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APOBEC1

  • Official Full Name

    apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

  • Overview

    This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs.
  • Synonyms

    APOBEC1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; C-> U-editing enzyme APOBEC-1; APOBEC 1; BEDP; CDAR1; HEPR; apolipoprotein B mRNA-editing enzyme 1; apolipoprotein B mRNA editing enzyme complex-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APOBEC1-695H Recombinant Human APOBEC1 protein, GST-tagged Wheat Germ GST
Human APOBEC1-8786HCL Recombinant Human APOBEC1 293 Cell Lysate HEK293 N/A
Human APOBEC1-26872TH Recombinant Human APOBEC1 Wheat Germ N/A 100 amino acids
Mouse APOBEC1-1785M Recombinant Mouse APOBEC1 Protein Mammalian Cell His
Mouse APOBEC1-631M Recombinant Mouse APOBEC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse APOBEC1-631M-B Recombinant Mouse APOBEC1 Protein Pre-coupled Magnetic Beads HEK293
Rat APOBEC1-721R Recombinant Rat APOBEC1 Protein Mammalian Cell His
Rat APOBEC1-377R-B Recombinant Rat APOBEC1 Protein Pre-coupled Magnetic Beads HEK293
Rat APOBEC1-377R Recombinant Rat APOBEC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APOBEC1 Related Articles

APOBEC1 involved in several pathways and played different roles in them. We selected most pathways APOBEC1 participated on our site, such as Formation of the Editosome, Gene Expression, mRNA Editing, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOBEC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Formation of the EditosomeA1CF;APOBEC1
Gene ExpressionZFP143;ZNF180;ZNF471;AEBP2;POP1;IGF2BP3;POP4;FARS2;SNAPC1B
mRNA EditingAPOBEC1;A1CF;ADARB1;ADARB1A
mRNA Editing: C to U ConversionAPOBEC1;A1CF

APOBEC1 has several biochemical functions, for example, AU-rich element binding, RNA binding, cytidine deaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOBEC1 itself. We selected most functions APOBEC1 had, and list some proteins which have the same functions with APOBEC1. You can find most of the proteins on our site.

Function Related Protein
AU-rich element bindingZFP36L3;ZFP36;EXOSC7;TIAL1;ELAVL1;TIA1;HNRNPA0;NUDT21;EXOSC4
RNA bindingPABPN1L;CRNKL1;ZNF385D;AHCYL1;XPO1;SFPI1;QKIA;MPHOSPH6;RBM4B
cytidine deaminase activityAPOBEC3F;APOBEC2;APOBEC3H;APOBEC3G;CDA;WBP2NL;APOBEC1;AICDA
cytosine deaminase activity
protein bindingS100A10;BAP1;C19orf44;PUF60;SCO1;TFG;SSU72;PLG;SHANK3
zinc ion bindingZNF253;NAPEPLD;ANAPC11;NR3C1;MKRN1;TRIM35-27;ADH8B;ADAM23;SUPT4H1

APOBEC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOBEC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOBEC1.

Rathore, A; Carpenter, MA; et al. The Local Dinucleotide Preference of APOBEC3G Can Be Altered from 5 '-CC to 5 '-TC by a Single Amino Acid Substitution. JOURNAL OF MOLECULAR BIOLOGY 425:4442-4454(2013).
Burns, MB; Temiz, NA; et al. Evidence for APOBEC3B mutagenesis in multiple human cancers. NATURE GENETICS 45:977-+(2013).
  • Q&As
  • Reviews

Q&As (15)

Ask a question
Can APOBEC1 protein be targeted for cancer therapy? 02/16/2023

APOBEC1 protein has emerged as a potential target for cancer therapy due to its involvement in APOB mRNA editing and its role in tumor development. Inhibiting APOBEC1 activity could potentially restore the expression of full-length APOB protein in cancer cells, thereby inhibiting their growth and progression. However, further research is needed to develop specific and effective inhibitors of APOBEC1 for therapeutic purposes.

Is APOBEC1 protein expressed in tissues other than the intestine? 11/18/2022

While the highest expression of APOBEC1 protein is observed in the intestine, it can also be found in other tissues, albeit at lower levels. APOBEC1 expression has been detected in the liver, kidney, and colon, indicating potential roles in additional cellular processes beyond APOB mRNA editing. Research is ongoing to unravel the functions of APOBEC1 in these tissues.

Can APOBEC1 protein be a target for therapeutic interventions? 08/13/2022

Due to its involvement in lipid metabolism and its potential role in disease processes, APOBEC1 protein has been explored as a potential therapeutic target. Modulating the activity or expression of APOBEC1 could have implications for treating lipid disorders and other diseases associated with abnormal RNA editing processes. However, more research is needed to fully understand the potential therapeutic applications of targeting APOBEC1 protein.

Is APOBEC1 protein involved in any other biological processes? 05/31/2022

Besides its role in APOB mRNA editing, APOBEC1 protein has been implicated in other biological processes. It has been found to participate in RNA editing of other target RNA molecules and play a role in immune response modulation, viral restriction, and DNA mutagenesis.

