AKR1B1

  • Official Full Name

    aldo-keto reductase family 1, member B1 (aldose reductase)

  • Overview

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
  • Synonyms

    AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase); AR; ADR; ALR2; ALDR1; aldose reductase; aldehyde reductase 1; low Km aldose reductase; Lii5-2 CTCL tumor antigen; aldo-keto reductase family 1 member B1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKR1B1-136H Active Recombinant Human AKR1B1 protein E.coli N/A
Human AKR1B1-2496H Recombinant Human AKR1B1 protein(Met1-Phe316), His-tagged E.coli N-His Met1-Phe316
Human AKR1B1-9156H Active Recombinant Human AKR1B1, His-tagged E.coli His
Human AKR1B1-409H Recombinant Human AKR1B1 Protein, GST-tagged Wheat Germ GST
Human AKR1B1-47HCL Recombinant Human AKR1B1 cell lysate N/A
Human AKR1B1-1363HF Recombinant Full Length Human AKR1B1 Protein, GST-tagged In Vitro Cell Free System GST 316 amino acids
Human AKR1B1-3168H Recombinant Human AKR1B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKR1B1-1219H Recombinant Human AKR1B1 protein, GST-tagged E.coli GST 1-316 aa
Human AKR1B1-304H-B Recombinant Human AKR1B1 Protein Pre-coupled Magnetic Beads HEK293
Human AKR1B1-304H Recombinant Human AKR1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AKR1B1-1172HFL Recombinant Full Length Human AKR1B1 Protein, C-Flag-tagged Mammalian cells Flag
Human AKR1B1-2656H Recombinant Human AKR1B1 protein(11-290 aa), C-His-tagged E.coli C-His 11-290 aa
Rat AKR1B1-596R Recombinant Rat AKR1B1 Protein Mammalian Cell His
Rat Akr1b1-3269R Recombinant Rat Akr1b1, His-tagged E.Coli or Yeast His 316
Rat AKR1B1-252R-B Recombinant Rat AKR1B1 Protein Pre-coupled Magnetic Beads HEK293
Rat AKR1B1-252R Recombinant Rat AKR1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AKR1B1-292R Recombinant Rhesus monkey AKR1B1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AKR1B1-120R Recombinant Rhesus Macaque AKR1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AKR1B1-120R-B Recombinant Rhesus Macaque AKR1B1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish AKR1B1-283Z Recombinant Zebrafish AKR1B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AKR1B1 involved in several pathways and played different roles in them. We selected most pathways AKR1B1 participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsKL;RPE;UGT1A6;UGT1A7;UGT2A2;UGT1AB;XYLB;AKR1B1;DHDHL
Fructose and mannose metabolismAKR1B1L;FPGT;FBP1B;PFKP;PFKL;AKR1B8;TPI1;GMPPB;PFKM
Galactose metabolismG6PCA.1;PFKMA;PFKM;G6PCA.2;AKR1B10;GANC;B4GALT2;HK3;PFKP
Glycerolipid metabolismALDH2;ALDH2.1;ALDH9A1;PNLIPRP1;MOGAT3A;TAE1;PNLIP;glpK;CELL
Metabolic pathwaysNOS2;B4GALT6;COMTA;CHIA.2;SDHB;MTMR7A;IMPDH2;ENO1;GFPT1

AKR1B1 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1B1 itself. We selected most functions AKR1B1 had, and list some proteins which have the same functions with AKR1B1. You can find most of the proteins on our site.

Function Related Protein
alditol:NADP+ 1-oxidoreductase activityAKR1C3;AKR1B7;PRKRA;AKR1B1;Akr1b3;AKR1C21;AKR1B8;AKR7A5;AKR7A2
aldo-keto reductase (NADP) activityAKR7A3;KCNAB2;AKR1B10;KCNAB1;AKR1C6;HSD3B6;MIOX;SPR;CYB5A
electron carrier activityCYCSB;PHGDH;ACADL;ACAD11;GRXCR1;ACADSB;PTGESL;ETFA;AOC2
glyceraldehyde oxidoreductase activityAKR1B1;Akr1b3

AKR1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1B1.

