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ALDOB

  • Official Full Name

    aldolase B, fructose-bisphosphate

  • Overview

    Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related housekeeping genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
  • Synonyms

    ALDOB; aldolase B, fructose-bisphosphate; fructose-bisphosphate aldolase B; ALDB; ALDO B; ALDOB_HUMAN; Aldolase 2; Aldolase B; Aldolase B fructose bisphosphate; Aldolase2; AldolaseB; EC 4.1.2.13; Fructose bisphosphate aldolase B; Liver type aldolase; Liver-type aldolase; OTTHUMP00000021803; OTTHUMP00000021804; aldolase B, fructose-bisphosphatase; ALDO2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His|SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALDOB-505H Recombinant Human ALDOB protein, GST-tagged E.coli GST Ala2-Tyr364
Human ALDOB-1918H Recombinant Human Aldolase B, Fructose-Bisphosphate, His-tagged His
Human ALDOB-456H Recombinant Human ALDOB Protein, GST-tagged Wheat Germ GST
Human ALDOB-9567H Recombinant Human ALDOB, His-tagged E.coli His 1-316a.a.
Human ALDOB-8911HCL Recombinant Human ALDOB 293 Cell Lysate HEK293 N/A
Human ALDOB-1534HF Recombinant Full Length Human ALDOB Protein, GST-tagged In Vitro Cell Free System GST 316 amino acids
Human ALDOB-26495TH Recombinant Human ALDOB Wheat Germ N/A 83 amino acids
Human ALDOB-5893H Recombinant Human ALDOB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALDOB-0641H Recombinant Human ALDOB Protein (Thr9-Tyr364), N-His-tagged E.coli N-His Thr9-Tyr364
Mouse Aldob-1596M Recombinant Mouse Aldob Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rabbit ALDOB-1325R Recombinant Rabbit ALDOB Protein (2-364 aa), His-tagged Yeast His 2-364 aa
Rabbit ALDOB-326R Recombinant Rabbit ALDOB Protein (2-364 aa), His-SUMO-tagged E.coli His/SUMO 2-364 aa
Zebrafish ALDOB-9718Z Recombinant Zebrafish ALDOB Mammalian Cell His
Chicken ALDOB-1817C Recombinant Chicken ALDOB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ALDOB involved in several pathways and played different roles in them. We selected most pathways ALDOB participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisPKLR;AKR1A1A;ADH6;PGAM1B;HK1;LDHAL6A;ACSS1;ENO3;PGAM2
Pentose phosphate pathwayH6PD;PRPS2;GPIB;TKTB;PGM2;TKTL2;GPIA;PRPS1B;GPI
Fructose and mannose metabolismALDOC;FBP1B;PMM2;PFKFB3;PFKM;ENOSF1;PFKFB4;PFKL;HK3
Metabolic pathwaysGALNTL6;GAD2;OXSM;LIAS;CTH;PLA2G2F;PC;ctaG;NT5C1A
Carbon metabolismFBP1;G6PDX;PKMA;PGAM1B;ackA;PRPS1A;IDH3A;ACO1;PFKMA
Biosynthesis of amino acidsPKMB;PYCRL;PYCR1B;PSPH;ACO2;PC;GPT;ENO2;PHGDH

ALDOB has several biochemical functions, for example, ATPase binding, cytoskeletal protein binding, fructose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDOB itself. We selected most functions ALDOB had, and list some proteins which have the same functions with ALDOB. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingATP1B2;NOP58;ATP1B3;ATP6V0A1A;CHRNA7;EZR;LCK;NKAIN1;USP25
cytoskeletal protein bindingACTN2;SLC8A1;CAPN2;EZRB;EPB41L4A;NF2B;CAPN10;PTPN3;EZRA
fructose bindingPFKM;ALDOB;PFKL;ALDOA
fructose-1-phosphate aldolase activity
fructose-bisphosphate aldolase activityALDOCA;ALDOB;ALDOA;ALDOAB;ALDOCB;ALDOAA;ALDOC
identical protein bindingKLHL7;SLC2A1;CCL4;IK;MCM6;CRYAB;ADORA2A;SEPT7;CALCA
phosphatidylcholine bindingAPOA4A;RASGRP1;SERPINA5;APOA1;APOA4B.1;ESYT2;APOA2;APOA5;CHMP2A
protein bindingPPFIA4;CD79A;DHH;FGFBP1;CSRNP2;NHLRC1;NADK;SH3YL1;GNB2L1

ALDOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDOB here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDOB.

BBS7; BBS1; BBS4; BBS2; Slc12a1; HUS1; BUB1

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How is the ALDOB protein related to hereditary fructose intolerance (HFI)? 10/27/2022

Hereditary fructose intolerance is caused by a genetic mutation in the ALDOB gene, which leads to a deficiency or complete absence of the ALDOB protein. Without functioning ALDOB protein, the body is unable to properly metabolize fructose, leading to a build-up of toxic byproducts and causing the symptoms of HFI.

Are there different types of mutations in the ALDOB gene associated with hereditary fructose intolerance? 09/02/2020

Yes, there are multiple mutations identified in the ALDOB gene that can cause hereditary fructose intolerance. These mutations can vary in their severity and impact on the function of the ALDOB protein.

Can mutations in the ALDOB gene have other health implications besides hereditary fructose intolerance? 12/28/2019

Yes, mutations in the ALDOB gene can have other health implications. In some cases, mutations that cause a partial deficiency of the ALDOB protein may lead to a milder form of fructose intolerance or cause symptoms only when excessive amounts of fructose are consumed. Additionally, there is some evidence to suggest that ALDOB gene mutations may be associated with an increased risk of developing certain types of liver diseases. However, further research is needed to fully understand the potential implications.

Can hereditary fructose intolerance be detected before birth? 10/13/2019

Yes, prenatal testing is available for hereditary fructose intolerance. It involves analyzing fetal DNA obtained through procedures like chorionic villus sampling (CVS) or amniocentesis to identify mutations in the ALDOB gene. This allows for early detection of the condition, aiding in family planning and preparation for managing the condition after birth.

Are there any other functions or roles of the ALDOB protein besides fructose metabolism? 06/28/2019

The ALDOB protein is primarily involved in fructose metabolism, but it also has other functions. It plays a role in gluconeogenesis, a process in which the liver produces glucose from non-carbohydrate sources. It is also involved in maintaining the balance of sugar molecules in the body and supporting normal liver function.

How is hereditary fructose intolerance diagnosed? 09/19/2016

Hereditary fructose intolerance is typically diagnosed through a combination of clinical symptoms, biochemical testing, and genetic testing. Symptoms of the condition may include abdominal pain, nausea, vomiting, and low blood sugar levels. Biochemical testing involves measuring the levels of certain metabolites, such as fructose and its byproducts, in the blood or urine. Genetic testing can confirm the presence of specific mutations in the ALDOB gene.

Customer Reviews (3)

Write a review
Reviews
03/02/2021

    It has been extensively used in protein-protein interaction studies, enzymatic assays, and structural analyses, showcasing its reliability and adaptability in diverse research areas.

    01/18/2021

      With the ALDOB Protein, I have the confidence to generate critical insights and drive significant advancements in my field.

      02/16/2020

        I am certain of obtaining reliable and reproducible results, enabling me to contribute to scientific progress and make new discoveries.

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