AFF3
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Official Full Name
AF4/FMR2 family, member 3
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Overview
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. -
Synonyms
AFF3; AF4/FMR2 family, member 3; LAF4, lymphoid nuclear protein related to AF4; AF4/FMR2 family member 3; MLLT2 like; protein LAF-4; MLLT2-related protein; lymphoid nuclear protein 4; lymphoid nuclear protein related to AF4; LAF4; MLLT2-like;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AFF3-3232H | Recombinant Human AFF3, His-tagged | E.Coli or Yeast | His | 1251 | |
Mouse | Aff3-3233M | Recombinant Mouse Aff3, His-tagged | E.Coli or Yeast | His | 1254 |
- Involved Pathway
- Protein Function
- Interacting Protein
- AFF3 Related Articles
AFF3 involved in several pathways and played different roles in them. We selected most pathways AFF3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AFF3 has several biochemical functions, for example, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF3 itself. We selected most functions AFF3 had, and list some proteins which have the same functions with AFF3. You can find most of the proteins on our site.
Function | Related Protein |
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double-stranded DNA binding | AFF3;FEV;NTHL1;GTF2H4;CGGBP1;SATB1;TARDBP;CRY1;HNRNPDL |
AFF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF3.
CDK9
- Q&As
- Reviews
Q&As (10)
Ask a questionVarious experimental techniques or assays, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches, have been used to study the functional significance of AFF3 protein.
The expression of AFF3 protein is regulated by specific factors and signaling pathways.
Dysregulation or dysfunction of AFF3 protein can affect transcriptional regulation, perturb gene expression networks, and contribute to disease development.
AFF3 protein holds potential as a target for modulating gene expression or disease phenotypes, and further research is needed to explore its implications for therapeutic interventions.
AFF3 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.
AFF3 protein contributes to cellular processes such as development, differentiation, or disease progression, and the underlying molecular mechanisms are currently being investigated.
AFF3 protein plays a role in gene transcription or chromatin remodeling, and its function can be investigated using techniques like chromatin immunoprecipitation or gene expression analysis.
Genetic variations or mutations in the gene encoding AFF3 protein may impact its expression or function, influencing cellular processes or disease susceptibility.
The subcellular localization of AFF3 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.
Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF3 protein.
Customer Reviews (3)
Write a reviewElucidating protein-protein interactions in chromatin modifications for gene regulation.
Exploring protein-protein interactions in epigenetic regulation for cellular memory.
Unraveling protein-protein interactions in DNA replication for genome duplication.
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