APEH
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Official Full Name
N-acylaminoacyl-peptide hydrolase
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Overview
This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. -
Synonyms
APEH; N-acylaminoacyl-peptide hydrolase; D3F15S2, D3S48E, DNF15S2; acylamino-acid-releasing enzyme; acyl-peptide hydrolase; acylaminoacyl-peptidase; oxidized protein hydrolase; APH; OPH; AARE; ACPH; D3S48E; D3F15S2; DNF15S2; MGC2178;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | APEH-676H | Recombinant Human APEH protein, GST-tagged | Wheat Germ | GST |
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| Human | APEH-26038TH | Recombinant Human APEH, His-tagged | E.coli | His |
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| Human | APEH-8798HCL | Recombinant Human APEH 293 Cell Lysate | HEK293 | N/A |
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| Human | APEH-1108HF | Recombinant Full Length Human APEH Protein, GST-tagged | In Vitro Cell Free System | GST | 732 amino acids |
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| Human | APEH-2527H | Recombinant Human APEH protein, His-tagged | E.coli | His | 1-732aa |
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| Rat | Apeh-3142R | Recombinant Rat Apeh, His-tagged | E.Coli or Yeast | His | 732 |
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| Rhesus Macaque | APEH-352R | Recombinant Rhesus monkey APEH Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | APEH-181R | Recombinant Rhesus Macaque APEH Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | APEH-181R-B | Recombinant Rhesus Macaque APEH Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | APEH-9860Z | Recombinant Zebrafish APEH | Mammalian Cell | His |
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| Chicken | APEH-2298C | Recombinant Chicken APEH | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- APEH Related Articles
APEH involved in several pathways and played different roles in them. We selected most pathways APEH participated on our site, such as Eukaryotic Translation Termination, Gene Expression, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with APEH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Eukaryotic Translation Termination | APEH;RPL35 |
| Gene Expression | ZNF398;ZNF483;ZNF285A;RORAA;ZNF227;SSRP1;NR6A1;PRDX2;ZNF747 |
| Metabolism of proteins | CCT7;APEH;NAPG;TRAPPC6A;PDIA6;ADD1;BCHE;ARSE;IGFBP4 |
| Translation | EEF1A2;EIF2B1;EEF1G;EEF1D;APEH;EEF1B2;EIF5 |
APEH has several biochemical functions, for example, omega peptidase activity, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APEH itself. We selected most functions APEH had, and list some proteins which have the same functions with APEH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| omega peptidase activity | JOSD1;USP5;ATXN3;GGH;JOSD2;APEH;ATXN3L;UCHL1;UCHL5 |
| poly(A) RNA binding | CPSF4;DUT;NOL12;PTCD3;SRP72;AASS;SMNDC1;SSRP1;CHST13 |
| protein binding | TAG-260;HIST2H3C;AZU1;Arid4b;RIPK1;PEX26;CSDC2;BTN3A1;L3MBTL3 |
| serine-type endopeptidase activity | PRSS54;PLAT;ELANE;PCSK4;KLK1B5;CORIN;KLK1B16;CTSC;TMPRSS3 |
APEH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APEH here. Most of them are supplied by our site. Hope this information will be useful for your research of APEH.
IST1; LGALS8; MCC; HLA-B; TMEM62; UBA5; 15-deoxy-delta(12,14
- Q&As
- Reviews
Q&As (10)
Ask a questionAt present, the side effects of APEH are relatively limited, and further clinical and scientific studies are needed to evaluate them.
APEH is a protein prepared by recombinant technology of human amino terminal hydrolase (APEH) gene.
APEH may be used to treat nervous system diseases by regulating neuronal function and alleviating nervous system inflammation.
At present, there are few clinical trial studies on APEH , and more data are needed to evaluate its safety and efficacy.
The APEH may affect the genesis and development of tumor by regulating the expression of tumor-related genes.
The preparation of APEH is mainly accomplished through the steps of gene cloning, expression and purification.
The latest research indicates that the APEH may have potential application value in the treatment of tumor and nervous system diseases.
APEH can participate in the biological processes of protein catabolism and amino acid release.
The of APEH has been studied in biochemistry, molecular biology, pharmacology and other fields.
APEH has potential clinical application value, and may play a role in the treatment of tumor and nervous system diseases.
Customer Reviews (4)
Write a reviewThe green production process of APEH is very advanced and adopts the most environmentally friendly production technology, which is worthy of vigorous promotion.
High clearance of APEH demonstrated its excellent pharmacokinetic characteristics and provided a new direction for biomedical research.
Clear banding and no impurity interference, showing its excellent purity and specificity.
Can maintain consistent performance every time it is used, which provides great convenience for experiments.
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