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APBB1

  • Official Full Name

    amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)

  • Overview

    The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the;nucleus. It interacts with the Alzheimers disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1;and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent;the gene products nuclear translocation. This encoded protein could play an important role in the pathogenesis of;Alzheimers disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by;downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different;isoforms have been described for this gene.
  • Synonyms

    APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); RIR; amyloid beta A4 precursor protein-binding family B member 1; Fe65; stat-like protein; adaptor protein FE65a2; MGC:9072;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APBB1-668H Recombinant Human APBB1 protein, GST-tagged Wheat Germ GST
Human APBB1-8803HCL Recombinant Human APBB1 293 Cell Lysate HEK293 N/A
Human APBB1-8804HCL Recombinant Human APBB1 293 Cell Lysate HEK293 N/A
Human APBB1-33HF Recombinant Full Length Human APBB1 Protein In Vitro Cell Free System 708 amino acids
Human APBB1-1655H Recombinant Human APBB1 protein, His & T7-tagged E.coli His/T7 Gly267~Phe528 (Accession # O00213)
Human APBB1-28167TH Recombinant Human APBB1 Wheat Germ N/A 708 amino acids
Human APBB1-2405H Recombinant Human APBB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human APBB1-1079HF Recombinant Full Length Human APBB1 Protein, GST-tagged In Vitro Cell Free System GST 708 amino acids
Mouse APBB1-1757M Recombinant Mouse APBB1 Protein Mammalian Cell His
Mouse APBB1-615M Recombinant Mouse APBB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Apbb1-622M Recombinant Mouse Apbb1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse APBB1-615M-B Recombinant Mouse APBB1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Apbb1-199M Recombinant Mouse Apbb1 Protein, His-tagged E.coli N-His Pro182-Met412
Rat Apbb1-3437R Recombinant Rat Apbb1, His-tagged E.Coli or Yeast His 711
Rat APBB1-710R Recombinant Rat APBB1 Protein Mammalian Cell His
Rat APBB1-366R Recombinant Rat APBB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat APBB1-366R-B Recombinant Rat APBB1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

APBB1 involved in several pathways and played different roles in them. We selected most pathways APBB1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APBB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alzheimers diseaseNDUFA7;NDUFA10;NDUFC2;ATP5B;NDUFA1;APH1C;CALML3;NDUFV1;ATP5O

APBB1 has several biochemical functions, for example, beta-amyloid binding, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APBB1 itself. We selected most functions APBB1 had, and list some proteins which have the same functions with APBB1. You can find most of the proteins on our site.

Function Related Protein
beta-amyloid bindingFBXO2;MAPK8IP2;CD74;APBB2;CST3;BACE1;APBB3;ITM2C;LDLRAD3
chromatin bindingCBX7;SMARCC1;ARID3A;TCF7L1B;ATAD2;ING5;LMO2;HOXD10;BRD3
histone bindingMCM2;L3MBTL2;HIST2H3C1;HIST1H3G;ASF1B;WDTC1;SMARCA2;BRDT;NCAPD3
proline-rich region bindingBAIAP2;TCERG1;CYLD;CCND1;CSK;APBB1;RABAC1;GHR;FAM59A
protein bindingRTN4RL2A;GGNBP2;PSMB4;KIAA0947;CSNK2B;TNFSF13B;SH2D1A;SHROOM2;PRDM7
transcription factor bindingHES4;REST;E2F1;TFDP1B;GTF2A2;PELP1;JUND;NCOA2;HEY1

APBB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APBB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APBB1.

APP; LRP1; APP; EGFR; ERBB2; CLSTN1; ANXA1; App; ATXN1

  • Q&As
  • Reviews

Q&As (19)

Ask a question
Does APBB1 involve signal transduction pathways? 11/24/2022

APBB1 are involved in mitochondrial and Wnt signaling pathways.

What is the function and mechanism of APBB1 ? 11/23/2022

Recombinant APBB1 protein is a transcription factor associated with biological processes such as protein breakdown, signaling, and the cell cycle. Its main function is to participate in the regulation of transcription and RNA stability.

