ANKS3
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Official Full Name
ankyrin repeat and sterile alpha motif domain containing 3
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Synonyms
ANKS3; ankyrin repeat and sterile alpha motif domain containing 3; ankyrin repeat and SAM domain-containing protein 3; FLJ32345; FLJ32767; KIAA1977;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ANKS3 involved in several pathways and played different roles in them. We selected most pathways ANKS3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ANKS3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ANKS3 itself. We selected most functions ANKS3 had, and list some proteins which have the same functions with ANKS3. You can find most of the proteins on our site.
Function | Related Protein |
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ANKS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKS3.
GFI1B
- Q&As
- Reviews
Q&As (11)
Ask a questionAt present, there is limited information regarding animal models or knockout studies specifically targeting ANKS3. Animal models, such as mice with targeted deletions or mutations in the ANKS3 gene, could provide valuable insights into its physiological functions and potential roles in disease. However, further research is needed to generate these models and investigate their phenotypes.
As of now, there are no known drugs or compounds specifically developed to target ANKS3 or modulate its activity. However, considering ANKS3's potential involvement in cellular processes related to RhoA signaling, molecules that target RhoA or its downstream effectors may indirectly influence ANKS3 activity. Further research may identify small molecules, peptides, or other targeted therapies that can directly modulate ANKS3 function.
While the exact cellular and physiological processes regulated by ANKS3 are not fully understood, some studies have suggested its involvement in cell migration, cytoskeletal organization, and signaling pathways related to RhoA activity. ANKS3 might play a role in modulating cellular processes that depend on RhoA-mediated signaling, such as cell adhesion, cell shape changes, and actin cytoskeleton dynamics. However, more research is needed to elucidate the precise functions of ANKS3 in specific cellular processes.
Limited information is available regarding genetic variants or mutations in the ANKS3 gene and their association with specific human diseases. The potential involvement of ANKS3 in cancer, as suggested by dysregulated expression in certain cancer types, leaves open the possibility of genetic alterations in ANKS3 contributing to disease development or progression. However, further studies, including genome-wide association studies (GWAS) and deep sequencing analysis, are necessary to identify and characterize ANKS3 genetic variants associated with human diseases.
As of now, there are no known genetic disorders specifically linked to ANKS3 mutations. However, it is important to note that the understanding of ANKS3 is still relatively limited, and further research may uncover its potential roles in disease development or genetic disorders.
Currently, there is limited evidence linking ANKS3 to specific diseases or pathological conditions. However, ANKS3 expression has been observed to be dysregulated in certain cancer types, including colorectal cancer and hepatocellular carcinoma. The functional implications of ANKS3 dysregulation and its potential role in cancer development or progression require further investigation. Moreover, future studies may uncover additional disease associations or pathological conditions related to ANKS3.
Currently, there are no reported therapeutic implications specifically targeting ANKS3. However, if future research establishes important functional roles for ANKS3 in specific cellular processes or signaling pathways, targeting ANKS3 or its downstream effectors could potentially have therapeutic implications for diseases or conditions related to those pathways.
Yes, ANKS3 has been reported to interact with several proteins. One known protein interaction is with the RhoA GTPase, as mentioned earlier. ANKS3 can bind to the activated form of RhoA and modulate its activity. Other potential protein interactions include interactions with other members of the ANKS family, as well as proteins involved in signal transduction pathways, cell adhesion, and cytoskeleton organization. Further research is needed to fully characterize the protein interactome of ANKS3.
The expression pattern of ANKS3 seems to be tissue-specific. Some studies have reported its expression in various tissues, including the brain, heart, and adipose tissue. However, further investigation is needed to fully understand the specific tissue and cell type expression patterns of ANKS3.
ANKS3 has been reported to interact with several proteins, including RhoA and ROCK1, as mentioned earlier. Additionally, ANKS3 has been shown to associate with ZO-1, a scaffold protein involved in cell junctions, and the actin-binding protein cortactin. These interactions suggest potential roles for ANKS3 in regulating actin dynamics and cell adhesion. Further research may identify additional protein interactors of ANKS3, providing insight into its molecular interactions and cellular functions.
ANKS3 has been implicated in the regulation of RhoA signaling, a critical pathway involved in many cellular processes such as cytoskeletal organization, cell migration, and cell polarity. ANKS3 interacts with RhoA and its downstream effector ROCK1, suggesting a potential role in modulating RhoA-mediated signaling cascades. Further characterization is necessary to fully understand the extent of ANKS3's involvement in signaling pathways.
Customer Reviews (4)
Write a reviewTheir assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.
Whether I am studying protein interactions, cellular localization, or signaling pathways, the ANKS3 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.
Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.
the ANKS3 protein's compatibility with various experimental techniques further supports its usability.
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