Recombinant Human AP4B1 protein, GST-tagged
Cat.No. : | AP4B1-661H |
Product Overview : | Human AP4B1 full-length ORF ( ADZ15510.1, 1 a.a. - 739 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 81.3 kDa |
AA Sequence : | MPYLGSEDVVKELKKALCNPHIQAD RLRYRNVIQRVIRYMTQGLDMSGVF MEMVKASATVDIVQKKLVYLYMCTY APLKPDLALLAINTLCKDCSDPNPM VRGLALRSMCSLRMPGVQEYIQQPI LNGLRDKASYVRRVAVLGCAKMHNL HGDSEVDGALVNELYSLLRDQDPIV VVNCLRSLEEILKQEGGVVINKPIA HHLLNRMSKLDQWGQAEVLNFLLRY QPRSEEELFDILNLLDSFLKSSSPG VVMGATKLFLILAKMFPHVQTDVLV RVKGPLLAACSSESRELCFVALCHV RQILHSLPGHFSSHYKKFFCSYSEP HYIKLQKVEVLCELVNDENVQQVLE ELRGYCTDVSADFAQAAIFAIGGIA RTYTDQCVQILTELLGLRQEHITTV VVQTFRDLVWLCPQCTEAVCQALPG CEENIQDSEGKQALIWLLGVHGERI PNAPYVLEDFVENVKSETFPAVKME LLTALLRLFLSRPAECQDMLGRLLY YCIEEEKDMAVRDRGLFYYRLLLVG IDEVKRILCSPKSDPTLGLLEDPAE RPVNSWASDFNTLVPVYGKAHWATI SKCQGAERCDPELPKTSSFAASGPL IPEENKERVQELPDSGALMLVPNRQ LTADYFEKTWLSLKVAHQQVLPWRG EFHPDTLQMALQVVNIQTIAMSRAG SRPWKAYLSAQDDTGCLFLTELLLE PGNSEMQISVKQNEARTETLNSFIS VLETVIGTIEEIKS |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AP4B1 adaptor-related protein complex 4, beta 1 subunit [ Homo sapiens ] |
Official Symbol : | AP4B1 |
Synonyms : | AP4B1; adaptor-related protein complex 4, beta 1 subunit; spastic paraplegia 47 , SPG47; AP-4 complex subunit beta-1; beta 4 subunit of AP 4; BETA 4; beta4-adaptin; spastic paraplegia 47; beta 4 subunit of AP-4; CPSQ5; SPG47; BETA-4; |
Gene ID : | 10717 |
mRNA Refseq : | NM_001253852 |
Protein Refseq : | NP_001240781 |
MIM : | 607245 |
UniProt ID : | Q9Y6B7 |
Products Types
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (19)
Ask a questionAP4B1 is involved in intracellular protein transport and transport, and plays an important role in maintaining cell function.
Studies targeting the AP4B1 are actively underway to explore its function, mechanism of action, and potential therapeutic applications.
A number of related research projects have been carried out targeting the AP4B1 to understand its role in disease and potential therapeutic strategies.
Because there are currently no approved drugs, the side effects of AP4B1 are not fully understood.
At present, there are no reports on the crystal structure analysis of AP4B1 , which needs future research efforts.
The AP4B1 can interact with other proteins to form complexes that regulate cellular function.
There are currently no approved drugs targeting the AP4B1, but research is ongoing.
At present, there are no published clinical trial results on AP4B1 , which is the focus of future research.
As no related drugs have been approved yet, the feasibility of oral administration of AP4B1 needs to be further investigated.
Gene editing technology can be used to regulate the expression of AP4B1 , but further studies are needed to verify its feasibility and effect.
The recombinant AP4B1 protein has been implicated in several neurological diseases, such as neurodegenerative diseases and epilepsy.
At present, there are no reports on the application of AP4B1 in clinical cases, which is an area to be studied and developed.
The AP4B1 has a specific three-dimensional structure, including helix and folding, which plays an important role in its function.
Drugs targeting the AP4B1 are expected to take a long time to become available, as related research and clinical trials are still ongoing.
No clear studies have been reported on the relationship between AP4B1 and the immune system, which is an area of further study and we can look forward to future discoveries.
The recombinant AP4B1 protein has the potential to be used as a novel drug target in the clinical treatment of its related diseases.
Recombinant protein AP4B1 plays an important role in regulating nervous system function and cell signaling, and may be related to the occurrence and development of nervous system diseases.
At present, there are no reports on the development of specific antibodies against AP4B1 , which is the future research direction.
Recombinant AP4B1 proteins are usually synthesized using genetic engineering techniques to produce s by expressing the AP4B1 gene in cells.
Customer Reviews (4)
Write a reviewUnder different environmental conditions, the stability of AP4B1 is still very good, indicating that it has a wide range of applicability and stability.
AP4B1 showed good solubility in Western blot and can be easily dissolved in various buffers.
Short half-life and high clearance of AP4B1 make its effect more rapid and short, and can quickly achieve the therapeutic effect.
Experimenting with this AP4B1 allows me to more easily perform experimental operations without having to worry about reproducibility of experimental results.
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