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APOA4

  • Official Full Name

    apolipoprotein A-IV

  • Overview

    Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
  • Synonyms

    APOA4; apolipoprotein A-IV; apo-AIV; apoA-IV; apolipoprotein A4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Human Plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • His|T7
  • SUMO
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APOA4-766H Recombinant Human APOA4 Protein, His-tagged HEK293 His
Human APOA4-9749H Recombinant Human APOA4, GST-tagged E.coli GST 23-396a.a.
Human APOA4-30H Recombinant Human APOA4, His-tagged HEK293 His
Human APOA4-692H Recombinant Human APOA4 protein, GST-tagged Wheat Germ GST
Human APOA4-2037H Recombinant Human APOA4 protein, His & GST-tagged E.coli His/GST Glu21~Asn235 (Accession # P06727)
Human APOA4-8788HCL Recombinant Human APOA4 293 Cell Lysate HEK293 N/A
Human APOA4-1124HF Recombinant Full Length Human APOA4 Protein, GST-tagged In Vitro Cell Free System GST 396 amino acids
Human APOA4-1718H Recombinant Human APOA4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human APOA4-0598H Recombinant Human APOA4 Protein (Glu21-Ser396), N-His-tagged E.coli N-His Glu21-Ser396
Human ApoA4-68H Native Human Apolipoprotein AIV Human Plasma N/A
Human APOA4-4688H Recombinant Human APOA4 protein, His-tagged E.coli His 383aa
Human APOA4-2531H Recombinant Human APOA4 protein, His-SUMO-tagged E.coli His-SUMO 21-396aa
Human APOA4-2470H Recombinant Human APOA4 Protein (21-396 aa), His-tagged Yeast His 21-396 aa
Human APOA4-0597H Recombinant Human APOA4 Protein (Glu21-Ser396), C-His-tagged Mammalian cells C-His Glu21-Ser396
Mouse Apoa4-2039M Recombinant Mouse Apoa4 protein, His & S-tagged E.coli His/S Leu135~Asn281 (Accession # P06728)
Mouse APOA4-1782M Recombinant Mouse APOA4 Protein Mammalian Cell His
Mouse Apoa4-2038M Recombinant Mouse Apoa4 protein, His & S-tagged E.coli His/S Gln299~Ala369 (Accession # P06728)
Mouse APOA4-1332M Recombinant Mouse APOA4 Protein (21-395 aa), His-tagged Yeast His 21-395 aa
Mouse APOA4-628M-B Recombinant Mouse APOA4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Apoa4-632M Recombinant Mouse Apoa4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse APOA4-628M Recombinant Mouse APOA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Apoa4-2532M Recombinant Mouse Apoa4 protein, GST-tagged E.coli GST 21-395aa
Rat APOA4-719R Recombinant Rat APOA4 Protein Mammalian Cell His
Rat Apoa4-720R Recombinant Rat Apoa4 protein, His/GST-tagged E.coli His/GST Glu21~Ser391
Rat APOA4-375R Recombinant Rat APOA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat APOA4-375R-B Recombinant Rat APOA4 Protein Pre-coupled Magnetic Beads HEK293
Cattle APOA4-2036C Recombinant Cattle APOA4 protein, His & T7-tagged E.coli His/T7 Glu21~Gly380 (Accession # Q32PJ2)
Pig APOA4-3567P Recombinant Pig APOA4, His-tagged E.Coli or Yeast His 382
Pig APOA4-2040P Recombinant Pig APOA4 protein, His-tagged E.coli His Glu21~Gly382 (Accession # O46409)
Chicken APOA4-6498C Recombinant Chicken APOA4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APOA4 Related Articles
  • APOA4 Related Research Area

APOA4 involved in several pathways and played different roles in them. We selected most pathways APOA4 participated on our site, such as Fat digestion and absorption, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fat digestion and absorptionAGPAT2;PPAP2C;PLA2G2F;ABCA1;DGAT2;PLA2G3;PNLIP;AGPAT1;PLA2G2E
Vitamin digestion and absorptionAPOA1;FOLH1;SLC5A6;CUBN;SCARB1;RBP2;SLC19A3;LRAT;GIF

APOA4 has several biochemical functions, for example, antioxidant activity, cholesterol binding, cholesterol transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA4 itself. We selected most functions APOA4 had, and list some proteins which have the same functions with APOA4. You can find most of the proteins on our site.

