| Description : |
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
77 kDa |
| AA Sequence : |
MSVPSSLSQSAINANSHGGPALSLP LPLHAAHNQLLNAKLQATAVGPKDL RSAMGEGGGPEPGPANAKWLKEGQN QLRRAATAHRDQNRNVTLTLAEEAS QEPEMAPLGPKGLIHLYSELELSAH NAANRGLRGPGLIISTQEQGPDEGE EKAAGEAEEEEEDDDDEEEEEDLSS PPGLPEPLESVEAPPRPQALTDGPR EHSKSASLLFGMRNSAASDEDSSWA TLSQGSPSYGSPEDTDSFWNPNAFE TDSDLPAGWMRVQDTSGTYYWHIPT GTTQWEPPGRASPSQGSSPQEESQL TWTGFAHGEGFEDGEFWKDEPSDEA PMELGLKEPEEGTLTFPAQSLSPEP LPQEEEKLPPRNTNPGIKCFAVRSL GWVEMTEEELAPGRSSVAVNNCIRQ LSYHKNNLHDPMSGGWGEGKDLLLQ LEDETLKLVEPQSQALLHAQPIISI RVWGVGRDSGRDFAYVARDKLTQML KCHVFRCEAPAKNIATSLHEICSKI MAERRNARCLVNGLSLDHSKLVDVP FQVEFPAPKNELVQKFQVYYLGNVP VAKPVGVDVINGALESVLSSSSREQ WTPSHVSVAPATLTILHQQTEAVLG ECRVRFLSFLAVGRDVHTFAFIMAA GPASFCCHMFWCEPNAASLSEAVQA ACMLRYQKCLDARSQASTSCLPAPP AESVARRVGWTVRRGVQSLWGSLKP KRLGAHTPTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
