AKR1B1
-
Official Full Name
aldo-keto reductase family 1, member B1 (aldose reductase)
-
Overview
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009] -
Synonyms
AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase); AR; ADR; ALR2; ALDR1; aldose reductase; aldehyde reductase 1; low Km aldose reductase; Lii5-2 CTCL tumor antigen; aldo-keto reductase family 1 member B1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
AKR1B1 involved in several pathways and played different roles in them. We selected most pathways AKR1B1 participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pentose and glucuronate interconversions | AKR1B7;ALDH2;UGT1A6B;ALDH3A2;CRYL1;KL;AKR1A1A;UGT1A4;UGT1A2 |
| Fructose and mannose metabolism | GMPPAA;PMM2;GMPPB;PFKMB;HK3;Akr1b3;PFKL;FBP1B;AKR1B10 |
| Galactose metabolism | GANC;HK3;B4GALT2;B4GALT1;GAA;G6PC3;HK1;G6PC2;GALT |
| Glycerolipid metabolism | PPAP2B;MOGAT3A;PNLIP;AGPAT1;AKR1A1B;LIPC;DGAT1A;glpK;AKR1B10 |
| Metabolic pathways | CYP2C37;LTC4S;PIGP;HSD3B5;PIGA;MBOAT1;PHYKPL;AHCY;OCRL |
AKR1B1 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1B1 itself. We selected most functions AKR1B1 had, and list some proteins which have the same functions with AKR1B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alditol:NADP+ 1-oxidoreductase activity | ADH4;AKR1C3;AKR1A1;AKR1C21;AKR1B7;AKR7A5;AKR1C2;Akr1b3;PRKRA |
| aldo-keto reductase (NADP) activity | AKR1B10;H2-KE6;AKR1C3;AKR1C6;KCNAB2;SDR42E1;CYB5A;AKR1B1;KCNAB1 |
| electron carrier activity | ETFA;CYP19A1;ACADL;GCDHB;AKR1A1;GRX2;HAAO;AOX3;CYP1A2 |
| glyceraldehyde oxidoreductase activity | Akr1b3;AKR1B1 |
AKR1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1B1.
PRMT2; 13529257; ZNF253; DSP; TFE3; MCC; PAX7; HLA-B; VHL; DST; IKBKE; CSMD1; TRAF6; SMAD1
- Reviews
- Q&As
Customer Reviews (4)
Write a reviewCan induce specific immune responses in immunotherapy, which has potential value for the treatment of diseases.
Good application potential in protein engineering and recombinant expression.
AKR1B1 can induce immune protective effect and has potential for disease prevention.
Effective in drug delivery systems for drug loading and release.
Q&As (15)
Ask a questionAKR1B1 is associated with the proliferation, invasion and metastasis of some human tumors as well as the occurrence and development of drug resistance, so it has a certain importance in tumor therapy.
AKR1B1 inhibitors can be used in the treatment of related diseases such as diabetes and retinopathy, as well as in drug development for diseases such as cancer and malaria.
AKR1B1 gene mutation is associated with the occurrence and development of certain diseases, such as diabetes, lung cancer and so on.
The detection methods of AKR1B1 protein include fluorescence immunoassay, gas chromatography-mass spectrometry, transmission electron microscopy and other methods.
AKR1B1 is involved in glucose oxidative metabolism and neuronal survival in nervous system diseases, and can be used as a target for drug treatment of diabetic neuropathy and central nervous system diseases.
AKR1B1 protein is involved in lymphocyte differentiation, cell proliferation and movement in the immune system, which can affect the immune response of the body.
The AKR1B1 protein (also known as aldose reductase) is a REDOX reductase belonging to the sterol adenylate superfamily, which is capable of reducing aldehydes and alpha-beta ketones and is found in many cell types such as the eye, nervous system, kidney, bone and vascular tissue.
AKR1B1 protein has been implicated in a variety of diseases, such as diabetes, cancer, retinopathy, and neurological diseases.
AKR1B1 protein is widely expressed in various organs and cells of the human body, such as retina, nervous system, kidney, blood vessels, heart and so on.
AKR1B1 protein is commonly seen in advanced retinopathy in patients with diabetes and is associated with the development and further deterioration of this disease.
The expression level of AKR1B1 protein is up-regulated in a variety of benign and malignant motor neuron diseases, such as ALS and amyotrophic lateral sclerosis.
AKR1B1 is mainly involved in hexaosaccharide metabolism, catalyzing the conversion of glucose and aldehyde condensates to produce alcohol condensates, maintaining the balance of intracellular glucose metabolism and reducing oxidative damage to cells.
The abnormal expression of AKR1B1 protein is associated with a variety of disorders of glucose metabolism, such as diabetes mellitus and polycystic ovary syndrome.
AKR1B1 protein is commonly found in neurological diseases and is associated with the occurrence and development of neurodegenerative diseases.
AKR1B1 protein is closely related to the occurrence and development of diabetes, and can be used as an adjuvant drug target for diabetes, which has certain clinical application value.
Ask a Question for All AKR1B1 Products
Required fields are marked with *
My Review for All AKR1B1 Products
Required fields are marked with *
