• Official Full Name


  • Overview

    Alpha-2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure.
  • Synonyms

    AHSG; alpha-2-HS-glycoprotein; AHS; A2HS; HSGA; FETUA; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-A; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; PRO2743; OTTHUMP00000210158; OTTHUMP00000210159;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Bovine
  • Cattle
  • Guinea pig
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Pig
  • Rat
  • Bovine
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • human plasma
  • Human plasma
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AHSG-469H Active Recombinant Human AHSG Protein HEK293 N/A
Human AHSG-4356H Recombinant Human Alpha-2-HS-Glycoprotein Human N/A
Human AHSG-704H Recombinant Human AHSG protein, His-tagged HEK293 His
Human AHSG-7710H Recombinant Human AHSG protein, His-tagged HEK293 His
Human AHSG-202H Recombinant Human AHSG protein, T7/His-tagged E.coli T7/His
Human AHSG-565H Recombinant Human alpha-2-HS-glycoprotein, His-tagged E.coli His
Human AHSG-470H Recombinant Human AHSG Protein, GST-tagged Wheat Germ GST
Human AHSG-165H Recombinant Human AHSG Protein, His-tagged E.coli His
Human AHSG-166H Recombinant Human AHSG Protein, His/GST-tagged E.coli His/GST
Human AHSG-2958HCL Recombinant Human AHSG cell lysate Human Cell N/A
Human AHSG-160HG GMP Recombinant Human AHSG protein HEK293
Human AHSG-446HFL Recombinant Full Length Human AHSG Protein, C-Flag-tagged Mammalian cells Flag
Human AHSG-1001H Human Leucine-rich Alpha-2-glycoprotein 1 human plasma N/A
Human AHSG-0312H Recombinant Human AHSG Protein (Ala19-Val367), N-His-tagged E.coli N-His
Human AHSG-0314H Recombinant Human AHSG Protein (Ala19-Leu300), N-His-tagged E.coli N-His
Human AHSG-816H Recombinant Human AHSG Protein HEK293
Human AHSG-111H Native Human Alpha 2 HS Glycoprotein Human plasma N/A
Human AHSG-952HF Recombinant Full Length Human AHSG Protein, GST-tagged In Vitro Cell Free System GST
Human AHSG-2173H Recombinant Human AHSG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AHSG-3000H Recombinant Human AHSG Protein (Cys16-Pro382), C-His tagged Mammalian cells C-His
Human AHSG-298H Recombinant Human AHSG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AHSG-2701H Active Recombinant Human AHSG protein, His-tagged HEK293 His
Human AHSG-298H-B Recombinant Human AHSG Protein Pre-coupled Magnetic Beads HEK293
Mouse Ahsg-674M Active Recombinant Mouse Ahsg Protein, His-tagged Mammalian cells His
Mouse Ahsg-705M Active Recombinant Mouse Ahsg protein(Met1-Ile345), His-tagged HEK293 C-His
Mouse Ahsg-92M Recombinant Mouse Ahsg, His-tagged Insect Cell His
Mouse Ahsg-167M Recombinant Mouse Ahsg Protein, His-tagged E.coli His
Mouse AHSG-2957MCL Recombinant Mouse AHSG cell lysate Human Cell N/A
Mouse Ahsg-7155M Recombinant Mouse Ahsg Protein, His-tagged Insect Cell His
Mouse Ahsg-557M Recombinant Mouse Ahsg Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Ahsg-408M-B Recombinant Mouse Ahsg Protein Pre-coupled Magnetic Beads HEK293
Mouse Ahsg-408M Recombinant Mouse Ahsg Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat aHSG-3325R Recombinant Rat aHSG, His-tagged E.coli His
Rat Ahsg-168R Recombinant Rat Ahsg Protein, His-tagged E.coli His
Rat AHSG-574R Recombinant Rat AHSG Protein Mammalian Cell His
Rat AHSG-230R Recombinant Rat AHSG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AHSG-230R-B Recombinant Rat AHSG Protein Pre-coupled Magnetic Beads HEK293
Bovine AHSG-331BI Immobilized Bovine AHSG protein Bovine N/A
Cattle AHSG-101C Recombinant Cattle AHSG Protein, His-tagged E.coli N-His
Guinea pig Ahsg-102G Recombinant Guinea pig Ahsg Protein, His-tagged E.coli N-His
Macaca mulatta (Rhesus macaque) AHSG-5596M Recombinant Rhesus macaque AHSG Protein (Ala19-Val367), C-His tagged Mammalian cells C-His
Pig AHSG-103P Recombinant Pig AHSG Protein, His-tagged E.coli N-His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AHSG Related Articles
  • AHSG Related Research Area

