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AMY2B

  • Official Full Name

    amylase, alpha 2B (pancreatic)

  • Overview

    Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and;thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several;amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase;isoenzyme produced by the pancreas.
  • Synonyms

    AMY2B; amylase, alpha 2B (pancreatic); AMY2, amylase, alpha 2B; pancreatic; alpha-amylase 2B; 1; 1,4-alpha-D-glucan glucanohydrolase; 1,4-alpha-D-glucan glucanohydrolase 2B; 4-alpha-D-glucan glucanohydrolase 2B; Alpha-amylase carcinoid; AMY2; AMY2B_HUMAN; amylase, alpha 2B; Amylase, pancreatic, alpha-2B; Carcinoid alpha-amylase; EC 3.2.1.1; Glycogenase; OTTHUMP00000012696;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Human Pancreas
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AMY2B-231H Recombinant Human AMY2B Protein, His-tagged HEK293 His
Human AMY2B-9630H Recombinant Human AMY2B, His-tagged E.coli His C-term-352a.a.
Human AMY2B-232H Recombinant Human AMY2B protein (Met1-Leu511), His-tagged HEK293 His
Human AMY2B-536H Recombinant Human AMY2B protein, GST-tagged Wheat Germ GST
Human AMY2B-8873HCL Recombinant Human AMY2B 293 Cell Lysate HEK293 N/A
Human AMY2B-294H Recombinant Human AMY2B Protein, Fc-tagged HEK293 Fc Met1-Leu511
Human AMY2B-1032HF Recombinant Full Length Human AMY2B Protein, GST-tagged In Vitro Cell Free System GST 511 amino acids
Human AMY2B-0084H Recombinant Human AMY2B Protein (Gln16-Leu511), C-His-tagged Mammalian cells C-His Gln16-Leu511
Human AMY2B-1858H Native Human Amylase, Alpha 2B (pancreatic) Human Pancreas N/A
Rhesus Macaque AMY2B-317R Recombinant Rhesus monkey AMY2B Protein, His-tagged Mammalian Cell His
Rhesus Macaque AMY2B-145R Recombinant Rhesus Macaque AMY2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AMY2B-145R-B Recombinant Rhesus Macaque AMY2B Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AMY2B Related Articles

AMY2B involved in several pathways and played different roles in them. We selected most pathways AMY2B participated on our site, such as Starch and sucrose metabolism, Metabolic pathways, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMY2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Starch and sucrose metabolismTREH;HK1;AMY2A4;KL;HK2;HKDC1;UGT2A3;PYGMA;AGLA
Metabolic pathwaysUROS;TDO2A;GCSHA;URAH;SAT2B;CYCSB;MTHFR;CKMT1B;MT-ATP6
Pancreatic secretionRYR2;FXYD2;ATP1B4;CELA3B;CA2;CLCA1;KCNMA1;AMY2A;CPB1
Carbohydrate digestion and absorptionHK1;GNAT3;PIK3CB;ATP1B2;ATP1B1;AMY2A4;FXYD2;AKT1;PIK3R5

AMY2B has several biochemical functions, for example, alpha-amylase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMY2B itself. We selected most functions AMY2B had, and list some proteins which have the same functions with AMY2B. You can find most of the proteins on our site.

Function Related Protein
alpha-amylase activityAMY2A;AMY2A3;AMY2A5;AMY2B;AMY2A2;AMY1B;AMY1A;Amy1;AMY2A4
metal ion bindingGZF1;NDUFS8;CIT;NEURL1B;CYP8B2;CYP1A;KCNIP3A;ZIM3;NRP1A

AMY2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMY2B here. Most of them are supplied by our site. Hope this information will be useful for your research of AMY2B.

FOS; tkt1

OMICHI, K; HASE, S; et al. DETECTION OF HUMAN URINARY ALPHA-AMYLASE ENCODED BY THE AMY2B GENE USING A FLUOROGENIC SUBSTRATE, FG5P. JOURNAL OF BIOCHEMISTRY 112:303-305(1992).
  • Q&As
  • Reviews

Q&As (14)

Ask a question
Are there any genetic variations or polymorphisms associated with the AMY2B gene? 12/04/2022

Yes, genetic variations and polymorphisms have been identified in the AMY2B gene. Similar to the AMY2A gene, the copy number of the AMY2B gene can vary among individuals. Some studies have suggested that individuals with higher AMY2B gene copy numbers may have a greater capacity for carbohydrate digestion and a lower risk of developing obesity and related metabolic disorders. However, further research is needed to fully understand the implications of these genetic variations on carbohydrate metabolism and health.

How does the AMY2B protein function in carbohydrate digestion? 08/09/2022

The AMY2B protein functions by catalyzing the hydrolysis of alpha-1,4-glucosidic linkages in carbohydrates. It specifically targets starch and glycogen, which are found in various foods, including grains, potatoes, and legumes. AMY2B starts the breakdown process in the mouth, where it is secreted in saliva, and continues its action in the small intestine. It breaks down the complex carbohydrates into simpler sugars, such as glucose and maltose, which can be absorbed and metabolized by the body.

