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Recombinant Human ALDH5A1 Protein (48-535 aa), His-tagged

Cat.No. : ALDH5A1-1324H
Product Overview : Recombinant Human ALDH5A1 Protein (48-535 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Metabolism. Protein Description: Full Length of Mature Protein.
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Description : Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Source : Yeast
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 54.3 kDa
Protein length : 48-535 aa
AA Sequence : AGRLAGLSAALLRTDSFVGGRWLPA AATFPVQDPASGAALGMVADCGVRE ARAAVRAAYEAFCRWREVSAKERSS LLRKWYNLMIQNKDDLARIITAESG KPLKEAHGEILYSAFFLEWFSEEAR RVYGDIIHTPAKDRRALVLKQPIGV AAVITPWNFPSAMITRKVGAALAAG CTVVVKPAEDTPFSALALAELASQA GIPSGVYNVIPCSRKNAKEVGEAIC TDPLVSKISFTGSTTTGKILLHHAA NSVKRVSMELGGLAPFIVFDSANVD QAVAGAMASKFRNTGQTCVCSNQFL VQRGIHDAFVKAFAEAMKKNLRVGN GFEEGTTQGPLINEKAVEKVEKQVN DAVSKGATVVTGGKRHQLGKNFFEP TLLCNVTQDMLCTHEETFGPLAPVI KFDTEEEAIAIANAADVGLAGYFYS QDPAQIWRVAEQLEVGMVGVNEGLI SSVECPFGGVKQSGLGREGSKYGID EYLELKYVCYGGL
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Gene Name : ALDH5A1 aldehyde dehydrogenase 5 family, member A1 [ Homo sapiens ]
Official Symbol : ALDH5A1
Synonyms : ALDH5A1; SSADH; SSDH;
Gene ID : 7915
mRNA Refseq : NM_001080
Protein Refseq : NP_001071
MIM : 610045
UniProt ID : P51649

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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Is ALDH5A1 involved in any other metabolic pathways? 03/21/2023

Along with its primary role in GABA metabolism, ALDH5A1 may participate in other metabolic pathways. It has been suggested to be involved in the detoxification of certain aldehydes, although the extent of its contribution to these pathways is not fully understood. Further research is needed to elucidate the involvement of ALDH5A1 in other metabolic processes.

What happens when ALDH5A1 is deficient or mutated? 09/15/2022

Deficiency or mutations in ALDH5A1 result in succinic semialdehyde dehydrogenase deficiency (SSADH), also known as GABA-transaminase deficiency. This condition leads to the accumulation of elevated levels of SSA and GABA-related metabolites, impacting GABAergic neurotransmission. SSADH is characterized by various neurological symptoms, including developmental delays, intellectual disability, seizures, ataxia, hypotonia, and behavioral abnormalities.

Are there any known interactions or pathways involving ALDH5A1? 03/05/2022

ALDH5A1 is involved in the GABA metabolic pathway, as it plays a crucial role in converting succinic semialdehyde to succinate. It is also implicated in oxidative stress defense mechanisms and has been linked to neurodevelopmental processes, such as neuronal migration and axon guidance.

What are the functions of ALDH5A1 in the body? 11/05/2021

ALDH5A1 plays a crucial role in the metabolism of gamma-aminobutyric acid (GABA), a neurotransmitter in the central nervous system. It catalyzes the conversion of succinic semialdehyde (SSA) to succinate, preventing the accumulation of SSA and GABA-related metabolites. Thus, ALDH5A1 acts as an important enzyme in the GABA degradation pathway, maintaining proper GABA levels and neuronal function.

Are there any ongoing studies or therapies targeting ALDH5A1? 10/04/2021

Yes, there is ongoing research into the development of small molecules and inhibitors that can modulate ALDH5A1 activity for therapeutic purposes. Targeting ALDH5A1 may offer potential treatments for neurological disorders, cancer, and other conditions related to ALDH5A1 dysregulation.

Are there any known genetic variations or mutations in ALDH5A1? 08/07/2021

Yes, mutations in the ALDH5A1 gene are associated with succinic semialdehyde dehydrogenase deficiency (SSADH). These mutations can lead to reduced enzyme activity or protein instability, resulting in the accumulation of toxic levels of succinic semialdehyde and GABA-related metabolites.

How is ALDH5A1 relevant to personalized medicine? 06/07/2021

ALDH5A1 activity and expression levels could serve as biomarkers to predict drug response and optimize treatment strategies. Determining an individual's ALDH5A1 status may help personalize medication regimens for better therapeutic outcomes.

Is ALDH5A1 associated with any diseases or disorders? 04/26/2021

Yes, mutations or dysregulation in the ALDH5A1 gene can lead to a disorder called succinic semialdehyde dehydrogenase deficiency (SSADH). This condition disrupts GABA metabolism and is associated with various neurological symptoms, such as developmental delay, intellectual disability, and seizures.

Is ALDH5A1 expressed in other tissues besides the brain? 01/07/2021

Yes, while ALDH5A1 is primarily expressed in the brain, it is also found in other tissues, albeit at lower levels. ALDH5A1 expression has been reported in the liver, kidney, heart, and other organs, indicating its involvement in other metabolic processes outside the central nervous system.

How is ALDH5A1 regulated? 03/13/2019

The expression and activity of ALDH5A1 can be regulated at various levels. Transcriptional regulation through specific transcription factors can control the gene expression of ALDH5A1. Additionally, post-translational modifications, such as phosphorylation or acetylation, can modulate the protein's activity. Various signaling pathways and genetic factors can influence ALDH5A1 regulation.

How is ALDH5A1 deficiency diagnosed? 11/29/2018

ALDH5A1 deficiency is typically diagnosed through biochemical tests, such as measuring elevated levels of GABA and SSA in body fluids, including urine and cerebrospinal fluid. Genetic testing is also performed to confirm the presence of mutations in the ALDH5A1 gene. Additionally, clinical evaluation and neurological assessment may be conducted to evaluate the symptoms and presentation of the individual.

Are there any known natural inhibitors or activators of ALDH5A1? 06/22/2016

While natural inhibitors or activators specific to ALDH5A1 have not been extensively studied, certain compounds that modulate the activity or expression of aldehyde dehydrogenase enzymes in general may indirectly affect ALDH5A1 as well. For instance, some chemicals or drugs can inhibit or activate aldehyde dehydrogenases, which potentially includes ALDH5A1, depending on their specificity.

Can ALDH5A1 be used as a potential therapeutic target? 03/21/2016

Targeting ALDH5A1 holds promise for therapeutic intervention, especially in the context of succinic semialdehyde dehydrogenase deficiency (SSADH). Developing drugs or treatments that can modulate ALDH5A1 activity or stabilize the mutated protein could potentially ameliorate the symptoms associated with this disorder. However, further research is needed to fully understand the implications and feasibility of targeting ALDH5A1 for therapeutic purposes.

Customer Reviews (4)

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Reviews
10/09/2022

    Their expertise and assistance have been invaluable in troubleshooting and providing insightful solutions, greatly enhancing the progress of my experiments.

    10/14/2020

      The ALDH5A1 Protein's superior stability and functional performance render it an indispensable tool for a wide range of scientific investigations.

      08/03/2018

        They have proven to be a timely and reliable resource, readily addressing any concerns or challenges that arise during my research.

        04/11/2016

          What further sets the ALDH5A1 Protein apart is the outstanding technical support provided by the manufacturer.

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