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ALG14

  • Official Full Name

    ALG14 asparagine-linked glycosylation 14 homolog (S. cerevisiae) [ Homo sapiens ]

  • Overview

    Asparagine (N)-glycosylation is an essential modification that regulates protein folding and stability. ALG13 and ALG14 (MIM 612866) constitute the UDP-GlcNAc transferase, which catalyzes a key step in endoplasmic reticulum N-linked glycosylation (Averbeck et al., 2007 [PubMed 17686769]).
  • Synonyms

    asparagine-linked glycosylation 14 homolog (S. cerevisiae); MGC19780; asparagine-linked glycosylation 14 homolog (yeast); UDP-N-acetylglucosamine transferase subunit ALG14 homolog; ALG14;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALG14-9574H Recombinant Human ALG14, His-tagged E.coli His 27-216a.a.
Human ALG14-8907HCL Recombinant Human ALG14 293 Cell Lysate HEK293 N/A
Mouse ALG14-1545M Recombinant Mouse ALG14 Protein Mammalian Cell His
Mouse ALG14-465M Recombinant Mouse ALG14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALG14-465M-B Recombinant Mouse ALG14 Protein Pre-coupled Magnetic Beads HEK293
Rat ALG14-629R Recombinant Rat ALG14 Protein Mammalian Cell His
Rat ALG14-285R Recombinant Rat ALG14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ALG14-285R-B Recombinant Rat ALG14 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ALG14-1598Z Recombinant Zebrafish ALG14 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ALG14 Related Articles

ALG14 involved in several pathways and played different roles in them. We selected most pathways ALG14 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asparagine N-linked glycosylationST6GAL2B;TRAPPC3;GORASP1;ALG14;SCFD1;DDOST;TMED2;SEC16B;NAPAA
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinST3GAL3A;NEU3;MPDU1;MPDU1B;GNE;ZNF408;ST6GALNAC1.2;ALG14;ALG2
Metabolic pathwaysCYP4F18;ATP6V0A4;UGT1A7;ATP6V0D2;PIK3C3;PNLIP;HSD17B12;CMPK1;MAT1A
Metabolism of proteinsGALNT6;EEF1G;EXOC6;KDELR3;MUC21;GRP;ADAMTS20;TMED10;EEF1A1
N-Glycan biosynthesisDOLPP1;RABGNT1;ALG6;GANAB;ALG11;MGAT2;ALG1;MGAT5B;STT3B
Post-translational protein modificationADAMTS8;TRAPPC5;MUC5AC;ADAMTS15;DNAJC24;MPDU1;DHPS;DPH5;SUMF2

ALG14 has several biochemical functions, for example, contributes_to N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity, protein anchor. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG14 itself. We selected most functions ALG14 had, and list some proteins which have the same functions with ALG14. You can find most of the proteins on our site.

Function Related Protein
contributes_to N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
protein anchorRAPSN;NUP153;CIB1;SUN3;AKAP6;SUN1;MYH9;ALG14;SUN5

ALG14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG14 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG14.

Monies, DM; Al-Hindi, HN; et al. Clinical and pathological heterogeneity of a congenital disorder of glycosylation manifesting as a myasthenic/myopathic syndrome. NEUROMUSCULAR DISORDERS 24:353-359(2014).
Wu, JHY; Lemaitre, RN; et al. Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway Results From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. CIRCULATION-CARDIOVASCULAR GENETICS 6:171-+(2013).
  • Q&As
  • Reviews

Q&As (18)

Ask a question
What effect does overexpression or knockout of ALG14 have on cells? 12/27/2022

Overexpression or knockout of ALG14 may negatively affect cellular glycosylation and the stability of ER and Golgi bodies, but the specific effects need to be further explored.

In what neurological diseases does ALG14 play a role? 09/04/2022

The relationship between ALG14 and neurological diseases needs further study, but it is known to be associated with diseases such as intellectual deficiency and idiopathic epilepsy.

How neurological diseases can ALG14 mutations cause? 04/29/2022

ALG14 mutations have been shown to be associated with a variety of neurological disorders such as intellectual impairment and idiopathic epilepsy.

In which metabolic pathways does ALG14 play a role? 12/13/2021

ALG14 is involved in metabolic pathways such as glycosylation and glucose metabolism, and has important biological functions.

What is the position of ALG14 in cellular processes? 10/27/2021

ALG14 is mainly distributed in the endoplasmic reticulum (ER) and the Golgi apparatus.

How biological processes does ALG14 participate in? 08/22/2021

ALG14 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.

How does ALG14 regulate glycosylation? 07/27/2021

ALG14, as a member of UDP-glucose-glycosyltransferase, is involved in the synthesis and modification of sugar chains during glycosylation, and plays an important role in the glycosylation and modification of post-translational mitochondrial proteins and plasma membrane proteins.

What is the sugar chain selectivity of ALG14? 07/19/2021

This protein can selectively catalyze the specific chemical structure of sugar chains, thereby affecting the biological properties and function of proteins.

What are the molecular biological characteristics of ALG14? 03/24/2021

This is an important UDP-glucose-glycosyltransferase. It plays a very important role in protein glycosylation and cell growth.

To which family members is ALG14 functionally similar? 03/21/2021

As a member of the UDP-glucose-glycosyltransferase family, ALG14 is functionally similar to ALG13, ALG1 and other family members.

Which non-cellular autophagy pathways are involved in ALG14? 01/31/2021

Although the function of ALG14 in the non-cellular autophagy pathway has not been clearly studied, there are indications that it may be involved in the TCA cycle and gluconeogenic pathway.

What effect does ALG14 have on the structure, length and branching of sugar chains? 12/26/2020

This protein can influence the specific structure, length and branching of sugar chains through selective glycosylation reactions.

What is the interacting protein of ALG14? 12/04/2020

ALG14 interacts with glycosylation enzymes such as ALG13, ALG1 and mannosyltransferase to jointly regulate the glycosylation process of proteins.

Does ALG14 participate in mitochondrial glucose metabolism? 09/29/2020

ALG14 may be involved in mitochondrial glucose metabolism, although more research is needed to investigate the specific mechanism.

What is the relationship between ALG14 and the occurrence and development of diabetes? 07/15/2020

There is currently no direct evidence that ALG14 is associated with the onset and development of diabetes, but glycosylation plays a key role in metabolism and disease development, so it may be involved in diabetes.

Is ALG14 involved in the occurrence of neurodegenerative diseases? 06/21/2020

No studies have shown that ALG14 is directly related to the occurrence of neurodegenerative diseases, but glycosylation plays a crucial role in the development and function of the nervous system, so it may be related to neurodegenerative diseases.

Which cell signaling molecules are involved in ALG14? 02/12/2020

The regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG13 and ALG1.

What are the effects of ALG14 inhibitors? 10/15/2019

Several inhibitors have been developed to target ALG14, including inhibiting its glycosylation activity and regulating its interactions with other glycosylated enzymes.

Customer Reviews (3)

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Reviews
10/26/2020

    Catalyze the hydrolysis of clindamycin phosphate to clindamycin, and make it play an antibiotic role.

    09/20/2019

      ALG14 had high purity and no obvious impurities.

      04/07/2019

        Can be detected by AGAR electrophoresis method, it is convenient.

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