Is the APBB1 gene associated with genetic susceptibility to cancer? 07/31/2022

Mutations in the APBB1 gene are thought to be a risk gene for certain cancers and diseases such as Alzheimer's disease.

Is there gene tailoring of APBB1 in humans? If so, what is their molecular phenotype? 04/23/2022

The APBB1 gene is known to have multiple tailoring exons. In humans, there may be variable splicing of APBB1 gene.

Are there any drugs that target APBB1 ? If so, what is their mechanism of action? 04/01/2022

There are currently no drugs on the market that target the APBB1. At the same time, some researchers are exploring molecules related to APBB1 to develop drugs to treat diseases associated with it.

What is the mechanism of action of APBB1 in the treatment of Alzheimer's disease? 01/19/2022

APBB1 is involved in regulating the metabolism and transport of Alzheimer's disease-associated Aβ peptides and may be a therapeutic target for Alzheimer's disease.

In what diseases does recombinant APBB1 play an important role? 11/15/2021

The APBB1 has been studied in relation to many diseases, including Alzheimer's disease, cancer and cardiovascular disease.

In which organs is the expression of APBB1 high? 10/17/2021

APBB1 is highly expressed in tissues such as brain, heart and lung.

Has any study confirmed the correlation between APBB1 and the mutation of the gene encoding APP? 09/10/2021

Variations in both the APBB1 gene and the APP gene are considered risk genes for Alzheimer's disease.

What are the biological pathways associated with APBB1 ? 08/24/2021

APBB1 is associated with the amyloid precursor protein metabolic pathway (APP).

Is there any modern technology that can achieve the effect of treating and preventing related diseases by gene editing APBB1? 11/25/2020

The use of gene editing technology to study APBB1 to treat and prevent related diseases is a research hotspot in recent years.

Is there any research to prove that APBB1 can play an important role in anticancer therapy? 10/19/2020

APBB1 has been shown to be involved in a number of cell cycle and apoptosis pathways, so it may hold promise as a new target for cancer therapy.

Is there a specific antibody that can be used to detect APBB1 ? 09/21/2020

There are currently no specific antibodies available for the detection of APBB1 .

Are there any diseases associated with APBB1 gene mutation? If so, what are they? 12/21/2019

Mutations in the APBB1 gene are thought to be associated with diseases such as cancer and Alzheimer's disease.

What is the mechanism of action of APBB1 in cardiovascular disease? 09/08/2019

APBB1 is involved in signaling pathways in the occurrence and development of cardiovascular diseases such as myocardial hypertrophy and myocardial fibrosis.

Is APBB1 related to apoptosis? If so, what are their mechanisms? 06/28/2019

APBB1 may be involved in the regulation of apoptosis.

What is the role of APBB1 in tumor growth? 06/19/2019

APBB1 protein may act as a tumor inhibitor and participate in the regulation of cell cycle progression and apoptosis.

Are there any studies to control dementia symptoms associated with Alzheimer's disease by regulating the recombinant APBB1 protein? 04/15/2019

It has been shown that the impairment of cognitive function associated with Alzheimer's disease can be mitigated by regulating the APBB1.

Is there any research to prove that APBB1 can promote the regeneration of cardiovascular organs? 03/29/2019

At present, there are no studies to prove the mechanism of APBB1 promoting cardiovascular organ regeneration.

Customer Reviews (4)

Write a review
Reviews
12/08/2021

    APBB1 they produce has strong anti-pollution ability and is safe to use.

    02/21/2020

      Band position of APBB1 in Western blot was consistent with the expectation, showing good target recognition ability.

      12/14/2019

        Catalytic activity of APBB1 is very strong, which can significantly improve the yield of chemical reactions and reduce costs, and its economic value is outstanding.

        08/03/2019

          After using this APBB1, my experiment repeatability is very good, which is convenient for subsequent data analysis and experimental operation.

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