ADRB3A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | ADRB3A-6848Z | Recombinant Zebrafish ADRB3A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ADRB3A involved in several pathways and played different roles in them. We selected most pathways ADRB3A participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRB3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Calcium signaling pathway | GNA14;PRKCBA;ITPR1;CHRM5A;PTGER1A;HTR2CL1;HTR7;PLN;ADRA1D |
Neuroactive ligand-receptor interaction | PTGFR;LOC780933;S1PR2;CCKBR;P2RX3A;AGTR1A;GCGR;MTNR1A;HTR1B |
Endocytosis | RUFY1;PIP5KL1;LDLRAP1B;GBF1;ASAP1;PIP5K1A;PARD6B;VPS35;EGFRA |
Adrenergic signaling in cardiomyocytes | MYL3;TNNC1A;ADCY1A;MAPK12A;CREB3L3A;AKT2;RYR2;CREB3L2;CREB3L3 |
Gap junction | GNA11A;TUBB2A;TUBA1A;HTR2B;MAP2K2A;TUBA8L2;ADRB3B;RAF1B;GUCY1B3 |
ADRB3A has several biochemical functions, for example, G-protein coupled receptor activity, beta3-adrenergic receptor activity, epinephrine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB3A itself. We selected most functions ADRB3A had, and list some proteins which have the same functions with ADRB3A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
G-protein coupled receptor activity | OXTRL;GPR124;OLFR473;ZFPM2B;GPR161;OR7D2;OR4C12;TAAR6;OXGR1A.1 |
beta3-adrenergic receptor activity | ADRB3A;ADRB3B;ADRB3 |
epinephrine binding | ADRB2;ADRA2C;ADRB2A;ADRB3;ADRA2A;ADRB2B;ADRB3B;ADRB3A;ADRA2B |
norepinephrine binding | ADRB3B;ADRB2;ADRB1;ADRA2A;ADRB3A |
signal transducer activity | C18orf32;ADRB2B;OPN4XA;PLCXD3;PTGER4C;GNAL;GNAZ;OLFR8;TAAR10D |
ADRB3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRB3A here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRB3A.
- Q&As
- Reviews
Q&As (14)
Ask a questionADRB3A receptors are primarily located in adipose tissue, where they play a role in promoting lipolysis (the breakdown of stored fat). When these receptors are activated, they stimulate the release of fatty acids from adipose tissue, which can be used by the body for energy.
ADRB3A-targeted therapies can have side effects, such as nausea, vomiting, diarrhea, and urinary tract issues. They can also increase heart rate and blood pressure, potentially leading to cardiovascular complications. Additionally, long-term use of these therapies can lead to a decrease in the number of receptors, leading to decreased efficacy and potential tolerance.
ADRB3A proteins can be targeted in medical treatments through the use of medications known as beta-3 adrenergic receptor agonists or antagonists. Agonists can activate ADRB3A proteins to increase fat burning and energy expenditure, while antagonists can block the activity of these proteins to reduce glucose uptake and insulin secretion.
ADRB3A-targeted therapies are generally considered safe, but some potential side effects may include increased heart rate, blood pressure, and metabolic rate. These effects may be more pronounced in individuals with cardiovascular disease or other underlying health conditions.
ADRB3A proteins have been implicated in the metabolic response to exercise, particularly with regard to the increase in fat burning and energy expenditure that occurs during physical activity. Some studies suggest that exercise training can increase the expression of ADRB3A in muscle tissue, leading to improved metabolic function and insulin sensitivity.
Some of the challenges associated with developing ADRB3A-targeted therapies include achieving selectivity and specificity, determining the optimal dose and treatment duration, and ensuring long-term safety and efficacy in diverse patient populations.
ADRB3A proteins have been studied for their potential role in cancer development and treatment, as they have been found to be expressed in various types of cancer cells. However, the role of ADRB3A in cancer is complex, and there is not enough evidence to support the use of ADRB3A-targeted therapies for cancer treatment at this time.
ADRB3A receptors are involved in regulating glucose metabolism, particularly in adipose tissue and skeletal muscle. When activated, ADRB3A receptors promote glucose uptake and utilization in these tissues, potentially leading to improved glucose tolerance and insulin sensitivity.
Activation of ADRB3A proteins in pancreatic beta cells can stimulate insulin secretion and improve glucose metabolism, suggesting their potential use in treating type 2 diabetes. However, further research is needed to determine the safety and effectiveness of targeting ADRB3A proteins in diabetes management.
Yes, several genetic variations (polymorphisms) in the ADRB3A gene have been associated with increased risk of obesity, diabetes, and cardiovascular disease. These variations may affect the function and expression of ADRB3A, leading to altered metabolic and physiological responses.
ADRB3A-targeted therapies have been explored as a potential treatment for type 2 diabetes, as they may improve insulin sensitivity and glucose metabolism. However, there are currently no approved drugs that specifically target ADRB3A for the treatment of diabetes.
ADRB3A proteins have been associated with various medical conditions, including obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Polymorphisms in the ADRB3 gene have also been linked to an increased risk of these conditions.
The activation of ADRB3A proteins has been studied for its potential effect on weight loss and obesity management. However, results have been mixed, and the long-term safety and efficacy of using ADRB3A agonists for weight loss are still uncertain.
ADRB3A proteins are not commonly used in the treatment of asthma, as they primarily play a role in metabolism and energy expenditure rather than airway constriction. The primary target of asthma treatment is the bronchial smooth muscle, which is targeted by medications such as bronchodilators.
Customer Reviews (4)
Write a reviewThe technical support provided by the manufacturer is also exceptional.
The protein is free of any impurities, which often cause unwanted variability in results, and the stability ensures that the protein remains active throughout the duration of my experiments.
the purity and stability of the ADRB3A protein provided by the manufacturer are critical factors that contribute to the success of my experiments.
I am confident that utilizing the ADRB3A protein and the manufacturer's technical support will yield significant advancements in the field of metabolic research and contribute to the development of new and effective treatments for metabolic disorders.
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