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ANKRD1

  • Official Full Name

    ankyrin repeat domain 1 (cardiac muscle)

  • Overview

    The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.
  • Synonyms

    ANKRD1; ankyrin repeat domain 1 (cardiac muscle); ankyrin repeat domain-containing protein 1; ALRP; C 193; CARP; CVARP; MCARP; bA320F15.2; ANKR1_HUMAN; ANKRD 1; Ankyrin repeat domain containing protein 1; C193; Cardiac ankyrin repeat protein; Cytokine inducible nuclear protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein; HA1A2; Liver ankyrin repeat domain 1; OTTHUMP00000020084; C-193;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANKRD1-9663H Recombinant Human ANKRD1, GST-tagged E.coli GST 1-319a.a.
Human ANKRD1-7150H Recombinant Human Ankyrin Repeat Domain 1 (Cardiac Muscle), His-tagged E.coli His 1-319aa
Human ANKRD1-235H Recombinant Human ANKRD1 protein, T7/His-tagged E.coli T7/His
Human ANKRD1-570H Recombinant Human ANKRD1 protein, GST-tagged Wheat Germ GST
Human ANKRD1-8858HCL Recombinant Human ANKRD1 293 Cell Lysate HEK293 N/A
Human ANKRD1-1222HF Recombinant Full Length Human ANKRD1 Protein, GST-tagged In Vitro Cell Free System GST 319 amino acids
Human ANKRD1-586H Recombinant Human ANKRD1 Protein, His-tagged E.coli His Val6~Leu291
Mouse Ankrd1-587M Recombinant Mouse Ankrd1 Protein, His-tagged E.coli His Met1~Phe319
Rat ANKRD1-673R Recombinant Rat ANKRD1 Protein Mammalian Cell His
Rat ANKRD1-329R-B Recombinant Rat ANKRD1 Protein Pre-coupled Magnetic Beads HEK293
Rat ANKRD1-329R Recombinant Rat ANKRD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ankrd1-588R Recombinant Rat Ankrd1 Protein, His/GST-tagged E.coli His/GST Arg5~Asn279
Chicken ANKRD1-5975C Recombinant Chicken ANKRD1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANKRD1 Related Articles

ANKRD1 involved in several pathways and played different roles in them. We selected most pathways ANKRD1 participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism, Hypertrophy Model, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKRD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid, triacylglycerol, and ketone body metabolismACSF3;THEM5;ACOT10;MED10;ACOT12;ACOT11A;ACOT11;MED19;MMAA
Hypertrophy ModelZEB1B;WDR1;CYR61;DUSP14;MSTN;MSTNB;IFRD1;ADAM10A;ANKRD1
MetabolismCPNE3;ECI1;FMODA;YAP1;APOA5;CA5B;GSTO2;SACM1L;Agmo
Metabolism of lipids and lipoproteinsFA2H;G0S2;YAP1;PTGDSA;APOA4B.1;MED31;SGMS2;CYP2V1;ARSK
PPARA activates gene expressionGLIPR1;CDK19;MED31;G0S2;MED23;ANKRD1;MED7;SREBF2;APOA5
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)MED16;MED25;MTF1;GLIPR1;MED9;MED22;MED18;CTGF;MED21

ANKRD1 has several biochemical functions, for example, DNA binding, R-SMAD binding, RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANKRD1 itself. We selected most functions ANKRD1 had, and list some proteins which have the same functions with ANKRD1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingEGR1;ETS1;ZNF26;DNASE1L2;DRAP1;RNF11;MEF2CA;FUS;HIST1H2BM
R-SMAD bindingSMURF1;PPM1A;ANKRD1;SMAD3;CTNNB1;MYOCD;ZEB2;FOS;SMAD6
RNA polymerase II transcription coactivator activitySOX12;PHF17;TRIM28;CITED4;HYAL2;MED12L;PSIP1;MYOCD;ANKRD1
RNA polymerase II transcription factor bindingSMAD4;TAL1;GATA2B;MTDH;GSC;ZFPM1;TBX6;GSK3B;GATA3
histone deacetylase bindingDDX20;DNMT3B;HDAC1;NACC2;HDAC9;PARK2;PKN1;NIPBL;RAD9
p53 bindingCDKN2A;TAF3;TP53;BANP;BCL2L12;SMYD2;MDM2;ZMAT4;TRIM24
protein bindingHSPB2;CDA;Ccl27a;APOBEC3F;NUDT22;DNMBP;IFT43;ANGPT1;RBM44
titin bindingCALM1;ANKRD2;CALM;SLC14A2;CALM2;MYBPC1;ANKRD1;TRIM63;OBSCN
transcription corepressor activityUBP1;TMEM38A;BRD7;DDX54;HOMEZB;ANKRD1;TBL1XR1;C1D;HDAC5

ANKRD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKRD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKRD1.

