APIP
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Official Full Name
APAF1 interacting protein
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Overview
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 -
Synonyms
APIP; APAF1 interacting protein; probable methylthioribulose-1-phosphate dehydratase; APIP2; CGI 29; Mmrp19; MTRu-1-P dehydratase; APAF1-interacting protein; CGI29; CGI-29; dJ179L10.2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- Myc
- DDK
- GST
- His
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | APIP-682H | Recombinant Human APIP protein, GST-tagged | Wheat Germ | GST |
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| Human | APIP-6855H | Recombinant Human APAF1 Interacting Protein, His-tagged | E.coli | His | 1-242aa |
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| Human | APIP-9740H | Recombinant Human APIP, GST-tagged | E.coli | GST | 1-242a.a. | |
| Human | APIP-8795HCL | Recombinant Human APIP 293 Cell Lysate | HEK293 | N/A |
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| Human | APIP-416H | Recombinant Human APIP Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | C-Myc/DDK |
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| Human | APIP-1262HF | Recombinant Full Length Human APIP Protein, GST-tagged | In Vitro Cell Free System | GST | 242 amino acids |
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| Mouse | Apip-1660M | Recombinant Mouse Apip Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Zebrafish | APIP-1387Z | Recombinant Zebrafish APIP | Mammalian Cell | His |
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| Chicken | APIP-3191C | Recombinant Chicken APIP | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
APIP involved in several pathways and played different roles in them. We selected most pathways APIP participated on our site, such as Cysteine and methionine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with APIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cysteine and methionine metabolism | GOT2B;MAT1A;CBSB;GOT2A;CDO1;BCAT1;MPST;DNMT3A;MTR |
| Metabolic pathways | HPD;RDH10A;GALNT14;NDUFS8;BCMO1;ALOX8;NDUFAB1A;NT5C1A;NDUFA4L |
APIP has several biochemical functions, for example, identical protein binding, methylthioribulose 1-phosphate dehydratase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APIP itself. We selected most functions APIP had, and list some proteins which have the same functions with APIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | GNPNAT1;PFKL;TYROBP;MUL1;MCM6;COMMD1;REG3B;GDF5;CDC42BPA |
| methylthioribulose 1-phosphate dehydratase activity | |
| protein binding | PPM1F;PLP1;HOXB7;NINJ2;PPEF1;RG9MTD1;RBKS;CHRD;RBPMS2B |
| zinc ion binding | WBP7;RNF26;LIN28B;MORC4;PEX12;ZCCHC18;CLIP1;SYVN1;TRIM17 |
APIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APIP here. Most of them are supplied by our site. Hope this information will be useful for your research of APIP.
LNX1; NUDT18; SDCBP
- Q&As
- Reviews
Q&As (19)
Ask a questionThe recombinant Apip protein is low in immunogenicity and has not been found to produce any immune response to the body.
The recombinant Apip protein has potential applications in drug development and can be used to make drugs for the treatment of platelet dysfunction.
The physicochemical properties of Apip are a very stable protein that can adapt to a variety of pH values and temperatures.
Apip protein can be used to treat platelet dysfunction, influenza virus and other related diseases.
The Apip can be used to diagnose influenza virus infection by detecting the level of antibodies to the Apip .
Recombinant Apip protein can enhance the adhesion of platelets by activating the polymers on the surface of platelets, thus treating platelet dysfunction.
First, the target gene needs to be cloned into the expression vector, and then expressed in E. coli and other hosts, and the recombinant Apip protein can be obtained after purification and refolding.
The recombinant Apip protein has been clinically tested in patients as a drug for the treatment of platelet dysfunction, and the results show that it has some efficacy in the treatment of this disease.
Apip can maintain relative stability under the action of digestive enzymes such as stomach acid and pancreatic enzyme, and is not easy to be degraded.
The Apip differs from other similar molecules in that it is a highly stable protein that can remain intact under extreme conditions.
Clinical trials of Apip have shown a high safety profile without any serious adverse reactions.
The safety of Apip is very high, and no adverse effects on the body have been found in animal experiments.
Apip can be used in the production of antitoxins, vaccines and other fields.
Apip s are characterized by being more stable in high temperature and acid-base environments, which makes them more advantageous in some special application scenarios.
Recombinant Apip protein can significantly increase platelet count and shorten bleeding time and hemostasis time in animal experiments.
The production cost of Apip varies according to different factors such as production scale and process, and is generally at a moderate level.
The Apip is a very safe protein with low toxicity.
Apip can be used to cause diseases such as asthma, influenza, bronchitis and other models for the study of drugs to treat various related diseases.
The Apip is a very stable protein that can remain intact under extreme conditions such as acid-base environments and high temperatures.
Customer Reviews (5)
Write a reviewExperimenting with this Apip allows me to focus more on experimental design and data analysis without worrying about reproducibility of experimental results.
Production process of Apip is an environmental model and sets an example for the field of green production.
Under the action of various chemical agents or drugs, the stability of this protein is still very good, indicating that it has excellent anti-interference ability.
The lower limit of detection of Apip in Western blot is very low, and low concentration of target protein can be detected, indicating that it has the characteristics of high sensitivity and low detection limit.
This short half-life and high clearance characteristics make Apip have greater potential in the treatment of tumors, infections and other diseases.
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