Are there any health implications associated with AMY2B gene duplication or deletion? 02/22/2022

AMY2B gene duplication or deletion can potentially have health implications, although the exact consequences are still under investigation. Some studies have reported that individuals with higher AMY2B copy numbers may have a greater ability to digest and utilize starch, which could have implications for metabolic health and nutrient absorption.

Does the AMY2B protein have any other functions besides carbohydrate digestion? 01/25/2020

While the primary function of the AMY2B protein is the digestion of carbohydrates, it may have additional roles in the body. Some studies have suggested that amylase enzymes, including AMY2B, might also have antibacterial properties and be involved in innate immunity. However, the extent and significance of these potential functions of the AMY2B protein are not fully understood and require further research to elucidate.

Are there any known pharmacological interventions that target AMY2B for therapeutic purposes? 12/01/2018

Currently, there are no known pharmacological interventions specifically targeting AMY2B for therapeutic purposes. Most interventions related to carbohydrate digestion and metabolism primarily focus on digestive enzymes such as amylase or medications that affect glucose regulation, rather than directly targeting the AMY2B gene or its protein product. However, as research in this field continues to advance, it is possible that future therapeutic interventions may be developed to specifically target AMY2B and enhance carbohydrate metabolism.

What are the health implications of AMY2B gene variations or mutations? 10/19/2018

The health implications of AMY2B gene variations or mutations are not well-understood. However, disruptions or alterations in the AMY2B gene could potentially affect the efficiency of carbohydrate digestion and metabolism. It is possible that individuals with certain AMY2B gene variations or mutations may have reduced amylase activity, leading to difficulties in carbohydrate digestion and potential metabolic consequences. Further research is needed to determine the specific health implications of AMY2B gene variations.

Are there any therapeutic applications or implications of studying the AMY2B protein? 08/08/2018

Studying the AMY2B protein could have potential therapeutic applications and implications. A better understanding of AMY2B gene variation and its impact on carbohydrate digestion and metabolism could potentially lead to personalized dietary recommendations for individuals based on their genetic profile.

Is there any association between AMY2B gene variations and dietary adaptation? 10/26/2016

Yes, some studies have suggested an association between AMY2B gene variations and dietary adaptation. Specifically, there is evidence to suggest that populations with a long history of high-starch diets, such as those who traditionally consume agricultural or processed foods, may have higher AMY2B copy numbers. It is believed that these genetic variations have evolved as an adaptation to the increased consumption of starch-rich foods, allowing for more efficient carbohydrate digestion and utilization.

Are there any known interactions between AMY2B gene variations and gut microbiota? 09/13/2016

Research investigating the interactions between AMY2B gene variations and gut microbiota is emerging but still limited. Some studies have suggested that AMY2B gene copy number variations may influence the composition and function of the gut microbiota, which in turn can impact digestion and nutrient metabolism.

Can AMY2B gene variations be inherited? 09/07/2016

Yes, AMY2B gene variations can be inherited. The AMY2B gene is located on chromosome 1, and variations in this gene can be passed down from parents to their offspring. Some studies have suggested that AMY2B copy number variations show heritability patterns, meaning they can be inherited within families. However, the inheritance patterns and mechanisms of AMY2B gene variations are still not fully understood, and more research is needed to uncover the specifics of their hereditary nature.

Does AMY2B gene variation affect an individual's response to a high-carbohydrate or low-carbohydrate diet? 07/06/2016

The relationship between AMY2B gene variations and an individual's response to high-carbohydrate or low-carbohydrate diets is not fully understood. Some studies have examined the potential influence of AMY2B gene copy numbers on dietary responses and found that individuals with higher AMY2B copy numbers may have a more favorable response to high-carbohydrate diets in terms of insulin sensitivity and weight management.

Can changes in AMY2B expression or activity impact digestion and nutrient absorption? 05/13/2016

Yes, changes in AMY2B expression or activity can impact digestion and nutrient absorption. Reduced expression or activity of AMY2B may lead to inadequate digestion of carbohydrates, resulting in malabsorption of nutrients and potential digestive discomfort such as bloating or gas.

Are there any diseases or conditions associated with AMY2B gene mutations? 03/31/2016

At present, there is limited evidence to suggest specific diseases or conditions associated with AMY2B gene mutations. However, some studies have explored potential links between AMY2B gene variations and metabolic disorders such as obesity, diabetes, and metabolic syndrome.

How is AMY2B gene expression regulated? 02/05/2016

The regulation of AMY2B gene expression is not yet fully understood. However, some studies have investigated potential regulators of AMY2B expression. It has been suggested that dietary factors, such as the consumption of high-starch diets, may induce AMY2B gene expression. Additionally, certain signaling pathways and transcription factors, such as CREB, Foxo1, and HNF1α, may be involved in regulating AMY2B gene expression. Further research is needed to elucidate the precise mechanisms and factors that regulate AMY2B gene expression.

Customer Reviews (5)

Write a review
Reviews
08/30/2022

    the manufacturer's supply management capabilities assure a seamless and continuous provision of the AMY2B protein.

    05/06/2021

      The AMY2B protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.

      10/14/2018

        In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.

        08/23/2018

          Its purity, stability, and functionality make it an ideal choice for my research endeavors.

          01/24/2018

            With their meticulous documentation and support, I am confident that my utilization of AMY2B protein in clinical trials will meet all necessary regulations and guidelines.

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