPCR downstream signalingVIP;LPAR5A;PROK1;SSTR4;DRD4;PLEKHG2;CXCR7B;GPR4;ADRB3

ADRA2C has several biochemical functions, for example, alpha-2A adrenergic receptor binding, alpha2-adrenergic receptor activity, epinephrine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRA2C itself. We selected most functions ADRA2C had, and list some proteins which have the same functions with ADRA2C. You can find most of the proteins on our site.

Function Related Protein
alpha-2A adrenergic receptor bindingADRBK1;ADRB1;UCHL1;ADRA2C;APLP1
alpha2-adrenergic receptor activityADRA2DA;ADRA2A;ADRA2DB;ADRA2B;ADRA2C
epinephrine bindingADRB2B;ADRA2C;ADRA2A;ADRB2A;ADRA2B;ADRB2;ADRB3A;ADRB3;ADRB3B
protein bindingZBTB2;SMYD2;TTC19;DOCK10;LURAP1;PHF15;KCTD15;ORMDL3;C1orf216
protein heterodimerization activityJDP2;Defa-rs7;GABPB2;ATF1;CEBPA;BMP2B;RAB3GAP2;HER11;EFHA1
protein homodimerization activityTARBP2;ATF3;STK25;PEX11B;SYNE1;FLNA;TENM3;SLC9A7;ZHX3

ADRA2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRA2C here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRA2C.

Millan, MJ; La Cour, CM; et al. S33138[N-[4-[2-[(3aS, 9bR)-8-cyano-1,3a, 4,9b-tetrahydro[1]-benzopyrano[3,4-c] pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D-3 versus D-2 receptor antagonist and potential antipsychotic agent: I. Receptor-binding profile and functional actions at G-protein-coupled receptors. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 324:587-599(2008).
Vazquez, S; Mladovan, AG; et al. Human breast cell lines exhibit functional alpha(2)-adrenoceptors. CANCER CHEMOTHERAPY AND PHARMACOLOGY 58:50-61(2006).
  • Q&As
  • Reviews

Q&As (18)

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How can genetics influence ADRA2C function and associated medical conditions? 08/23/2022

Genetic variations in the ADRA2C gene can affect the function of ADRA2C receptors and contribute to the development of various medical conditions. Identifying these variations can help clinicians develop more personalized treatments for patients with these conditions, and may also improve our understanding of the underlying mechanisms involved in adrenergic signaling.

Does ADRA2C dysfunction affect children and adolescents? 06/25/2022

Yes, ADRA2C dysfunction can affect children and adolescents, particularly in the case of ADHD. However, children and adolescents may require different treatment strategies than adults. It is important for healthcare providers to carefully evaluate and monitor children and adolescents with ADRA2C dysfunction to ensure proper management and appropriate medication dosing.

How might ADRA2C-targeted treatments be used in combination with other therapies? 10/10/2021

ADRA2C-targeted treatments may be used in combination with other therapies to improve patient outcomes. For example, they could be used alongside traditional antidepressant medications to improve treatment response in patients with depression. In patients with hypertension, ADRA2C-targeted treatments may be used in combination with other antihypertensive drugs to achieve better blood pressure control.

Is there ongoing research on ADRA2C and its potential role in the development of medical conditions? 12/24/2020

Yes, ongoing research continues to explore the role of ADRA2C in the development and progression of medical conditions such as hypertension, depression, and ADHD. Additionally, researchers are exploring the potential use of ADRA2C-targeted medications for the treatment of these conditions, and the development of more targeted and effective therapies is ongoing.

What are ADRA2C proteins and what is their function in the body? 08/02/2020

ADRA2C proteins are a subtype of adrenergic receptors found in various tissues throughout the body. These receptors play a crucial role in regulating the activity of the sympathetic nervous system, which controls many vital bodily processes, including the regulation of blood pressure and heart rate.

How are ADRA2C proteins targeted for medical treatments? 03/23/2020

There are several different approaches to targeting ADRA2C proteins for medical treatments, including the development of drugs that can selectively bind to and activate or inhibit these receptors. These drugs can be used to regulate the activity of the sympathetic nervous system and potentially treat a range of conditions associated with dysregulation of adrenergic signaling.

Can ADRA2C dysfunction be prevented? 03/06/2020

While some cases of ADRA2C dysfunction may be due to inherited genetic variations or medical conditions that cannot be prevented, certain lifestyle choices may help reduce the risk of adrenergic dysfunction. For example, maintaining a healthy diet, getting regular exercise, reducing stress, and avoiding tobacco and excessive alcohol consumption may help regulate ADRA2C function and prevent related medical conditions such as hypertension and depression.

How is ADRA2C dysfunction evaluated and diagnosed in patients? 11/13/2019

ADRA2C dysfunction can be evaluated and diagnosed through various physiological and psychiatric tests and assessments, including blood pressure monitoring, electrocardiogram (ECG) tests, attention tests, and psychological evaluations. Genetic testing may also be performed to identify any genetic variations that may impact ADRA2C function.