AHSG involved in several pathways and played different roles in them. We selected most pathways AHSG participated on our site, such as BMP receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHSG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AHSG has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AHSG itself. We selected most functions AHSG had, and list some proteins which have the same functions with AHSG. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase inhibitor activityCST14B.1;SPOCK1;CARD17;CSTA;CST5;NLRC4;NGP;NAIP1;CST1
endopeptidase inhibitor activityC3A.2;ITIH2;RECK;USP14;SERPIND1;SERPINA1A;SERPINA1E;SERPINF2;A1i3
kinase inhibitor activityAHSG;SOCS1;RHOH;LRP6

AHSG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHSG here. Most of them are supplied by our site. Hope this information will be useful for your research of AHSG.

Hsd17b7; ABL1; Smad3; Mad2l1; AKT1; CDC42; GRB2; d-mannose; ALB; ATF2

Fernandez-Grijalva, AL; Aguilar-Lemarroy, A; et al. Alpha 2HS-glycoprotein, a tumor-associated antigen (TAA) detected in Mexican patients with early-stage breast cancer. JOURNAL OF PROTEOMICS 112:301-312(2015).
Biswas, S; Sharma, S; et al. Identification of Novel Autoantigen in the Synovial Fluid of Rheumatoid Arthritis Patients Using an Immunoproteomics Approach. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How can proteomics approaches be used to study the protein-protein interactions involving AHSG in a global context? 08/14/2022

Techniques like co-immunoprecipitation coupled with mass spectrometry can reveal AHSG's interactome, shedding light on its broader functional networks.

Explain the potential diagnostic applications of AHSG in conditions such as chronic kidney disease and diabetes? 07/09/2022

AHSG levels may be altered in these conditions, making it a potential biomarker for disease progression or severity.

Explain the potential role of AHSG in mediating endocrine functions and its connection to insulin resistance? 12/31/2021

AHSG's interaction with insulin and adipokines could impact insulin sensitivity and metabolism, contributing to insulin resistance in conditions like type 2 diabetes.

Discuss the interactions between AHSG and other proteins, particularly its relationship with fetuin-B and fetuin-A? 06/11/2021

AHSG can form complexes with fetuin-B and fetuin-A, which have implications for calcium homeostasis, insulin signaling, and other physiological processes.

Explain AHSG's role in modulating immune responses and its potential relevance to autoimmune disorders? 08/02/2020

AHSG can interact with immune cells and cytokines, potentially influencing immune responses. Dysregulated AHSG levels might contribute to autoimmune diseases.

How might AHSG's interactions with circulating proteins influence its functions and its potential clinical relevance? 02/19/2020

AHSG's interactions with proteins like albumin and hormones can impact its bioavailability and activity, influencing physiological processes.

Describe the biochemical methods used to analyze AHSG's post-translational modifications, including glycosylation. 06/13/2019

Techniques such as mass spectrometry, lectin affinity chromatography, and glycan analysis can provide insights into AHSG's glycosylation patterns.

How does AHSG regulate calcium homeostasis, and what implications does this have for human health? 03/22/2019

AHSG binds to calcium ions and influences their distribution in the body. Dysregulation may impact bone health and contribute to conditions like osteoporosis.

How can researchers isolate and purify AHSG for biochemical studies in the laboratory? 10/28/2018

Techniques such as ion exchange chromatography, gel filtration, and affinity chromatography can be used to isolate and purify AHSG from biological samples.

How might genetic variations in the AHSG gene impact its protein expression and functions? 05/04/2018

Genetic polymorphisms in the AHSG gene might lead to altered AHSG levels or structural changes, potentially influencing its physiological roles.

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