ARAP3
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Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -
Overview
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. -
Synonyms
ARAP3;ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3;centaurin, delta 3 , CENTD3;arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3;DRAG1;FLJ21065;Ankyrin repeat and plekstrin homology domains containing protein 3;ARAP 3;ARF GAP;ARF-GAP RHO-GAP ankyrin repeat and plekstrin homology domains containing protein 3;Phosphoinositide binding protein;PtdIns 3 4 5 P3 binding protein;RHO GAP;cnt-d3;centaurin-delta-3;centaurin, delta 3;PtdIns(3,4,5)P3-binding protein;Arf and Rho GAP adapter protein 3;ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3;CENTD3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARAP3-9792H | Recombinant Human ARAP3, His-tagged | E.coli | Human | His | C-term-320a.a. | |
| ARAP3-2584H | Recombinant Human ARAP3 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| Arap3-317M | Recombinant Mouse Arap3 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
ARAP3 involved in several pathways and played different roles in them. We selected most pathways ARAP3 participated on our site, such as Rap signaling pathway,cAMP signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | SMURF2,CHMP2BB,SPG20,MHC1UXA2,CLTCB,GBF1,SNX3,WIPF2,MHC1UEA,PIP5K1C |
| Rap signaling pathway | VAV2,RHOA,PLCB4,F2R,INS,MLLT4,AKT1,PARD6A,MAP2K1,PRKD2 |
| cAMP signaling pathway | SLC9A1,GLP1R,OXTR,HTR6,PDE3A,GABBR2,ATP1B3,GNAI3,PPP1R12A,BRAF |
Protein Function
ARAP3 has several biochemical functions, for example, GTPase activator activity,NOT GTPase activator activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAP3 itself. We selected most functions ARAP3 had, and list some proteins which have the same functions with ARAP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | FOXP2,RREB1,PPP1R10,KDM6BB,FXC1,DPYDB,HPX,PPP4CA,RNF121,PPARAB |
| NOT GTPase activator activity | ELMOD3,DLC1 |
| protein binding | HSPA4,KIF5A,TSPAN12,TADA3,NPL,FOSL1,PSMC1,FAH,CUL9,HIST1H2AK |
| phosphatidylinositol-3,4-bisphosphate binding | AKT1,RAG2,COMMD1,MAPKAP1,FAM21C,RS1,TTPA,ANXA8,PLEKHA1,D6WSU116E |
| GTPase activator activity | SRGAP1,PLCB1,ARHGAP19,NIPAL1,ARHGAP44,TBC1D3,SMAP2,LLGL1,RIN1,RIC8 |
| phosphatidylinositol-3,4,5-trisphosphate binding | GAB2,CYTH3,MYO1G,PARD3,FAM21C,KIF16B,ARHGAP9,D6WSU116E,GBF1,OGT |
Interacting Protein
ARAP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAP3.
SH3KBP1;pi3p
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