AFF4
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Official Full Name
AF4/FMR2 family, member 4
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Overview
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). -
Synonyms
AFF4; AF4/FMR2 family, member 4; AF4/FMR2 family member 4; AF5Q31; ALL1 fused gene from 5q31; MCEF; ALL1-fused gene from chromosome 5q31 protein; major CDK9 elongation factor-associated protein; MGC75036;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AFF4-696H | Recombinant Human AFF4 | Mammalian Cell | His | ||
Human | AFF4-407H | Recombinant Human AFF4 Protein, GST-tagged | Wheat Germ | GST | ||
Human | AFF4-9457H | Recombinant Human AFF4, His-tagged | E.coli | His | 1-338a.a. | |
Human | AFF4-8988HCL | Recombinant Human AFF4 293 Cell Lysate | HEK293 | N/A | ||
Human | AFF4-989HF | Recombinant Full Length Human AFF4 Protein, GST-tagged | In Vitro Cell Free System | GST | 365 amino acids | |
Human | AFF4-2439H-B | Recombinant Human AFF4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | AFF4-2439H | Recombinant Human AFF4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
- AFF4 Related Articles
AFF4 involved in several pathways and played different roles in them. We selected most pathways AFF4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AFF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AFF4 has several biochemical functions, for example, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFF4 itself. We selected most functions AFF4 had, and list some proteins which have the same functions with AFF4. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | RYR2;ZNF397;CAV1;NR4A1;COL4A3BP;COPB1;AATF;JDP2;RSPH9 |
transcription factor activity, sequence-specific DNA binding | ZNF8;HSFX1;FOXD3;NR1I3;HIF1AB;ATOH8;TFE3;NR3C1;SMAD6A |
AFF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AFF4.
CDK9; CCNT1; MLLT1
- Q&As
- Reviews
Q&As (10)
Ask a questionThe subcellular localization of AFF4 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.
The expression of AFF4 protein is regulated by specific factors and signaling pathways.
Various experimental techniques or assays, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches, have been used to study the functional significance of AFF4 protein.
AFF4 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.
Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF4 protein.
Genetic variations or mutations in the gene encoding AFF4 protein may impact its expression or function, influencing cellular processes or disease susceptibility.
Dysregulation or dysfunction of AFF4 protein can affect transcriptional regulation, perturb gene expression networks, and contribute to disease development.
AFF4 protein contributes to specific cellular processes such as development, differentiation, or disease progression, and the underlying molecular mechanisms are currently being investigated.
AFF4 protein holds potential as a target for modulating gene expression or disease phenotypes, and further research is needed to explore its implications for therapeutic interventions.
AFF4 protein plays a role in transcriptional elongation or chromatin remodeling, and its function can be investigated using techniques like chromatin immunoprecipitation or gene expression analysis.
Customer Reviews (3)
Write a reviewInvestigating protein-protein interactions in cellular metabolism for energy balance.
Studying protein-protein interactions in cell migration for tissue morphogenesis.
Mapping protein-protein interactions in receptor trafficking for cellular signaling.
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