AKR1B1 Protein


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Official Full Name aldo-keto reductase family 1, member B1 (aldose reductase)
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
Synonyms AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase); AR; ADR; ALR2; ALDR1; aldose reductase; aldehyde reductase 1; low Km aldose reductase; Lii5-2 CTCL tumor antigen; aldo-keto reductase family 1 member B1;
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKR1B1-1219H Recombinant Human AKR1B1 protein, GST-tagged E.coli GST
    Human AKR1B1-136H Recombinant Human AKR1B1 protein E.coli N/A
    Human AKR1B1-2496H Recombinant Human AKR1B1, His tagged E.coli His
    Human AKR1B1-3168H Recombinant Human AKR1B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human AKR1B1-409H Recombinant Human AKR1B1 Protein, GST-tagged Wheat Germ GST
    Human AKR1B1-47HCL Recombinant Human AKR1B1 cell lysate N/A
    Human AKR1B1-9156H Recombinant Human AKR1B1, His-tagged E.coli His
    Rat Akr1b1-3269R Recombinant Rat Akr1b1, His-tagged E.Coli or Yeast His
    Rat AKR1B1-596R Recombinant Rat AKR1B1 Protein Mammalian Cell His
    Rhesus Macaque AKR1B1-292R Recombinant Rhesus monkey AKR1B1 Protein, His-tagged Mammalian Cell His
    Zebrafish AKR1B1-283Z Recombinant Zebrafish AKR1B1 Mammalian Cell His

    AKR1B1 involved in several pathways and played different roles in them. We selected most pathways AKR1B1 participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions AKR1B10; UGP2; UGP2A; AKR1B1; Akr1b3; UGT1A6; UGT2B7; DHDH; UGDH; UGT1AB
    Fructose and mannose metabolism HK2; AKR1B1; FUK; TPI1B; GMDS; DHRS13L1; TIGARA; ALDOCA; FPGT; TPI1A
    Galactose metabolism HKDC1; HK1; aLA; LCT; GAA; AKR1B1L; PFKM; G6PCA.2; SI; GALM
    Glycerolipid metabolism DGAT1; PNPLA3; GK2; AGPAT2; PPAP2C; GLYCTK; DAK; TAE1; MGLL; DGAT2
    Metabolic pathways GGT5; TSTA3; DAD1; ACADL; AK7; ST3GAL3; P4HA2; NOS1; NDUFV3; CYP2A12

    AKR1B1 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1B1 itself. We selected most functions AKR1B1 had, and list some proteins which have the same functions with AKR1B1. You can find most of the proteins on our site.

    Function Related Protein
    alditol:NADP+ 1-oxidoreductase activity AKR7A5; AKR1B8; Akr1b3; AKR1C2; ADH4; AKR1B7; AKR7A2; AKR1B1; AKR1A1; AKR1C21
    aldo-keto reductase (NADP) activity KCNAB1; AKR7A3; AKR1C4; KCNAB2; HSD11B1LA; AKR1C21; AKR1C3; HSD3B6; AKR1C6; AKR1B1
    electron carrier activity SDHC; GRX2; ACOX2; IVD; CYP19A1; COX7A3; ACADSB; ETFDH; PTGESL; ACAD11
    glyceraldehyde oxidoreductase activity Akr1b3; AKR1B1

    AKR1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1B1.

    PRMT2; 13529257; ZNF253; DSP; TFE3; MCC; PAX7; HLA-B; VHL; DST; IKBKE; CSMD1; TRAF6; SMAD1

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