PRMT2; 13529257; ZNF253; DSP; TFE3; MCC; PAX7; HLA-B; VHL; DST; IKBKE; CSMD1; TRAF6; SMAD1

  • Q&As
  • Reviews

Q&As (15)

Ask a question
Does AKR1B1 inhibit cancer progression in humans? 02/18/2023

AKR1B1 is associated with the proliferation, invasion and metastasis of some human tumors as well as the occurrence and development of drug resistance, so it has a certain importance in tumor therapy.

What are the clinical applications of AKR1B1 inhibitors? 02/18/2023

AKR1B1 inhibitors can be used in the treatment of related diseases such as diabetes and retinopathy, as well as in drug development for diseases such as cancer and malaria.

Does the gene mutation of AKR1B1 protein cause disease? 01/10/2023

AKR1B1 gene mutation is associated with the occurrence and development of certain diseases, such as diabetes, lung cancer and so on.

What are the detection methods of AKR1B1 protein? 11/19/2022

The detection methods of AKR1B1 protein include fluorescence immunoassay, gas chromatography-mass spectrometry, transmission electron microscopy and other methods.

How does AKR1B1 play a role in central nervous system diseases? 01/27/2022

AKR1B1 is involved in glucose oxidative metabolism and neuronal survival in nervous system diseases, and can be used as a target for drug treatment of diabetic neuropathy and central nervous system diseases.

What role does AKR1B1 protein play in the immune system? 08/27/2021

AKR1B1 protein is involved in lymphocyte differentiation, cell proliferation and movement in the immune system, which can affect the immune response of the body.

What about AKR1B1 protein and where is it in the body? 07/24/2021

The AKR1B1 protein (also known as aldose reductase) is a REDOX reductase belonging to the sterol adenylate superfamily, which is capable of reducing aldehydes and alpha-beta ketones and is found in many cell types such as the eye, nervous system, kidney, bone and vascular tissue.

What diseases is AKR1B1 protein associated with? 07/13/2021

AKR1B1 protein has been implicated in a variety of diseases, such as diabetes, cancer, retinopathy, and neurological diseases.

In which organs and cells is AKR1B1 protein expressed? 12/22/2020

AKR1B1 protein is widely expressed in various organs and cells of the human body, such as retina, nervous system, kidney, blood vessels, heart and so on.

Whether AKR1B1 protein can cause retinopathy? 04/26/2020

AKR1B1 protein is commonly seen in advanced retinopathy in patients with diabetes and is associated with the development and further deterioration of this disease.

In which benign or malignant motor neuron diseases is the expression level of AKR1B1 protein up-regulated? 11/04/2019

The expression level of AKR1B1 protein is up-regulated in a variety of benign and malignant motor neuron diseases, such as ALS and amyotrophic lateral sclerosis.

What is the main role of AKR1B1 protein in human body? 08/09/2019

AKR1B1 is mainly involved in hexaosaccharide metabolism, catalyzing the conversion of glucose and aldehyde condensates to produce alcohol condensates, maintaining the balance of intracellular glucose metabolism and reducing oxidative damage to cells.

Which glycometabolic disorders are associated with the abnormal expression of AKR1B1 protein? 07/24/2019

The abnormal expression of AKR1B1 protein is associated with a variety of disorders of glucose metabolism, such as diabetes mellitus and polycystic ovary syndrome.

How does AKR1B1 function in neurodegenerative diseases 06/28/2019

AKR1B1 protein is commonly found in neurological diseases and is associated with the occurrence and development of neurodegenerative diseases.

AKR1B1 protein has many functions in the human body, what is the main role? 06/15/2019

AKR1B1 protein is closely related to the occurrence and development of diabetes, and can be used as an adjuvant drug target for diabetes, which has certain clinical application value.

Customer Reviews (4)

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Reviews
01/23/2023

    Can induce specific immune responses in immunotherapy, which has potential value for the treatment of diseases.

    09/09/2022

      Good application potential in protein engineering and recombinant expression.

      04/21/2021

        AKR1B1 can induce immune protective effect and has potential for disease prevention.

        07/18/2020

          Effective in drug delivery systems for drug loading and release.

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