Are there any diseases or conditions associated with dysregulation of APOBEC1 protein? 05/27/2022

Dysregulation of APOBEC1 protein has been implicated in several diseases and conditions. In addition to familial hypocholesterolemia type 2, alterations in the APOBEC1-mediated RNA editing process have been observed in certain liver cancers, where increased editing of APOB mRNA leads to reduced expression of full-length APOB protein. Furthermore, aberrant APOBEC1 activity has been linked to autoimmune diseases, such as systemic lupus erythematosus, where it contributes to the generation of autoantibodies.

Can APOBEC1 protein edit non-coding RNAs? 02/18/2022

Non-coding RNAs, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been found to be targets of APOBEC enzymes. While APOBEC1 primarily acts on coding mRNAs, there is evidence that it can also edit non-coding RNAs. For example, APOBEC1 was shown to edit lncRNA H19, leading to altered stability and function of the RNA molecule. The extent and functional implications of APOBEC1-mediated editing on non-coding RNAs are still being investigated.

Are there any drugs or compounds that can modulate APOBEC1 activity? 07/05/2020

Currently, there are no specific drugs or compounds that directly target APOBEC1 activity. However, several approaches have been explored to modulate APOBEC1 function indirectly. For example, small molecules targeting the APOBEC1 cofactor, ACF, have been investigated to disrupt the APOBEC1-ACF interaction and inhibit APOB mRNA editing. Additionally, targeting upstream signaling pathways or post-translational modifications that regulate APOBEC1 activity could be potential strategies to modulate its function.

Are there any genetic mutations associated with APOBEC1 protein? 06/07/2020

Yes, genetic mutations in the APOBEC1 gene can lead to altered function or expression of APOBEC1 protein. These mutations can affect the RNA-editing process, causing dysregulation of APOB mRNA editing and resulting in abnormal lipid metabolism and increased cardiovascular disease risk.

Can APOBEC1 protein edit other mRNAs besides APOB mRNA? 05/18/2020

APOBEC1 protein is primarily known for its role in editing APOB mRNA. However, recent studies have suggested that it may have the potential to edit other mRNA molecules as well. For example, APOBEC1 has been found to edit the mRNA encoding the HPV E6 oncoprotein, leading to reduced viral replication. Additionally, APOBEC1-mediated RNA editing has been implicated in the regulation of other genes involved in lipid metabolism and liver function. Further research is needed to fully understand the extent and significance of APOBEC1's editing activity on non-APOB mRNAs.

What are the consequences of APOBEC1 protein deficiency? 12/03/2019

APOBEC1 protein deficiency can result in the absence of apoB-48 production and an accumulation of full-length APOB mRNA. This condition is known as familial hypocholesterolemia type 2, characterized by reduced levels of low-density lipoprotein (LDL) cholesterol in the blood.

Can APOBEC1 protein cause DNA mutagenesis? 12/12/2018

Yes, APOBEC1 protein, like other APOBEC enzymes, has the potential to cause DNA mutagenesis. When aberrantly expressed or mislocalized in the nucleus, APOBEC1 can act on genomic DNA and induce C-to-U deamination. If not properly repaired, these mutations can lead to genetic alterations and contribute to the development of cancer or other genetic diseases.

How is the activity of APOBEC1 protein regulated? 06/25/2018

The activity of APOBEC1 protein is tightly regulated at multiple levels. It requires the presence of an RNA-binding protein called APOBEC1 complementation factor (ACF) to form a stable complex and efficiently edit APOB mRNA. Additionally, various post-translational modifications, including phosphorylation and acetylation, have been shown to modulate the catalytic activity and stability of APOBEC1 protein.

Can APOBEC1 protein be used as a diagnostic marker for any diseases? 01/14/2017

While APOBEC1 protein is not commonly used as a diagnostic marker, its dysregulation and altered activity have been associated with certain diseases. In the case of liver cancer, increased APOBEC1-mediated RNA editing of APOB mRNA has been observed as a molecular marker. Detecting alterations in APOBEC1 expression or activity may provide insights into disease progression or treatment response. However, further research is needed to establish APOBEC1 as a reliable diagnostic marker for clinical use.

Are there any naturally occurring inhibitors of APOBEC1 protein? 11/25/2016

Yes, several naturally occurring inhibitors of APOBEC1 protein have been identified. For example, RNA-binding protein HuR (Human antigen R) was found to interact with APOBEC1 and suppress its catalytic activity. Additionally, microRNA miR-27a can downregulate APOBEC1 expression and decrease its editing activity. These endogenous inhibitors may play a role in fine-tuning APOBEC1 function and maintaining cellular homeostasis.

How does APOBEC1 protein contribute to viral restriction? 06/27/2016

APOBEC1 and other members of the APOBEC family have demonstrated antiviral activity by inducing mutations in viral genomes. APOBEC1 can target the genomes of retroviruses, such as HIV-1, and introduce C-to-U editing, resulting in hypermutation and degradation of viral genetic material. This innate immune response helps limit viral replication and spread within the host.

Customer Reviews (4)

Write a review
Reviews
11/13/2021

    Its excellent performance in this application makes it a valuable asset in immunoassays and other biochemical studies.

    12/31/2017

      Its utilization in this technique has allowed for precise visualization and determination of protein structures with remarkable clarity and resolution.

      02/01/2017

        I am particularly impressed by APOBEC1 protein's versatility and reliability across different experimental techniques, showcasing its robustness and suitability for a wide range of research applications.

        04/28/2016

          APOBEC1 protein has proved to be an invaluable tool in protein electron microscopy structure analysis.

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