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Official Full Name aldehyde dehydrogenase 5 family, member A1
Background This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms ALDH5A1; aldehyde dehydrogenase 5 family, member A1; succinate-semialdehyde dehydrogenase, mitochondrial; SSADH; SSDH; succinate semialdehyde dehydrogenase; aldehyde dehydrogenase family 5 member A1; mitochondrial succinate semialdehyde dehydrogenase; NAD
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALDH5A1-1324H Recombinant Human ALDH5A1 Protein (48-535 aa), His-tagged Yeast His
    Human ALDH5A1-26496TH Recombinant Human ALDH5A1, His-tagged E.coli His
    Human ALDH5A1-27041TH Recombinant Human ALDH5A1, His-tagged E.coli His
    Human ALDH5A1-2821H Recombinant Human ALDH5A1, His-tagged E.coli His
    Human ALDH5A1-450H Recombinant Human ALDH5A1 Protein, GST-tagged Wheat Germ GST
    Human ALDH5A1-60HCL Recombinant Human ALDH5A1 cell lysate N/A
    Human ALDH5A1-9562H Recombinant Human ALDH5A1, His-tagged E.coli His
    Zebrafish ALDH5A1-6188Z Recombinant Zebrafish ALDH5A1 Mammalian Cell His

    aldh5a1 involved in several pathways and played different roles in them. We selected most pathways aldh5a1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with aldh5a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alanine, aspartate and glutamate metabolism GPT; AGXTB; GLULC; GLUD2; GOT1; GLULA; GPT2; GOT2A; GFPT1; CPS1
    Butanoate metabolism HMGCS1; HADH; BDH2; GAD2; Acsm2a; ACAT1; DHRS13L1; OXCT2B; AACS; HMGCS2
    Metabolic pathways MGAT1; FLAD1; PIP5K1C; B3GNT5B; NDUFS1; GAD2; NDUFV1; SDHB; ATP6V0A1A; NDUFB4

    aldh5a1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity, protein homodimerization activity, succinate-semialdehyde dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by aldh5a1 itself. We selected most functions aldh5a1 had, and list some proteins which have the same functions with aldh5a1. You can find most of the proteins on our site.

    Function Related Protein
    aldehyde dehydrogenase (NAD) activity ALDH1B1; Aldh1a7; ALDH4A1; ALDH3A2A; ALDH3A2; ALDH8A1; ALDH9A1B; ALDH6A1; ALDH3A2B; ALDH1A3
    protein homodimerization activity BHLHA15; ECT2; CADM1B; ADH1; NR4A2; APOA1BP; UGT1A3; CHKA; PVRL1; SP1
    succinate-semialdehyde dehydrogenase (NAD+) activity ALDH5A1
    succinate-semialdehyde dehydrogenase [NAD(P)+] activity ALDH5A1

    aldh5a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with aldh5a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of aldh5a1.


    Zuo, QS; Li, D; et al. Study on the Regulatory Mechanism of the Lipid Metabolism Pathways during Chicken Male Germ Cell Differentiation Based on RNA-Seq. PLOS ONE 10:-(2015).
    Wang, L; Guo, HJ; et al. Enrichment and characterization of cancer stem-like cells from a cervical cancer cell line. MOLECULAR MEDICINE REPORTS 9:2117-2123(2014).

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