Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

AFF3

  • Official Full Name

    AF4/FMR2 family, member 3

  • Overview

    This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
  • Synonyms

    AFF3; AF4/FMR2 family, member 3; LAF4, lymphoid nuclear protein related to AF4; AF4/FMR2 family member 3; MLLT2 like; protein LAF-4; MLLT2-related protein; lymphoid nuclear protein 4; lymphoid nuclear protein related to AF4; LAF4; MLLT2-like;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AFF3-3232H Recombinant Human AFF3, His-tagged E.Coli or Yeast His 1251
Mouse Aff3-3233M Recombinant Mouse Aff3, His-tagged E.Coli or Yeast His 1254
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AFF3 Related Articles

AFF3 involved in several pathways and played different roles in them. We selected most pathways AFF3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AFF3 has several biochemical functions, for example, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF3 itself. We selected most functions AFF3 had, and list some proteins which have the same functions with AFF3. You can find most of the proteins on our site.

Function Related Protein
double-stranded DNA bindingAFF3;FEV;NTHL1;GTF2H4;CGGBP1;SATB1;TARDBP;CRY1;HNRNPDL

AFF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF3.

CDK9

Viatte, S; Plant, D; et al. Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients. ANNALS OF THE RHEUMATIC DISEASES 71:1984-1990(2012).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What experimental techniques or assays have been used to study the functional significance of AFF3 protein, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches? 05/18/2020

Various experimental techniques or assays, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches, have been used to study the functional significance of AFF3 protein.

How is the expression of AFF3 protein regulated, and what factors or signaling pathways control its expression? 09/20/2019

The expression of AFF3 protein is regulated by specific factors and signaling pathways.

How does dysregulation or dysfunction of AFF3 protein affect transcriptional regulation, gene expression networks, or disease development? 06/17/2019

Dysregulation or dysfunction of AFF3 protein can affect transcriptional regulation, perturb gene expression networks, and contribute to disease development.

Can AFF3 protein be targeted or manipulated to modulate gene expression or disease phenotypes, and what are the potential implications for therapeutic interventions? 10/01/2018

AFF3 protein holds potential as a target for modulating gene expression or disease phenotypes, and further research is needed to explore its implications for therapeutic interventions.

Does AFF3 protein interact with specific molecules or participate in protein complexes, and what are the functional implications of these interactions? 05/30/2018

AFF3 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.

How does AFF3 protein contribute to cellular processes such as development, differentiation, or disease progression, and what are the underlying molecular mechanisms? 04/29/2018

AFF3 protein contributes to cellular processes such as development, differentiation, or disease progression, and the underlying molecular mechanisms are currently being investigated.

What is the role of AFF3 protein in gene transcription or chromatin remodeling, and how can its function be investigated experimentally? 11/26/2017

AFF3 protein plays a role in gene transcription or chromatin remodeling, and its function can be investigated using techniques like chromatin immunoprecipitation or gene expression analysis.

Are there any genetic variations or mutations in the gene encoding AFF3 protein that impact its expression or function, and what are the implications for cellular processes or disease susceptibility? 04/20/2017

Genetic variations or mutations in the gene encoding AFF3 protein may impact its expression or function, influencing cellular processes or disease susceptibility.

What is the subcellular localization of AFF3 protein, and how can it be experimentally determined? 02/01/2016

The subcellular localization of AFF3 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.

Are there any known post-translational modifications or regulatory mechanisms that modulate the activity or stability of AFF3 protein? 09/22/2015

Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF3 protein.

Customer Reviews (3)

Write a review
Reviews
11/01/2021

    Elucidating protein-protein interactions in chromatin modifications for gene regulation.

    05/09/2019

      Exploring protein-protein interactions in epigenetic regulation for cellular memory.

      04/04/2019

        Unraveling protein-protein interactions in DNA replication for genome duplication.

        Ask a Question for All AFF3 Products

        Required fields are marked with *

        My Review for All AFF3 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends