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APOL2

  • Official Full Name

    apolipoprotein L, 2

  • Overview

    This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    APOL2; apolipoprotein L, 2; apolipoprotein L2; APOL II; apolipoprotein L II; 9830006J20Rik; APOL-II; APOL3; Apol8; ApoLII; Apolipoprotein LII; ApolipoproteinL2; apolipoprotein L-II;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APOL2-9767H Recombinant Human APOL2, His-tagged E.coli His 1-337a.a.
Human APOL2-712H Recombinant Human APOL2 protein, GST-tagged Wheat Germ GST
Human APOL2-8777HCL Recombinant Human APOL2 293 Cell Lysate HEK293 N/A
Human APOL2-8778HCL Recombinant Human APOL2 293 Cell Lysate HEK293 N/A
Human APOL2-9732H Recombinant Human APOL2 Protein, His-tagged E. coli His
Human APOL2-3555H Recombinant Human APOL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human APOL2-0054H Recombinant Human APOL2 Protein (Gln186-Gln337), His-tagged E.coli His Gln186-Gln337
Human APOL2-2388H Recombinant Human APOL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human APOL2-1174HF Recombinant Full Length Human APOL2 Protein, GST-tagged In Vitro Cell Free System GST 337 amino acids
Cynomolgus Monkey APOL2-306C Recombinant Cynomolgus APOL2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey APOL2-56C Recombinant Cynomolgus Monkey APOL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey APOL2-56C-B Recombinant Cynomolgus Monkey APOL2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

APOL2 involved in several pathways and played different roles in them. We selected most pathways APOL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APOL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

APOL2 has several biochemical functions, for example, high-density lipoprotein particle binding, lipid binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOL2 itself. We selected most functions APOL2 had, and list some proteins which have the same functions with APOL2. You can find most of the proteins on our site.

Function Related Protein
high-density lipoprotein particle bindingAPOA1;GPIHBP1;APOL2;APOA2;APOA1A
lipid bindingAP2M1;APODB;OSBPL11;SH3GLB1;APOEB;ACOT12;STARD6;FABP1A;PTGS2
receptor bindingHFE;WNT4A;F2;GFRA1;FGF1A;WNT11R;AKAP9;CADM4;POU2F1

APOL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOL2.

FAM127A; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; MAST3; Tuba3a; UBL4A; MAPK3; BSG; Id2; MRPS9; NCBP1; TMEM63B; CERK; POLK

  • Q&As
  • Reviews

Q&As (17)

Ask a question
Is APOL2 involved in innate immunity? 03/28/2023

Yes, APOL2 plays a role in innate immunity. It is part of the APOL family of proteins, which are known to exhibit antimicrobial activity. APOL2 has been shown to exhibit potent activity against Trypanosoma brucei, a protozoan parasite that causes sleeping sickness in humans. This antimicrobial activity suggests that APOL2 contributes to the defense against certain pathogens.

What are the known interacting partners or binding partners of APOL2? 08/17/2022

APOL2 has been shown to interact with several proteins and molecules, suggesting its involvement in various cellular processes. Some of the known interacting partners of APOL2 include RAB7A, cathepsin D, and HSP90. These interactions suggest a role for APOL2 in endocytic pathways, lysosomal function, and protein folding. However, the full extent of APOL2's binding partners and their functional significance is still being explored.

What are the tissue-specific expression patterns of APOL2? 06/17/2022

APOL2 is expressed in various tissues, but its expression levels can vary depending on the tissue type. Studies have shown that APOL2 is expressed at higher levels in the liver, kidney, and spleen compared to other tissues. It is also found in other organs such as the heart, lung, and brain, albeit at lower levels. The tissue-specific expression patterns of APOL2 suggest that it may have distinct functions in different organs.

How does APOL2 contribute to cancer progression? 06/04/2021

APOL2 has been implicated in cancer progression through various mechanisms. It is known to promote apoptosis in certain cancer cells, thereby inhibiting tumor growth. However, some studies have also suggested that APOL2 may have oncogenic properties and contribute to cancer cell survival and invasion. The exact role of APOL2 in cancer progression is still unclear and may vary depending on the cancer type and context.

How is APOL2 related to cholesterol metabolism? 04/07/2021

APOL2 has been shown to bind to cholesterol and lipid molecules, suggesting a potential role in lipid metabolism. It may participate in the transport and regulation of cholesterol levels within cells.

Are there any known genetic mutations or variations in the APOL2 gene? 12/04/2020

Yes, there are known genetic variations in the APOL2 gene. Some studies have identified single nucleotide polymorphisms (SNPs) within the APOL2 gene that may be associated with various diseases, including cancer and cardiovascular disorders. However, further research is needed to confirm these associations and understand the functional consequences of these genetic variations.

Are there any known regulatory mechanisms that control APOL2 expression? 05/31/2020

The regulatory mechanisms controlling APOL2 expression are not fully understood. However, studies have identified some factors that can modulate APOL2 expression. For example, the transcription factor FoxO1 has been shown to regulate APOL2 expression, and its activation can upregulate APOL2 levels. Additionally, APOL2 expression has been found to be regulated by pro-inflammatory cytokines, such as interferon gamma (IFN-γ). Further research is needed to uncover the full range of regulatory mechanisms controlling APOL2 expression.

Can genetic testing be conducted for APOL2 variants? 08/30/2018

Currently, genetic testing specifically for APOL2 variants is not commonly available for diagnostic purposes or clinical use. However, as research on APOL2 and its potential implications progresses, there may be a growing interest in genetic testing for APOL2 variants in the future. It is advisable to consult with a healthcare professional or genetic counselor for more information about genetic testing options for APOL2 or similar genes.

Is APOL2 specific to humans, or is it present in other species too? 04/29/2018

APOL2 is evolutionarily conserved, meaning it is present in other species besides humans. It has been identified in various mammalian species, including chimpanzees, mice, and rats. However, the exact functions and roles of APOL2 in these other species may differ from humans.

Is there any ongoing research on APOL2? 12/08/2017

There is ongoing research on APOL2 to further investigate its functions and potential associations with diseases. Scientists are exploring its involvement in cancer progression, cellular processes related to autophagy and apoptosis, and its interactions with other proteins. Additional research is necessary to fully elucidate the role of APOL2 in human health and disease.

Are there any therapeutic implications or potential for targeting APOL2? 10/03/2017

The involvement of APOL2 in various diseases and cellular processes opens up potential therapeutic avenues. For example, considering its antimicrobial activity, targeting APOL2 or developing APOL2-derived peptides could potentially be used to treat infections caused by Trypanosoma brucei or other pathogens. Additionally, as APOL2 has been implicated in cancer progression, further studies may explore the therapeutic potential of targeting APOL2 for cancer treatment. However, more research is needed to fully understand the mechanisms of action of APOL2 and its therapeutic potential.

Are there any known genetic variations or mutations in the APOL2 gene? 06/17/2017

Yes, several genetic variations and mutations have been identified in the APOL2 gene. These genetic variants can result in different isoforms or alter the normal functioning of the APOL2 protein. For example, a genetic variant known as rs10772124 has been associated with increased risk of chronic kidney disease. Other studies have identified mutations in the APOL2 gene that are associated with increased susceptibility to certain parasitic infections, such as Trypanosoma cruzi, which causes Chagas disease. Further research is needed to fully understand the impact of these genetic variations and mutations on APOL2 function and disease susceptibility.

Can APOL2 be used as a diagnostic or prognostic marker for diseases? 05/26/2017

APOL2 has shown potential as a diagnostic or prognostic marker for certain diseases. For example, elevated APOL2 expression has been associated with poor prognosis in certain types of cancer, such as lung and gastric cancer. Additionally, APOL2 levels have been found to be altered in various diseases, including cardiovascular disorders, kidney disease, and diabetes. However, more research is needed to establish the clinical utility of APOL2 as a marker for disease diagnosis and prognosis.

How is APOL2 involved in apoptosis and autophagy? 11/10/2016

APOL2 has been suggested to modulate apoptosis and autophagy pathways. It has been shown to induce apoptosis in certain cancer cells and may play a role in regulating cellular survival and death. Additionally, APOL2 has been linked to autophagy-related processes, which involve the degradation and recycling of cellular components.

Are there any known diseases or conditions associated with APOL2? 03/19/2016

While APOL2 has been investigated in various diseases, its specific role remains unclear. Some studies have suggested a potential involvement of APOL2 in certain cancers, including breast and colorectal cancer. However, further research is needed to better understand the connection, and more studies are required to establish APOL2's role in diseases definitively.

Are there any known interactions between APOL2 and other proteins? 02/15/2016

Yes, there are known protein-protein interactions involving APOL2. For example, it has been shown to interact with the Bcl-2 family of proteins, which are involved in the regulation of apoptosis. Additionally, APOL2 may interact with various lipid-binding proteins and receptors. These interactions are important for understanding the functional mechanisms of APOL2 and its potential roles in cellular processes.

What are the potential therapeutic implications of APOL2? 02/13/2016

Due to its involvement in various cellular processes and potential links to diseases such as cancer, APOL2 may have therapeutic implications. Further research may uncover its role as a target for drug development or as a biomarker in disease diagnosis and prognosis. However, more studies are required to fully understand the therapeutic potential of APOL2 and its clinical applications.

Customer Reviews (4)

Write a review
Reviews
01/05/2021

    The manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.

    09/04/2020

      The manufacturer's team of experts possesses a deep understanding of the APOL2 protein and its associated protocols.

      07/09/2020

        This high-quality APOL2 protein provides researchers with confidence in obtaining accurate and reliable data during their investigations

        12/28/2018

          In conclusion, using APOL2 protein in trials offers distinct advantages for researchers studying cell cycle regulation.

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