APOL5
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Official Full Name
apolipoprotein L, 5
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Overview
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. -
Synonyms
APOL5; apolipoprotein L, 5; apolipoprotein L5; APOLV; apolipoprotein L-V; APOL-V;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | APOL5-715H | Recombinant Human APOL5 protein, GST-tagged | Wheat Germ | GST | ||
Human | APOL5-1330HF | Recombinant Full Length Human APOL5 Protein, GST-tagged | In Vitro Cell Free System | GST | 433 amino acids |
- APOL5 Related Articles
APOL5 involved in several pathways and played different roles in them. We selected most pathways APOL5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APOL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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APOL5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by APOL5 itself. We selected most functions APOL5 had, and list some proteins which have the same functions with APOL5. You can find most of the proteins on our site.
Function | Related Protein |
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APOL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOL5.
- Q&As
- Reviews
Q&As (14)
Ask a questionThe therapeutic potential of targeting APOL5 is currently unknown due to limited understanding of its exact function and regulatory mechanisms. Further studies are needed to fully characterize APOL5 and determine if modulating its activity would have any therapeutic benefits in specific diseases or pathological conditions.
Limited research suggests a potential association between APOL5 and kidney diseases. Some studies have found that certain genetic variants of APOL5 are associated with an increased risk of kidney diseases, including focal segmental glomerulosclerosis (FSGS) and HIV-associated nephropathy (HIVAN). However, further investigations are needed to understand the precise mechanisms and significance of this association.
Currently, the literature primarily focuses on the association of APOL5 with kidney diseases, particularly FSGS and HIVAN. However, there is emerging evidence suggesting potential links between APOL5 and other conditions. For example, some studies have found associations between APOL5 variants and prostate cancer, preeclampsia, and chronic kidney disease. Further research is needed to validate and understand these associations and to explore the role of APOL5 in other diseases or conditions.
There is currently no substantial evidence to suggest a direct involvement of APOL5 in neurodegenerative diseases or brain physiology. APOL5's functions and biological roles have primarily been investigated in the context of innate immunity and kidney diseases. Further studies are required to explore any potential links between APOL5 and the brain.
Currently, there are no established animal models specifically designed to study APOL5. However, researchers may use genetically modified mice or other animal models to investigate related processes or kidney diseases that have been linked to APOL5. Such models can provide insights into the physiological functions and potential roles of APOL5, although they do not precisely mimic the human genetic context.
Currently, there are no approved drugs or specific compounds targeting APOL5. However, the potential therapeutic applications of APOL5 modulation are being investigated, especially in the context of kidney diseases. Small molecule inhibitors, gene therapies, or other approaches that modulate APOL5 expression or activity may be explored in the future as potential therapeutic interventions.
Limited studies suggest a potential association between altered APOL5 levels and kidney diseases, as mentioned earlier. However, further investigations are required to determine if changes in APOL5 expression or activity contribute to the development or progression of other physiological or pathological conditions.
As of now, there are no known clinical trials specifically targeting APOL5. However, it's important to note that the understanding of APOL5 and its potential as a therapeutic target is an active area of research. Future studies may explore the therapeutic application of modulating APOL5 expression or activity in specific diseases, particularly those related to kidney pathologies.
APOL5 follows the general principles of genetic inheritance. It is inherited in an autosomal manner, meaning that both males and females are equally likely to inherit and transmit the gene. Each individual has two copies of the APOL5 gene, one inherited from each parent. Variants and mutations in APOL5 can be inherited in a dominant or recessive pattern, depending on the specific genetic alteration.
The protein interactions involving APOL5 are not well characterized. Limited information is available regarding potential interactions with other proteins. Further research is needed to uncover specific protein-protein interactions and their functional implications involving APOL5.
The potential use of APOL5 as a biomarker for specific diseases is still being explored. Currently, there is limited clinical evidence supporting APOL5 as a biomarker. However, some studies have suggested that APOL5 expression or genetic variants may be associated with certain kidney diseases, such as focal segmental glomerulosclerosis (FSGS) and HIV-associated nephropathy (HIVAN). Further research is needed to validate APOL5 as a reliable and specific biomarker for these or other diseases.
The exact cellular pathways linked to APOL5 are not fully understood. As a member of the APOL protein family, it is speculated that APOL5 may be involved in processes related to host-pathogen interactions, innate immunity, and cellular defense mechanisms. However, further research is required to comprehensively elucidate the specific pathways in which APOL5 participates.
Yes, certain mutations and genetic variants of the APOL5 gene have been identified. Some specific variants, such as rs758394972 and rs139858531, have been associated with an increased risk of kidney diseases, particularly focal segmental glomerulosclerosis (FSGS) and HIV-associated nephropathy (HIVAN). These variants have been found to be more prevalent in individuals of African ancestry.
The influence of natural compounds or lifestyle factors on APOL5 expression or activity has not been extensively studied. However, some research suggests that diet and metabolic factors, such as insulin resistance or obesity, may influence APOL5 gene expression. Additionally, certain environmental factors or exposures may impact APOL5 through epigenetic modifications. Further studies are needed to explore the potential modulation of APOL5 by natural compounds or lifestyle factors.
Customer Reviews (4)
Write a reviewA reliable manufacturer should be able to provide a consistently pure and high-quality APOL5 protein, ensuring that the samples are suitable for research purposes.
A manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.
This can help ensure compatibility between different components used in the trials and ease the overall experimental workflow.
A manufacturer that can deliver the protein promptly and reliably can save researchers time and allow them to proceed with their experiments without unnecessary delays.
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