PDE4DIP; DNAJB6; TULP3; DYSF; MYL1; LRPPRC; ARHGDIB; MYOM2; MYBPC1; DST; TTN; REPS1; ASH2L; APPL1

Min, CK; Kwon, YJ; et al. Multiple Orientia tsutsugamushi Ankyrin Repeat Proteins Interact with SCF1 Ubiquitin Ligase Complex and Eukaryotic Elongation Factor 1 alpha. PLOS ONE 9:-(2014).
Tiede, C; Tang, AAS; et al. Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications. PROTEIN ENGINEERING DESIGN & SELECTION 27:145-155(2014).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
Are there any known interactors of ANKRD1 that affect its function? 04/10/2023

Yes, several interactors of ANKRD1 have been identified that influence its function. For example, ANKRD1 has been found to interact with titin, a protein responsible for muscle elasticity. This interaction is thought to regulate the mechanical properties of cardiac muscle. ANKRD1 also interacts with transcription factors like GATA4 and MEF2, modulating their transcriptional activity and the expression of target genes involved in muscle development and function.

Is ANKRD1 expressed in tissues other than the heart and skeletal muscles? 03/23/2023

While ANKRD1 is predominantly expressed in the heart and skeletal muscles, it has also been detected in other tissues like smooth muscles, lung, kidney, and testis, albeit at lower levels. Its tissue-specific expression patterns suggest diverse functions for ANKRD1 outside of cardiac and skeletal muscle physiology.

What other proteins interact with ANKRD1? 12/11/2022

ANKRD1 has been reported to interact with several proteins, including transcription factors such as GATA4 and MEF2, structural proteins like titin and myosin, and other regulatory molecules involved in cardiac stress response and gene expression pathways.

Are there any therapeutic implications of ANKRD1? 12/12/2021

The potential therapeutic implications of ANKRD1 are being investigated. Since ANKRD1 is involved in muscle regeneration and the response to cardiac stress, targeting this protein could potentially be beneficial in the treatment of muscle-related disorders, such as muscular dystrophy or cardiac diseases. However, specific strategies for targeting ANKRD1 are still under investigation.

Is ANKRD1 only expressed in striated muscle cells? 01/19/2021

No, ANKRD1 expression is not limited to striated muscle cells. While it is predominantly expressed in striated muscles, such as cardiac and skeletal muscles, ANKRD1 has also been found in other tissues and cell types. For example, it has been detected in smooth muscle cells, osteoblasts, fibroblasts, and certain cancer cells. This suggests that ANKRD1 may have additional roles beyond muscle-related functions.

Can ANKRD1 be used as a biomarker for certain diseases? 10/26/2020

ANKRD1 has been proposed as a potential biomarker for certain diseases. For example, increased expression of ANKRD1 has been observed in patients with heart failure and dilated cardiomyopathy, suggesting its potential as a diagnostic or prognostic marker for these conditions. However, further research is needed to determine its clinical utility as a biomarker.

What are the different isoforms of ANKRD1 protein? 12/12/2019

ANKRD1 has several isoforms due to alternative splicing. The isoforms vary in their ability to interact with other proteins and may have different tissue-specific expression patterns.

How is ANKRD1 related to cardiac remodeling? 12/28/2018

ANKRD1 plays a crucial role in cardiac remodeling processes. It is involved in the response of the heart to stress and injury. Upregulation of ANKRD1 expression has been observed in cardiac hypertrophy, a compensatory response to increased workload. ANKRD1 helps regulate the balance between growth and remodeling in the heart, influencing its structure and function.

Is ANKRD1 involved in other cellular processes besides muscle-related functions? 08/25/2018

Yes, while ANKRD1 is primarily associated with muscle-related functions, it has also been implicated in other cellular processes. For example, ANKRD1 has been shown to play a role in osteoblast differentiation and bone formation. It is involved in the regulation of gene expression related to osteogenesis, suggesting its involvement in skeletal development and maintenance.

