AK8

  • Official Full Name

    adenylate kinase 8

  • Overview

    Adenylate kinase (EC 2.7.4.3) (also known as ADK or myokinase) is a phosphotransferase enzyme that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy homeostasis.

  • Synonyms

    DDX31;C9orf98;FLJ32704;FLJ36014;RP11-143F18.1;adenylate kinase 8;OTTHUMP00000022737;putative adenylate kinase-like protein C9orf98

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Cynomolgus
  • Rat
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc

    Involved Pathway

    AK8 involved in several pathways and played different roles in them. We selected most pathways AK8 participated on our site, such as Biosynthesis of antibiotics,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biosynthesis of antibiotics GALM,ADSL,CYP51A1,GLYCTK,EHHADH,AMDHD2,UAP1L1,ADH5,CS,ANI_1_2390104
    Metabolic pathways GALNS,NT5C2,HYAL6,HYKK.2,GUK1A,GGT7,GBA,PNAT3,CYP4F14,AMPD2
    Metabolism SLC16A1,ADSL,PDP2,NUDT18,SULT4A1,LPA,SULT1ST6,AKR1C21,CKB,ALOX5B.2
    Metabolism of nucleotides DUT,GRX2,AK7A,NUDT16,TYMP,DPYDA.1,DCK,GLRX,ADSL,PAICS
    purine nucleotides de novo biosynthesis ADSSL1,ATP5S,AK7
    adenosine ribonucleotides de novo biosynthesis ADSSL1,ATP5S,AK7,ADSS,ATP5L
    Purine metabolism GUCY2E,CANT1A,PRIM2,CANT1,ENPP3,TM9SF1,NME5,POLE,PAPSS2,URAD
    Synthesis and interconversion of nucleotide di- and triphosphates GRX2,AK7A,DTYMK,AK7,GLRX

    Protein Function

    AK8 has several biochemical functions, for example, ATP binding,adenylate kinase activity,cytidylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK8 itself. We selected most functions AK8 had, and list some proteins which have the same functions with AK8. You can find most of the proteins on our site.

    Function Related Protein
    nucleoside diphosphate kinase activity NME7,CMPK1,NME2B.1,NME2A,TXNDC3,NME2B.2,AK1,NME1,CMPK2,NME4
    adenylate kinase activity AK2,AK1,AK5,AK4,AK7
    protein binding GLI2,VHL,PAF1,SPOP,RPS6KA3,SNX4,IGF2R,NOS1,PRKAA2,AP1M2
    ATP binding CARKD,DHX8,BRAF,UBE2H,GRK4,MAPK12,CAMK2D,BLM,MOV10,MAPK14A
    cytidylate kinase activity CMPK,CMPK2,CMPK1,AK7

    Interacting Protein

    AK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK8.

    CCDC102B;MCM7;MAP3K7CL;RBM39;RBM39;HAUS1;ZMAT2

    Resources

    References

    • Grueb, M; Rohrbach, JM; et al. Serotonin (5-HT7) Receptor-Stimulated Activation of cAMP-PKA Pathway in Bovine Corneal Epithelial and Endothelial Cells. OPHTHALMIC RESEARCH 48:22-27(2012).
    • Moteki, H; Kimura, M; et al. Activation of Extracellular-Signal Regulated Kinase by Epidermal Growth Factor Is Potentiated by cAMP-Elevating Agents in Primary Cultures of Adult Rat Hepatocytes. BIOLOGICAL & PHARMACEUTICAL BULLETIN 34:1542-1552(2011).

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