ALG8

Alg8 protein is involved in n-biglycosylation and leads the control of n-glycosylation of single amido group, and is the key enzyme of glycosylation on the polypeptide chain.

The protein is mainly expressed in endoplasmic reticulum and plays an important role in glycosylation reaction on endoplasmic reticulum.

Alg8 protein plays an important role in a variety of biological and medical research, such as calcium ion transport, nervous system development and other fields.

Alg8 protein is involved in cell signal transduction because its glycosylation activity is involved in the regulation and control of many signaling pathways.

Alg8 protein plays an important role in many diseases, such as congenital heart disease, Crohn's disease, autoimmune diseases, vascular endothelial dysfunction and so on.

Through the endoplasmic reticulum, Alg8 protein enters the Golgi apparatus and its transport and distribution are detected by synchronous multi-infiltration method and electron microscopy. Vesicles and membranes that can enter the Golgi apparatus gradually form aggregation, and gradually separate and pass through the Golgi apparatus membrane with increasing density, and play a role in the cell membrane.

Alg8 protein may have appeared in plastid in ancient times, changed gradually with the evolution of organisms, and played an increasingly important role in the process of evolution.

Alg8 protein is widely expressed in many tissues and organs of the human body, and some studies have shown that there is a higher level of expression in liver, kidney and other organs.

Alg8 protein is one of many cell surface glycosylase, so it may be involved in the regulation and regulation of immune function.

Alg8 proteins belong to a family of transmembrane proteins that structurally contain an n-terminal signaling peptide, a transmembrane domain, a C-terminal extracellular group, and a set of highly conserved enzyme active sites.

Loss of Alg8 protein may cause birth defects, mental retardation, ataxia, and neurological disorders.

This protein plays a role in a variety of signaling pathways, including NF-κB signal, Jak/Stat signal, PI3K/Akt signal, etc., which may have a certain impact on the normal regulation and function of these pathways.

The Alg8 gene is located on chromosome 17p11.2 and contains 7 exons and 6 introns with a total length of 23 kb.

Changes in the expression level of Alg8 protein may affect the degree of cell glycosylation, and thus affect normal cell function and physiological processes.

The semantic ortholog of Alg8 protein is Drosophila melanogaster CG32815.

Alg8 protein has certain potential in anti-cancer therapy because it plays an important role in the process of cellular glycosylation, and studying its regulation in tumor cells may help to study the mechanism of cancer occurrence.

Alg8 protein is regulated by many factors, including transcription factors, RNA splicing and transformation, which affect the expression level and activity of Alg8.