Function Related Protein
antioxidant activityAPOA4;FAM213AA;UBIAD1;KDM3B;PRDX5;HP;TRP53INP1;SELS;CAT
cholesterol bindingOSBPL10;APOD;OSBPL8;ABCG1;APOA4A;APOA5;APOC3;OSBPL5;PTCH1
cholesterol transporter activityAPOE;APOA4B.2;APOA4;APOA5;APOA4B.1;APOEB;APOA1A;STAR;ABCA4
copper ion bindingADNP;SOD3A;S100A13;SCO2;LOXL5A;MOXD1;TRP53;ATP7A;ABHD1
lipid bindingCYTH4;ATP5G3;ACBD5;FFAR1;PPARD;NME4;APOL4;APOEB;STARD8
lipid transporter activityAPOM;APOBB.1;CETP;APOA4;MTP;APOA1A;APOD;VTG5;MTTP
phosphatidylcholine bindingCETP;PCTP;APOA1;APOA4;RPE65;APOA4A;NF1;APOA2;VPS24
phosphatidylcholine-sterol O-acyltransferase activator activityAPOEB;APOA4;APOA4A;APOA1;APOEA;APOA4B.1;APOA5;APOA2;APOE
protein bindingSTEAP3;ERCC3;PECAM1;GPR85;EIF3I;ALPI;KRTAP10-9;TRPM6;SORL1
protein homodimerization activityKIT;BOK;TCF12;DMRT3A;TPD52L1;TRIM9;ADIPOQ;TREX1;SLC11A1

APOA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA4.

NR1D1; d-mannose; g6pc_human_gene; ALB

Tokuhara, D; Nochi, T; et al. Specific Expression of Apolipoprotein A-IV in the Follicle-Associated Epithelium of the Small Intestine. DIGESTIVE DISEASES AND SCIENCES 59:2682-2692(2014).
Zhao, HH; Yang, F; et al. Label Free Proteome Analysis of Plasma from Unstable Angina with Blood Stasis Syndrome Patients. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 31:285-292(2010).
  • Q&As
  • Reviews

Q&As (17)

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Are there any therapeutic implications of targeting APOA4? 03/03/2023

Targeting APOA4 or its related pathways may have therapeutic implications in the management of metabolic disorders and cardiovascular diseases. Researchers are exploring the potential of using APOA4-based therapies for the treatment of dyslipidemia, atherosclerosis, and obesity. However, more studies are needed to fully understand the therapeutic potential and safety of such interventions.

Can APOA4 be used as a target for drug development? 10/06/2022

APOA4 has shown potential as a drug target for various metabolic conditions. Research has focused on developing therapeutics that can enhance APOA4's beneficial effects, such as increasing HDL cholesterol, improving lipid metabolism, and reducing inflammation. However, drug development targeting APOA4 is still in its early stages, and more research is required to explore its efficacy and safety.

Can APOA4 deficiency lead to any health complications? 09/11/2022

APOA4 deficiency has been associated with impaired lipid metabolism and increased susceptibility to metabolic abnormalities. Individuals with APOA4 deficiency may have altered lipid profiles, increased levels of circulating triglycerides, decreased levels of HDL cholesterol, and potentially an increased risk of developing cardiovascular diseases and related complications.

Can APOA4 levels be measured for diagnostic purposes? 08/08/2022

Currently, measuring APOA4 levels is not a routine diagnostic test. However, research investigating the association between APOA4 and various diseases may provide opportunities for its use as a diagnostic marker in the future. Measurement of APOA4 levels could potentially aid in identifying individuals at higher risk for cardiovascular disease or metabolic disorders.

Can APOA4 levels be influenced by diet and lifestyle? 03/03/2022

Yes, diet and lifestyle factors can influence APOA4 levels. Dietary fat intake, specifically monounsaturated and polyunsaturated fats, has been shown to increase APOA4 levels. Additionally, weight loss, dietary modifications, and physical activity can all have an impact on APOA4 levels, indicating that lifestyle interventions can modulate APOA4 expression.

What are the functions of APOA4? 11/03/2021

APOA4 has multiple functions in the body. It acts as a cofactor for various enzymes involved in lipid metabolism, assists in the assembly and secretion of triglyceride-rich lipoproteins, and regulates the absorption and transportation of dietary lipids. Additionally, APOA4 has antioxidant and anti-inflammatory properties.

How is APOA4 involved in the regulation of satiety and appetite? 04/26/2021

APOA4 has been found to play a role in the regulation of satiety and appetite. It has been proposed that APOA4 acts on specific brain regions involved in appetite control, influencing the release of neuropeptides that regulate hunger and food intake. Certain APOA4 variants have been associated with alterations in satiety signaling and increased hunger, potentially leading to overeating and obesity.