What are some of the challenges associated with developing ADRA2C-targeted treatments? 12/14/2018

Developing ADRA2C-targeted treatments presents several challenges. For example, it can be difficult to develop drugs that selectively target ADRA2C without affecting other adrenergic receptors. Additionally, genetic variations that influence ADRA2C function can make it difficult to predict patient response to treatments. Finally, the complex interactions between the adrenergic system and other physiological systems pose a challenge when trying to develop effective treatments.

How do ADRA2C proteins differ from other types of adrenergic receptors? 08/26/2018

ADRA2C proteins differ from other types of adrenergic receptors in terms of their structure, function, and distribution throughout the body. Unlike other adrenergic receptors, ADRA2C proteins primarily bind to the neurotransmitter norepinephrine, and they are found in a relatively small number of tissues.

Are there any natural supplements or herbs that can regulate ADRA2C function? 04/09/2018

While there is limited research on natural supplements or herbs specifically targeting ADRA2C function, some natural remedies may have indirect effects on the adrenergic system. For example, certain herbal remedies such as ashwagandha, ginseng, and rhodiola have been shown to reduce stress and improve mood, potentially impacting the adrenergic system. However, it is important to discuss the use of natural supplements with a healthcare provider to ensure they are safe and appropriate for individual use.

What are some of the potential side effects of ADRA2C-targeted medical treatments? 02/12/2018

Like all medications, ADRA2C-targeted treatments can have side effects. Some of the potential side effects associated with these treatments include changes in heart rate and blood pressure, sleep disturbances, gastrointestinal issues, and changes in mood or behavior. The specific side effects will depend on the type of treatment and the individual patient.

Are there any potential side effects associated with ADRA2C-targeted treatments? 01/01/2017

Like any medication, there is the potential for side effects with ADRA2C-targeted treatments. Common side effects may include dizziness, headaches, constipation, and dry mouth. Some patients may also experience changes in heart rate or blood pressure, particularly if they are taking other medications that impact the adrenergic system.

Are there any lifestyle changes that can help regulate ADRA2C function? 11/02/2016

While medication is often necessary for patients with adrenergic dysfunction, there are also lifestyle changes that can help regulate ADRA2C function and improve overall health. For example, maintaining a healthy diet, getting regular exercise, reducing stress, and avoiding tobacco and excessive alcohol consumption may all have a positive impact on the adrenergic system. Additionally, regular sleep patterns and good sleep hygiene may improve overall adrenergic regulation.

How does ADRA2C dysfunction relate to mental health conditions? 09/01/2016

ADRA2C dysfunction has been linked to several mental health conditions, including depression, anxiety, and attention-deficit/hyperactivity disorder (ADHD). Research suggests that alterations in adrenergic function, including changes in ADRA2C levels and activity, may play a role in the development and progression of these conditions. Targeting ADRA2C with medication may therefore be a promising treatment approach for individuals with these conditions.

What are some research studies being conducted on ADRA2C proteins? 07/14/2016

Many researchers are currently studying ADRA2C proteins and their potential role in various medical conditions. Some studies are focused on developing new drugs that can selectively target and regulate ADRA2C function, while others are exploring the genetic and environmental factors that influence ADRA2C regulation and function.

What are some of the medical conditions that can be associated with ADRA2C dysfunction? 03/31/2016

Adrenergic dysfunction has been associated with several medical conditions, including hypertension, anxiety disorders, depression, and attention deficit hyperactivity disorder (ADHD). The precise role that ADRA2C proteins play in these conditions can vary, and more research is needed to fully understand their function.

How can lifestyle changes and natural remedies influence ADRA2C function? 01/05/2016

Lifestyle changes, such as regular exercise, stress reduction techniques, and a healthy diet, may help regulate ADRA2C function by reducing stress and promoting overall physical and mental health. Natural remedies, such as herbal supplements, may also be beneficial in some cases. However, more research is needed to fully understand the effects of these practices on ADRA2C function.

Customer Reviews (5)

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Reviews
01/09/2021

    The manufacturer's technical support team is incredibly efficient and capable of addressing any concerns or issues that may arise during the process.

    02/28/2020

      The manufacturer has also demonstrated a keen understanding of my needs and has gone above and beyond to provide me with excellent technical support, which has proven to be invaluable in helping me navigate any potential obstacles that may arise.

      08/28/2019

        Based on my analysis, I can confidently affirm that the protein in question exhibits a remarkable level of quality that makes it ideal for fulfilling the requirements of my experiments.

        01/05/2018

          I am confident that utilizing this protein will enable me to achieve precise and consistent results and meet my research objectives effectively.

          07/29/2017

            the level of consistency and purity exhibited by the protein is truly exceptional, providing me with the confidence that my experiments will yield results that are both accurate and reliable.

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