ALDOB
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Official Full Name
aldolase B, fructose-bisphosphate
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Overview
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related housekeeping genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. -
Synonyms
ALDOB; aldolase B, fructose-bisphosphate; fructose-bisphosphate aldolase B; ALDB; ALDO B; ALDOB_HUMAN; Aldolase 2; Aldolase B; Aldolase B fructose bisphosphate; Aldolase2; AldolaseB; EC 4.1.2.13; Fructose bisphosphate aldolase B; Liver type aldolase; Liver-type aldolase; OTTHUMP00000021803; OTTHUMP00000021804; aldolase B, fructose-bisphosphatase; ALDO2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Chicken
- Human
- Mouse
- Rabbit
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His|SUMO
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ALDOB involved in several pathways and played different roles in them. We selected most pathways ALDOB participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycolysis / Gluconeogenesis | PKLR;AKR1A1A;ADH6;PGAM1B;HK1;LDHAL6A;ACSS1;ENO3;PGAM2 |
Pentose phosphate pathway | H6PD;PRPS2;GPIB;TKTB;PGM2;TKTL2;GPIA;PRPS1B;GPI |
Fructose and mannose metabolism | ALDOC;FBP1B;PMM2;PFKFB3;PFKM;ENOSF1;PFKFB4;PFKL;HK3 |
Metabolic pathways | GALNTL6;GAD2;OXSM;LIAS;CTH;PLA2G2F;PC;ctaG;NT5C1A |
Carbon metabolism | FBP1;G6PDX;PKMA;PGAM1B;ackA;PRPS1A;IDH3A;ACO1;PFKMA |
Biosynthesis of amino acids | PKMB;PYCRL;PYCR1B;PSPH;ACO2;PC;GPT;ENO2;PHGDH |
ALDOB has several biochemical functions, for example, ATPase binding, cytoskeletal protein binding, fructose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDOB itself. We selected most functions ALDOB had, and list some proteins which have the same functions with ALDOB. You can find most of the proteins on our site.
Function | Related Protein |
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ATPase binding | ATP1B2;NOP58;ATP1B3;ATP6V0A1A;CHRNA7;EZR;LCK;NKAIN1;USP25 |
cytoskeletal protein binding | ACTN2;SLC8A1;CAPN2;EZRB;EPB41L4A;NF2B;CAPN10;PTPN3;EZRA |
fructose binding | PFKM;ALDOB;PFKL;ALDOA |
fructose-1-phosphate aldolase activity | |
fructose-bisphosphate aldolase activity | ALDOCA;ALDOB;ALDOA;ALDOAB;ALDOCB;ALDOAA;ALDOC |
identical protein binding | KLHL7;SLC2A1;CCL4;IK;MCM6;CRYAB;ADORA2A;SEPT7;CALCA |
phosphatidylcholine binding | APOA4A;RASGRP1;SERPINA5;APOA1;APOA4B.1;ESYT2;APOA2;APOA5;CHMP2A |
protein binding | PPFIA4;CD79A;DHH;FGFBP1;CSRNP2;NHLRC1;NADK;SH3YL1;GNB2L1 |
ALDOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDOB here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDOB.
BBS7; BBS1; BBS4; BBS2; Slc12a1; HUS1; BUB1
- Q&As
- Reviews
Q&As (6)
Ask a questionHereditary fructose intolerance is caused by a genetic mutation in the ALDOB gene, which leads to a deficiency or complete absence of the ALDOB protein. Without functioning ALDOB protein, the body is unable to properly metabolize fructose, leading to a build-up of toxic byproducts and causing the symptoms of HFI.
Yes, there are multiple mutations identified in the ALDOB gene that can cause hereditary fructose intolerance. These mutations can vary in their severity and impact on the function of the ALDOB protein.
Yes, mutations in the ALDOB gene can have other health implications. In some cases, mutations that cause a partial deficiency of the ALDOB protein may lead to a milder form of fructose intolerance or cause symptoms only when excessive amounts of fructose are consumed. Additionally, there is some evidence to suggest that ALDOB gene mutations may be associated with an increased risk of developing certain types of liver diseases. However, further research is needed to fully understand the potential implications.
Yes, prenatal testing is available for hereditary fructose intolerance. It involves analyzing fetal DNA obtained through procedures like chorionic villus sampling (CVS) or amniocentesis to identify mutations in the ALDOB gene. This allows for early detection of the condition, aiding in family planning and preparation for managing the condition after birth.
The ALDOB protein is primarily involved in fructose metabolism, but it also has other functions. It plays a role in gluconeogenesis, a process in which the liver produces glucose from non-carbohydrate sources. It is also involved in maintaining the balance of sugar molecules in the body and supporting normal liver function.
Hereditary fructose intolerance is typically diagnosed through a combination of clinical symptoms, biochemical testing, and genetic testing. Symptoms of the condition may include abdominal pain, nausea, vomiting, and low blood sugar levels. Biochemical testing involves measuring the levels of certain metabolites, such as fructose and its byproducts, in the blood or urine. Genetic testing can confirm the presence of specific mutations in the ALDOB gene.
Customer Reviews (3)
Write a reviewIt has been extensively used in protein-protein interaction studies, enzymatic assays, and structural analyses, showcasing its reliability and adaptability in diverse research areas.
With the ALDOB Protein, I have the confidence to generate critical insights and drive significant advancements in my field.
I am certain of obtaining reliable and reproducible results, enabling me to contribute to scientific progress and make new discoveries.
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