Is APOA4 associated with any specific diseases or conditions? 11/27/2020

APOA4 has been implicated in various diseases and conditions. Studies have suggested that alterations in APOA4 levels or function may contribute to dyslipidemia, obesity, insulin resistance, and cardiovascular diseases. Further research is needed to fully elucidate the role of APOA4 in these conditions and to determine if it could serve as a potential therapeutic target.

Is APOA4 involved in lipid transport within cells? 06/24/2019

While APOA4 is primarily involved in lipid transport in the bloodstream, recent research suggests its involvement in intracellular lipid transport as well. Studies have indicated that APOA4 is present in intracellular lipid droplets and may play a role in regulating lipid storage and metabolism within cells, although the exact mechanisms are still being elucidated.

Are there any genetic variations that influence APOA4 levels? 03/24/2019

Yes, genetic variations can influence APOA4 levels. Single nucleotide polymorphisms (SNPs) within the APOA4 gene have been identified and associated with variations in APOA4 levels. These genetic variations can impact APOA4 production, stability, or function, and may have implications for cardiovascular health and metabolic conditions. Studying these genetic variations can provide insights into individual differences in APOA4 biology and potential personalized treatment approaches.

Are there any known genetic variations or mutations in the APOA4 gene? 09/29/2018

Yes, genetic variations in the APOA4 gene have been reported. Certain single nucleotide polymorphisms (SNPs) in the APOA4 gene have been associated with altered lipid levels, cardiovascular disease risk, and obesity. Further research is necessary to fully understand the impact of these genetic variations on APOA4 function and disease susceptibility.

Can APOA4 levels be influenced by hormonal changes? 05/01/2018

Yes, hormonal changes can influence APOA4 levels. For example, estrogen has been shown to increase APOA4 production, which may contribute to the higher levels of circulating APOA4 observed in women compared to men. Hormonal fluctuations during the menstrual cycle and menopause can impact APOA4 levels, suggesting a hormonal regulation of APOA4 expression.

How can APOA4 levels be measured in the body? 01/21/2018

APOA4 levels can be measured in the body through various laboratory tests. One common method is to measure APOA4 concentrations in the blood using techniques such as enzyme-linked immunosorbent assay (ELISA) or immunoassays. These tests can provide quantitative measurements of APOA4 levels and help assess an individual's lipid profile and cardiovascular risk. It is typically performed as part of a lipid panel or comprehensive health assessment.

Can pharmacological interventions modify APOA4 levels? 12/20/2017

Currently, there are no specific pharmacological interventions available to directly modify APOA4 levels. However, interventions that target lipid metabolism, such as drugs that lower triglyceride levels or increase high-density lipoprotein (HDL) cholesterol, may indirectly impact APOA4 levels. Future research may identify pharmacological strategies aimed specifically at modulating APOA4 expression or function.

How is APOA4 involved in lipid metabolism? 12/14/2017

APOA4 has a significant role in lipid metabolism. It facilitates the binding of dietary triglycerides and cholesterol to form chylomicrons, which transport these lipids from the intestines to the bloodstream. APOA4 also assists in the breakdown of triglycerides through the activation of lipoprotein lipase, an enzyme that hydrolyzes triglycerides into fatty acids and glycerol for energy utilization.

Are there any lifestyle factors that can increase APOA4 levels? 09/15/2017

In addition to diet and physical activity, certain lifestyle factors have been associated with increased APOA4 levels. For instance, moderate alcohol consumption has been shown to elevate APOA4 levels in some studies. However, it is important to note that excessive alcohol consumption can have detrimental effects on overall health, outweighing any potential benefits on APOA4 levels.

Is APOA4 associated with any neurological disorders? 06/25/2016

Recent studies have suggested a potential link between APOA4 and neurological disorders such as Alzheimer's disease. In individuals carrying the APOE4 allele, which is associated with increased risk of Alzheimer's disease, APOA4 has been found to interact with amyloid-beta peptides, contributing to the formation of amyloid plaques in the brain. However, the specific role of APOA4 in the development or progression of neurological disorders is still under investigation.

Customer Reviews (5)

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Reviews
10/04/2022

    Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of theAPOA4 protein in various research studies.

    07/31/2021

      when employed in Western Blotting experiments, the APOA4 protein consistently generates sharp and well-defined protein bands, enabling precise visualization and analysis of protein expression.

      04/13/2021

        I highly recommend the use of theAPOA4 protein in various experimental applications.

        05/22/2020

          the APOA4 protein has been successfully utilized in protein electron microscopy structure analysis, providing valuable insights into molecular structures and interactions.

          11/19/2017

            Considering its outstanding performance across multiple assays, I confidently endorse the inclusion of the APOA4 protein in diverse research studies.

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