Recombinant Full Length Human AFF4 Protein, GST-tagged

• Cat.No.: AFF4-989HF
• Product Overview: Human AFF4 full-length ORF ( AAH25700.1, 1 a.a. - 365 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 66.6 kDa
• Protein Length: 365 amino acids
• AA Sequence: MNREDRNVLR MKERERRNQE IQQGEDAFPP SSPLFAEPYK VTSKEDKLSS RIQSMLGNYD EMKDFIGDRS IPKLVAIPKP TVPPSADEKS NPNFFEQRHG GSHQSSKWTP VGPAPSTSQS QKRSSGLQSG HSSQRTSAGS SSGTNSSGQR HDRESYNNSG SSSRKKGQHG SEHSKSRSSS PGKPQAVSSL NSSHSRSHGN DHHSKEHQRS KSPRDPDANW DSPSRVPFSS GQHSTQSFPP SLMSKSNSML QKPTAYVRPM DGQESMEPKL SSEHYSSQSH GNSMTELKPS SKAHLTKLKI PSQPLDASAS GDVSCVDEIL KEMTHSWPPP LTAIHTPCKT EPSKFPFPTK ESQQSNFGTG EQRLK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AFF4 AF4/FMR2 family, member 4 [ Homo sapiens ]
• Official Symbol: AFF4
• Synonyms: AFF4; AF4/FMR2 family, member 4; AF4/FMR2 family member 4; AF5Q31; ALL1 fused gene from 5q31; MCEF; ALL1-fused gene from chromosome 5q31 protein; major CDK9 elongation factor-associated protein; MGC75036
• Gene ID: 27125
• mRNA Refseq: NM_014423
• Protein Refseq: NP_055238
• MIM: 604417
• UniProt ID: Q9UHB7