ALDOB
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Official Full Name
aldolase B, fructose-bisphosphate -
Overview
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related housekeeping genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. -
Synonyms
ALDOB;aldolase B, fructose-bisphosphate;fructose-bisphosphate aldolase B;ALDB;ALDO B;ALDOB_HUMAN;Aldolase 2;Aldolase B;Aldolase B fructose bisphosphate;Aldolase2;AldolaseB;EC 4.1.2.13;Fructose bisphosphate aldolase B;Liver type aldolase;Liver-type aldolase;OTTHUMP00000021803;OTTHUMP00000021804;aldolase B, fructose-bisphosphatase;ALDO2
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rabbit
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- GST
- Non
- DDK
- Myc
- SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ALDOB-1918H | Recombinant Human ALDOB Protein, His tagged | E.coli | Human | His | ||
| ALDOB-9567H | Recombinant Human ALDOB, His-tagged | E.coli | Human | His | 1-316a.a. | |
| ALDOB-1817C | Recombinant Chicken ALDOB | Mammalian Cells | Chicken | His |
|
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| ALDOB-456H | Recombinant Human ALDOB Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| ALDOB-505H | Recombinant Human ALDOB protein, GST-tagged | E.coli | Human | GST | 2-364 a.a. |
|
| ALDOB-9718Z | Recombinant Zebrafish ALDOB | Mammalian Cells | Zebrafish | His |
|
|
| ALDOB-8911HCL | Recombinant Human ALDOB 293 Cell Lysate | HEK293 | Human | Non |
|
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| ALDOB-0641H | Recombinant Human ALDOB Protein (Thr9-Tyr364), N-His-tagged | E.coli | Human | His | Thr9-Tyr364 |
|
| ALDOB-1325R | Recombinant Rabbit ALDOB Protein (2-364 aa), His-tagged | Yeast | Rabbit | His | 2-364 aa |
|
| ALDOB-1534HF | Recombinant Full Length Human ALDOB Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 316 amino acids |
|
| Aldob-1596M | Recombinant Mouse Aldob Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
|
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| ALDOB-26495TH | Recombinant Human ALDOB | Wheat Germ | Human | Non | 83 amino acids |
|
| ALDOB-326R | Recombinant Rabbit ALDOB Protein (2-364 aa), His-SUMO-tagged | E.coli | Rabbit | His&SUMO | 2-364 aa |
|
| ALDOB-5893H | Recombinant Human ALDOB Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
|
Involved Pathway
ALDOB involved in several pathways and played different roles in them. We selected most pathways ALDOB participated on our site, such as Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | BPGM,ALDOAA,LDHAL6A,ALDOCA,PFKP,GAPDHS,HKDC1,ALDOC,ALDH2.2,PGAM1 |
| Pentose phosphate pathway | FBP2,GPIA,GPI,ALDOCA,PGLS,G6PDX,ALDOAA,PFKMA,PFKM,PRPS1A |
| Metabolic pathways | FBP1A,CYP2R1,BPGM,POLR3B,DHFRL1,NDUFC1,CDIPT,AOX2P,UCK2B,ALG2 |
| Fructose and mannose metabolism | PFKFB2A,ALDOCA,PFKL,PFKFB4,TPI1A,TIGARA,TPI1B,Akr1b3,TSTA3,KHK |
| Carbon metabolism | SDHB,GOT1,TKTB,PDHA1B,ESD,ACAT2,pykF,ALDOCA,FBP1B,G6PDX |
| Biosynthesis of amino acids | PGAM1,ALDOA,RPE,SHMT2,GPT,PFKMA,SDS,PC,MAT2A,GAPDH |
Protein Function
ALDOB has several biochemical functions, for example, ATPase binding,cytoskeletal protein binding,fructose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDOB itself. We selected most functions ALDOB had, and list some proteins which have the same functions with ALDOB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytoskeletal protein binding | FLNC,MYLIP,RPH3AL,PACSIN1,PACSIN1A,FRMD5,TPM1,LDB3,LIN7C,EZRB |
| ATPase binding | SVIP,ATP6V1G1,FXYD1,SLC26A9,Ar,SNTA1,DNAJB1,FXYD7,DRD1,UBXN1 |
| fructose binding | PFKL,ALDOA,PFKM |
| identical protein binding | G6PDX,HSP90AA1,CEACAM5,DPP4,GRB7,TGFB3,PTEN,SMAD6,ADIPOQ,FUS |
| protein binding | TNNI3K,LNX2,TTR,RGS17,CDC6,JAK3,MKI67,ARHGAP17,ADRBK1,SCIMP |
| phosphatidylcholine binding | RPE65,APOA2,APOA1,APOA4,RASGRP1,APOA4A,APOA1A,SERPINA5,PCTP,APOA4B.2 |
| fructose-bisphosphate aldolase activity | ALDOCA,ALDOCB,ALDOAA,ALDOAB,ALDOA,ALDOC |
Interacting Protein
ALDOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDOB here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDOB.
BBS7;BBS1;BBS4;BBS2;Slc12a1;HUS1;BUB1
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