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Recombinant Human AP4B1 protein, GST-tagged

Cat.No. : AP4B1-661H
Product Overview : Human AP4B1 full-length ORF ( ADZ15510.1, 1 a.a. - 739 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 81.3 kDa
AA Sequence : MPYLGSEDVVKELKKALCNPHIQAD RLRYRNVIQRVIRYMTQGLDMSGVF MEMVKASATVDIVQKKLVYLYMCTY APLKPDLALLAINTLCKDCSDPNPM VRGLALRSMCSLRMPGVQEYIQQPI LNGLRDKASYVRRVAVLGCAKMHNL HGDSEVDGALVNELYSLLRDQDPIV VVNCLRSLEEILKQEGGVVINKPIA HHLLNRMSKLDQWGQAEVLNFLLRY QPRSEEELFDILNLLDSFLKSSSPG VVMGATKLFLILAKMFPHVQTDVLV RVKGPLLAACSSESRELCFVALCHV RQILHSLPGHFSSHYKKFFCSYSEP HYIKLQKVEVLCELVNDENVQQVLE ELRGYCTDVSADFAQAAIFAIGGIA RTYTDQCVQILTELLGLRQEHITTV VVQTFRDLVWLCPQCTEAVCQALPG CEENIQDSEGKQALIWLLGVHGERI PNAPYVLEDFVENVKSETFPAVKME LLTALLRLFLSRPAECQDMLGRLLY YCIEEEKDMAVRDRGLFYYRLLLVG IDEVKRILCSPKSDPTLGLLEDPAE RPVNSWASDFNTLVPVYGKAHWATI SKCQGAERCDPELPKTSSFAASGPL IPEENKERVQELPDSGALMLVPNRQ LTADYFEKTWLSLKVAHQQVLPWRG EFHPDTLQMALQVVNIQTIAMSRAG SRPWKAYLSAQDDTGCLFLTELLLE PGNSEMQISVKQNEARTETLNSFIS VLETVIGTIEEIKS
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : AP4B1 adaptor-related protein complex 4, beta 1 subunit [ Homo sapiens ]
Official Symbol : AP4B1
Synonyms : AP4B1; adaptor-related protein complex 4, beta 1 subunit; spastic paraplegia 47 , SPG47; AP-4 complex subunit beta-1; beta 4 subunit of AP 4; BETA 4; beta4-adaptin; spastic paraplegia 47; beta 4 subunit of AP-4; CPSQ5; SPG47; BETA-4;
Gene ID : 10717
mRNA Refseq : NM_001253852
Protein Refseq : NP_001240781
MIM : 607245
UniProt ID : Q9Y6B7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (19)

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How does AP4B1 participate in cellular processes? 10/11/2022

AP4B1 is involved in intracellular protein transport and transport, and plays an important role in maintaining cell function.

What is the research progress on AP4B1? 07/20/2022

Studies targeting the AP4B1 are actively underway to explore its function, mechanism of action, and potential therapeutic applications.

Are there any existing research projects related to AP4B1 ? 05/29/2022

A number of related research projects have been carried out targeting the AP4B1 to understand its role in disease and potential therapeutic strategies.

May AP4B1 have side effects? 04/14/2022

Because there are currently no approved drugs, the side effects of AP4B1 are not fully understood.

Is there any crystal structure analysis of AP4B1 ? 03/09/2022

At present, there are no reports on the crystal structure analysis of AP4B1 , which needs future research efforts.

How does AP4B1 interact with other proteins? 01/06/2022

The AP4B1 can interact with other proteins to form complexes that regulate cellular function.

Are there any drugs that target recombinant AP4B1 that have been approved? 11/23/2021

There are currently no approved drugs targeting the AP4B1, but research is ongoing.

Are there any clinical trial results on recombinant AP4B1? 10/16/2021

At present, there are no published clinical trial results on AP4B1 , which is the focus of future research.

Can AP4B1 be used by oral administration? 05/31/2021

As no related drugs have been approved yet, the feasibility of oral administration of AP4B1 needs to be further investigated.

Can the expression of AP4B1 be regulated by gene editing technology? 05/17/2021

Gene editing technology can be used to regulate the expression of AP4B1 , but further studies are needed to verify its feasibility and effect.

Which diseases are associated with recombinant AP4B1? 03/12/2021

The recombinant AP4B1 protein has been implicated in several neurological diseases, such as neurodegenerative diseases and epilepsy.

Has AP4B1 been used in clinical cases? 01/16/2021

At present, there are no reports on the application of AP4B1 in clinical cases, which is an area to be studied and developed.

What are the structural properties of AP4B1 ? 08/12/2020

The AP4B1 has a specific three-dimensional structure, including helix and folding, which plays an important role in its function.

How soon can drugs targeting recombinant AP4B1 be available? 02/28/2020

Drugs targeting the AP4B1 are expected to take a long time to become available, as related research and clinical trials are still ongoing.

What is the relationship between AP4B1 and immune system? 12/22/2019

No clear studies have been reported on the relationship between AP4B1 and the immune system, which is an area of further study and we can look forward to future discoveries.

What is the clinical application value of AP4B1 ? 12/20/2019

The recombinant AP4B1 protein has the potential to be used as a novel drug target in the clinical treatment of its related diseases.

What is the role of AP4B1 in neurological diseases? 03/15/2019

Recombinant protein AP4B1 plays an important role in regulating nervous system function and cell signaling, and may be related to the occurrence and development of nervous system diseases.

Have specific antibodies against AP4B1 been developed? 01/29/2019

At present, there are no reports on the development of specific antibodies against AP4B1 , which is the future research direction.

What is the synthesis method of AP4B1 ? 01/11/2019

Recombinant AP4B1 proteins are usually synthesized using genetic engineering techniques to produce s by expressing the AP4B1 gene in cells.

Customer Reviews (4)

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Reviews
09/11/2021

    Under different environmental conditions, the stability of AP4B1 is still very good, indicating that it has a wide range of applicability and stability.

    11/21/2020

      AP4B1 showed good solubility in Western blot and can be easily dissolved in various buffers.

      08/30/2019

        Short half-life and high clearance of AP4B1 make its effect more rapid and short, and can quickly achieve the therapeutic effect.

        05/31/2019

          Experimenting with this AP4B1 allows me to more easily perform experimental operations without having to worry about reproducibility of experimental results.

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