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AFF4

  • Official Full Name

    AF4/FMR2 family, member 4

  • Overview

    The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23).
  • Synonyms

    AFF4; AF4/FMR2 family, member 4; AF4/FMR2 family member 4; AF5Q31; ALL1 fused gene from 5q31; MCEF; ALL1-fused gene from chromosome 5q31 protein; major CDK9 elongation factor-associated protein; MGC75036;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AFF4-696H Recombinant Human AFF4 Mammalian Cell His
Human AFF4-407H Recombinant Human AFF4 Protein, GST-tagged Wheat Germ GST
Human AFF4-9457H Recombinant Human AFF4, His-tagged E.coli His 1-338a.a.
Human AFF4-8988HCL Recombinant Human AFF4 293 Cell Lysate HEK293 N/A
Human AFF4-989HF Recombinant Full Length Human AFF4 Protein, GST-tagged In Vitro Cell Free System GST 365 amino acids
Human AFF4-2439H-B Recombinant Human AFF4 Protein Pre-coupled Magnetic Beads HEK293
Human AFF4-2439H Recombinant Human AFF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AFF4 Related Articles

AFF4 involved in several pathways and played different roles in them. We selected most pathways AFF4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AFF4 has several biochemical functions, for example, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF4 itself. We selected most functions AFF4 had, and list some proteins which have the same functions with AFF4. You can find most of the proteins on our site.

Function Related Protein
protein bindingRYR2;ZNF397;CAV1;NR4A1;COL4A3BP;COPB1;AATF;JDP2;RSPH9
transcription factor activity, sequence-specific DNA bindingZNF8;HSFX1;FOXD3;NR1I3;HIF1AB;ATOH8;TFE3;NR3C1;SMAD6A

AFF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF4.

CDK9; CCNT1; MLLT1

Liu, PY; Xiang, YH; et al. Release of Positive Transcription Elongation Factor b(P-TEFb)from 7SK Small Nuclear Ribonucleoprotein ( snRNP) Activates Hexamethylene Bisacetamide- inducible Protein ( HEXIM1) Transcription*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:9918-9925(2014).
Lu, HS; Li, ZC; et al. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E15-E24(2014).
  • Q&As
  • Reviews

Q&As (10)

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What is the subcellular localization of AFF4 protein, and how can it be experimentally determined? 11/23/2020

The subcellular localization of AFF4 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.

How is the expression of AFF4 protein regulated, and what factors or signaling pathways control its expression? 11/15/2019

The expression of AFF4 protein is regulated by specific factors and signaling pathways.

What experimental techniques or assays have been used to study the functional significance of AFF4 protein, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches? 08/19/2019

Various experimental techniques or assays, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches, have been used to study the functional significance of AFF4 protein.

Does AFF4 protein interact with specific molecules or participate in protein complexes, and what are the functional implications of these interactions? 06/22/2019

AFF4 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.

Are there any known post-translational modifications or regulatory mechanisms that modulate the activity or stability of AFF4 protein? 05/29/2019

Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF4 protein.

Are there any genetic variations or mutations in the gene encoding AFF4 protein that impact its expression or function, and what are the implications for cellular processes or disease susceptibility? 07/09/2018

Genetic variations or mutations in the gene encoding AFF4 protein may impact its expression or function, influencing cellular processes or disease susceptibility.

How does dysregulation or dysfunction of AFF4 protein affect transcriptional regulation, gene expression networks, or disease development? 01/27/2018

Dysregulation or dysfunction of AFF4 protein can affect transcriptional regulation, perturb gene expression networks, and contribute to disease development.

How does AFF4 protein contribute to specific cellular processes such as development, differentiation, or disease progression, and what are the underlying molecular mechanisms? 03/29/2017

AFF4 protein contributes to specific cellular processes such as development, differentiation, or disease progression, and the underlying molecular mechanisms are currently being investigated.

Can AFF4 protein be targeted or manipulated to modulate gene expression or disease phenotypes, and what are the potential implications for therapeutic interventions? 03/05/2017

AFF4 protein holds potential as a target for modulating gene expression or disease phenotypes, and further research is needed to explore its implications for therapeutic interventions.

What is the role of AFF4 protein in transcriptional elongation or chromatin remodeling, and how can its function be investigated experimentally? 08/20/2015

AFF4 protein plays a role in transcriptional elongation or chromatin remodeling, and its function can be investigated using techniques like chromatin immunoprecipitation or gene expression analysis.

Customer Reviews (3)

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Reviews
10/12/2021

    Investigating protein-protein interactions in cellular metabolism for energy balance.

    03/08/2020

      Studying protein-protein interactions in cell migration for tissue morphogenesis.

      07/24/2017

        Mapping protein-protein interactions in receptor trafficking for cellular signaling.

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