Can ANKRD1 expression be altered by external factors? 05/31/2018

Yes, ANKRD1 expression can be influenced by external factors. For example, exercise has been shown to increase ANKRD1 expression in skeletal and cardiac muscles. Mechanical stress and hypertrophic stimuli can also upregulate ANKRD1 expression. Additionally, certain drugs and signaling molecules can modulate ANKRD1 expression levels in muscle cells.

Can ANKRD1 be regulated by post-translational modifications? 02/21/2018

Yes, ANKRD1 can be regulated by post-translational modifications. Phosphorylation of ANKRD1 has been reported and can impact its protein stability and localization. For example, phosphorylation of ANKRD1 by protein kinase D1 (PKD1) induces its translocation to the nucleus and enhances its transcriptional activity. Other post-translational modifications, such as acetylation and sumoylation, have also been suggested to influence the function of ANKRD1.

Is ANKRD1 conserved across different species? 02/01/2018

Yes, ANKRD1 is highly conserved across different species, including mammals, birds, reptiles, and fish. This conservation suggests its important physiological role throughout evolution. The protein sequence and functional domains of ANKRD1 are well conserved, indicating its fundamental importance in various biological processes.

Is ANKRD1 involved in muscle regeneration? 11/28/2017

Yes, ANKRD1 is known to play a role in muscle regeneration. During muscle injury or regeneration processes, ANKRD1 expression is upregulated, and it helps in the activation of muscle satellite cells, which are responsible for muscle repair and regeneration. ANKRD1 may regulate the differentiation and activation of these satellite cells.

Are there any diseases or conditions associated with ANKRD1 mutations? 07/25/2017

Mutations or genetic variants in the ANKRD1 gene have been linked to certain cardiovascular diseases. For example, a mutation in ANKRD1 has been identified in patients with dilated cardiomyopathy, a condition characterized by the enlargement of the heart chambers and reduced cardiac function. Additionally, alterations in ANKRD1 expression have been found in cardiac hypertrophy, heart failure, and arrhythmias.

Is ANKRD1 involved in any signaling pathways? 01/04/2017

Yes, ANKRD1 is known to participate in several signaling pathways. For instance, it has been shown to interact with the MAPK signaling pathway, specifically with members of the mitogen-activated protein kinase kinase kinase (MAP3K) family. This interaction suggests that ANKRD1 may play a role in modulating MAPK signaling and subsequent cellular responses.

Are there any animal models used to study ANKRD1? 10/18/2016

Animal models have been used to study the role of ANKRD1 in various biological processes. For example, ANKRD1 knockout mice have been generated to understand the protein's function in cardiac development and function. These mice have shown abnormalities in heart structure and function, providing insights into the importance of ANKRD1 in cardiac physiology.

Is ANKRD1 associated with any diseases? 09/28/2016

ANKRD1 has been implicated in various diseases and disorders. Mutations or dysregulation of ANKRD1 have been linked to skeletal muscle-related conditions, including muscular dystrophy and myopathies. Additionally, altered expression of ANKRD1 has been observed in heart failure, dilated cardiomyopathy, and certain types of cancer. These associations highlight the potential role of ANKRD1 in disease pathogenesis.

Can ANKRD1 be used as a therapeutic target? 09/14/2016

The potential of targeting ANKRD1 for therapeutic purposes is currently under investigation. Given its involvement in muscle-related disorders and its role in cardiac stress response, modulating ANKRD1 activity or expression may hold promise for the treatment of certain diseases. However, more research is needed to fully understand the mechanisms of ANKRD1 and evaluate its suitability as a therapeutic target.

Can ANKRD1 be used as a biomarker? 04/23/2016

ANKRD1 has been investigated as a potential biomarker for detecting cardiac damage and predicting patient outcomes in certain cardiovascular disease conditions, such as heart failure. However, more research is needed to define its precise role as a biomarker.

Are there any drugs or treatments that target ANKRD1? 03/03/2016

Currently, there are no specific drugs or treatments that directly target ANKRD1. However, ongoing research on the protein may provide insights into potential therapeutic strategies for cardiac diseases associated with ANKRD1 dysregulation.

Customer Reviews (4)

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Reviews
05/23/2022

    With the ANKRD1protein and the manufacturer's support, I am confident in obtaining accurate and meaningful results for my scientific investigations.

    03/10/2020

      Its purity, stability, and consistency ensure reliable and reproducible results, giving me confidence in the integrity of my research findings.

      09/23/2019

        With their assistance, I can overcome obstacles and optimize my experimental setup.

        09/04/2016

          Their experienced team is dedicated to resolving any issues or challenges I may encounter during my experiments, providing prompt and effective solutions.

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